Dr Abhilasha Karkey, DPhil.
Research Microbiologist – OUCRU Nepal.
Abhilasha Karkey is a medical microbiologist involved in clinical research at Oxford University Clinical Research Unit Nepal, Patan Hospital. She has a DPhil from the University of Oxford and an MSc in Medical Microbiology from the University of Liverpool. Abhilasha’s research focuses on enteric fever and antimicrobial resistance. Abhilasha is currently an OAK Scientific Leadership Fellow and her current work focus is on the development of antimicrobial resistance among the Gram-negative pathogens, especially Klebsiella pneumoniae. Her work looks at the risk factors for developing septicaemia among neonates within the intensive care units of Patan Hospital. Abhilasha has worked as a laboratory manager for Medecins Sans Frontieres (MSF) for over a decade, often in very difficult conflict areas. She is involved with teaching and curriculum setting for the Patan Academy of Health Sciences (PAHS), Patan Hospital. She is also a keen artist in her spare time.
Dr Karkey has published a number of articles in international journals. Highlight articles are listed below.
Pham Thanh D, Karkey A, Dongol S, Ho Thi N, Thompson CN, Rabaa MA, Arjyal A, Holt KE, Wong V, Tran Vu Thieu N, Voong Vinh P, Ha Thanh T, Pradhan A, Shrestha SK, Gajurel D, Pickard D, Parry CM, DOugan G, WOlbers M, Dolecek C, Thwaites GE, Basnyat B, Baker S. A novel ciprofloxacin-resistant subclade of H58 Salmonella Typhi is associated with fluoroquinolone treatment failure. Elife. 2016 Mar 11;5:e14003. doi: 10.7554/eLife.14003.
Karkey A, Jombart T, Walker AW, Thompson CN, Torres A, Dongol S, Tran Vu Thieu N, Pham Thanh D, Tran Thi Ngoc D, Voong Vinh P, Singer AC, Parkhill J, Thwaites G, Basnyat B, Ferguson N, Baker S. The ecological dynamics of fecal contamination and Salmonella Typhi and Salmonella Paratyphi A in municipal Kathmandu drinking water. PLoS Negl Trop Dis. 2016 Jan 6;10(1):e0004346. doi: 10.1371/journal.pntd.0004346.
Holmes AH, Moore LSP, Sundsfjord A, Steinbakk M, Regmi S, Karkey A, … Piddock LJV (2015). Understanding the mechanisms and drivers of antimicrobial resistance. The Lancet. http://doi.org/10.1016/S0140-6736(15)00473-0.
Dunstan SJ, Hue NT, Han B, Li Z, Tram TTB, Sim KS, … Khor CC (2014). Variation at HLA-DRB1 is associated with resistance to enteric fever. Nature Genetics, 46(12), 1333–6. http://doi.org/10.1038/ng.3143.
Karkey A, Thompson CN, Thieu NTV, Dongol S, Phuong TLT, Vinh Pv, et al. Differential epidemiology of Salmonella Typhi and Paratyphi A in Kathmandu, Nepal: A matched case control investigation in a highly endemic enteric fever setting. PLos Negl Trop Dis. 2013; 7(8): e2391. doi: 10.1371/journal.pntd.002391.
Baker S, Holt KE, Clements ACA, Karkey A, Arjyal A, Boni MF, et al. Combined high-resolution genotyping and geospatial analysis reveals modes of endemic urban typhoid fever transmission. Open Biology, 1. 2011. PMID: 22645647. doi: 10.1098/rsob.110008.
Karkey A, Arjyal A, Anders KL, Boni MF, Dongol S, Koirala S, et al. The Burden and Characteristics of Enteric Fever at a Healthcare Facility in a Densely Populated Area of Kathmandu. PLoS ONE. 2010; 5, e13988. PMID: 21085575. doi: 10.1371/journal.pone.0013988.
Nga T, Karkey A, Dongol S, Thuy H, Dunstan S, Holt K, et al. The sensitivity of real-time PCR amplification targeting invasive Salmonella serovars in biological specimens. BMC Infectious Diseases. 2010; 10, 125. PMID: 20492644. doi: 10.1186/1471-2334-10-125.
Karkey A, Aryjal A, Basnyat B, Baker S. Kathmandu, Nepal; Still an Enteric Fever Capital of the World. J Infect DevCtries. 2008; 2, 461 – 465. PMID: 19745524.