Oxford University Clinical Research Unit - Vietnam

Oxford University Clinical Research Unit - Vietnam

Oxford University Clinical Research Unit - Vietnam

Oxford University Clinical Research Unit - Vietnam

Publications 2000-2007

Pandit A, Arjyal A, Day JN, Paudyal B, Dangol S, Zimmerman MD, Yadav B, Stepniewska K, Campbell JI, Dolecek C, Farrar JJ, Basnyat B.An open randomized comparison of gatifloxacin versus cefixime for the treatment of uncomplicated enteric fever. PLoS ONE. 2007 Jun 27; 2( 6): e542.

Tanomsing N, Imwong M, Pukrittayakamee S, Chotivanich K, Looareesuwan S, Mayxay M, Dolecek C, Hien TT, do Rosario VE, Arez AP, Michon P, Snounou G, White NJ, Day NP.Genetic analysis of the dihydrofolate reductase-thymidylate synthase gene from geographically diverse isolates of Plasmodium malariae. Antimicrob Agents Chemother. 2007 Oct; 51( 10): 3523-30. Epub 2007 Aug 6. PMID: 17682097

Chau TT, Campbell JI, Galindo CM, Van Minh Hoang N, Diep TS, Nga TT, Van Vinh Chau N, Tuan PQ, Page AL, Ochiai RL, Schultsz C, Wain J, Bhutta ZA, Parry CM, Bhattacharya SK, Dutta S, Agtini M, Dong B, Honghui Y, Anh DD, Canh do G, Naheed A, Albert MJ, Phetsouvanh R, Newton PN, Basnyat B, Arjyal A, La TT, Rang NN, Phuong le T, Van Be Bay P, von Seidlein L, Dougan G, Clemens JD, Vinh H, Hien TT, Chinh NT, Acosta CJ, Farrar J, Dolecek C.Antimicrobial drug resistance of Salmonella enterica serovar typhi in asia and molecular mechanism of reduced susceptibility to the fluoroquinolones. Antimicrob Agents Chemother . 2007 Dec; 51( 12): 4315-23. Epub 2007 Oct 1.

Nguyen-Pouplin J, Tran H, Tran H, Phan TA, Dolecek C, Farrar J, Tran TH, Caron P, Bodo B, Grellier P. Antimalarial and cytotoxic activities of ethnopharmacologically selected medicinal plants from South Vietnam. J Ethnopharmacol. 2007 Feb 12;109(3):417-27. Epub 2006 Aug 15.

De Jong MD, Hayden FG. Spotlight on respiratory viruses: introduction . Antiviral Ther 2007; 12:579-80

M Crusat, M.D. de Jong. Neuraminidase inhibitors and their use in avian and pandemic influenza.Antiviral Ther 2007; 12 (4 Pt B):593-602

Joan L. Robinson, Bridget Wills, Scott B. Halstead, Joseph L. Mathew. Three commentaries on ‘Corticosteroids for treating dengue shock syndrome’, with introduction by EBCH editor. Evidence-based Child Health: a Cochrane Review Journal 2007; 2: 1080-1086.

Tang Chi Thuong, Nguyen Dac Tho, Ngo Thi Hoa, Nguyen Thi Minh Phuong, Le van Tuan, To Song Diep, Jodi Lindsay, Nguyen The Dung, Bach Van Cam, Le Quoc Thinh, Nguyen Thanh Hai, Le Dieu Linh, Jim Campbell, Nguyen Thi Kim Tien, Nguyen Van Vinh Chau, Joshua Cockfield, Le Truong Giang, Phan Van Nghiem, Le Hoang Son, Huynh Tan Son, Le Van Phung, Megan Counahan, Adwoa Bentsi-Enchill, Richard Brown James Simmerman, Nguyen Tran Chinh, Tran Tinh Hien, Jeremy Farrar, and Constance Schultsz. An outbreak of severe infections with community-acquired methicillin-resistant Staphylococcus aureus carrying the Panton-Valentine leukocidin following vaccination.PloSOne, 2007; 2(9): e822

Simmons CP, Chau TN, Thuy TT, Tuan NM, Hoang DM, Thien NT, Lien le B, Quy NT, Hieu NT, Hien TT, McElnea C, Young P, Whitehead S, Hung NT, Farrar J. Maternal antibody and viral factors in the pathogenesis of dengue virus in infants. J Infect Dis . 2007 Aug 1; 196( 3): 416-24. Epub 2007 Jun 19.

Christopher M Parry, Vo Anh Ho, Le Thi Phuong, Phan Van Be Bay, John Wain, Mai Ngoc Lanh, Le Thanh Tung, Nguyen Thi Hong Tham, Jeremy J Farrar A randomised controlled comparison of ofloxacin, azithromycin and an ofloxacin-azithromycin combination for treatment of multidrug-resistant and nalidixic acid resistant enteric fever. Antimicrobial Agents and Chemotherapy. 2007 Mar;51(3):819-25

Simmons CP, Popper S, Dolocek C, Chau TN, Griffiths M, Dung NT, Long TH, Hoang DM, Chau NV, Thao le TT, Hien TT, Relman DA, Farrar J. Patterns of host genome-wide gene transcript abundance in the peripheral blood of patients with acute dengue hemorrhagic fever. J Infect Dis. 2007 Apr 15; 195( 8): 1097-107.

Caws, M., D. Q. Tho, P. M. Duy, N. T. Lan, D. V. Hoa, M. E. Torok, T. T. Chau, N. V. Chau, N. T. Chinh, and J. Farrar. PCR-restriction fragment length polymorphism for rapid, low-cost identification of isoniazid-resistant Mycobacterium tuberculosis. J Clin Microbiol 2007,45:1789-93

Price RN, Dorsey G, Ashley EA, Barnes K, Baird K, d'Alessandro U, Guerin P, Laufer M, Naidoo I, Nosten F, Olliario P, Ringwald P, Sibley C, Stepniewska K, White NJ. World antimalarial resistance network1: clinical efficacy of antimalarial drugs.Malaria J 2007,6:119

Dong T, Moran E, Vinh Chau N, Simmons C, Luhn K, Peng Y, Wills B, Phuong Dung N, Thi Thu Thao L, Hien TT, McMichael A, Farrar J, Rowland-Jones S. High Pro-Inflammatory Cytokine Secretion and Loss of High Avidity Cross-ReactiveCytotoxic T-Cells during the Course of Secondary Dengue Virus Infection.PLoS ONE. 2007 Dec 5; 2( 12): e1192.

Caws, M., D. T. Ha, E. Torok, J. Campbell, D. A. Thu do, T. T. Chau, N. van Vinh Chau, N. T. Chinh, and J. Farrar. 2007. Evaluation of the MODS Culture Technique for the Diagnosis of Tuberculous Meningitis. PLoS ONE 2:e1173.

Nguyen Thi Hoang Mai, Tran Thi Hong Chau, Guy Thwaites, Ly Van Chuong, Dinh Xuan Sinh, Ho Dang Trung Nghia, Phung Quoc Tuan, Nguyen Duy Phong, Nguyen Hoan Phu,To Song Diep, Nguyen van Vinh Chau, Nguyen Minh Duong, James Campbell, Constance Schultsz, Chris Parry, M. Estee Torok, Nicholas White, Nguyen Tran Chinh, Tran Tinh Hien, Kasia Stepniewska, Jeremy J Farrar. Dexamethasone in Vietnamese adolescents and adults with bacterial meningitisNew England Journal of Medicine 2007, 357(24):24312440

ME Torok, Ho Dang Trung Nghia, Tran Thi Hong Chau, Nguyen Thi Hoang Mai, Guy Thwaites, Kasia Stepniewska, Jeremy Farrar. Validation of a diagnostic algorithm for adult tuberculous meningitis American Journal Tropical Medicine Hygiene 2007, 77(3):555-559

Anil Pandit, Amit Arjyal, Jeremy N Day, Buddhi Paudel, Sabina Dongol, Bharat Yadav, Kasia Stepniewska, James I Campbell,, Christiane Dolecek, Jeremy J. Farrar, Buddha Basnyat An open randomized comparison of gatifloxacin versus cefixime for the treatment of uncomplicated enteric fever. PLoS ONE. 2007 Jun 27;2:e542.

ME Torok. Neurological Infections; Clinical advances and emerging threats. Lancet Neurology 2007, 6:16-18

Caws, M., G. E. Thwaites, P. M. Duy, D. Q. Tho, N. T. Lan, D. V. Hoa, T. T. Chau, M. N. Huyen, P. T. Anh, N. V. Chau, T. N. Chinh, K. Stepniewska, and J. Farrar. 2007. Molecular analysis of Mycobacterium tuberculosis causing multidrug-resistant tuberculosis meningitis. Int J Tuberc Lung Dis 2007,11:202-8.

Farrar J, Focks D, Gubler D, Barrera R, Guzman MG, Simmons C, Kalayanarooj S, Lum L, McCall PJ, Lloyd L, Horstick O, Dayal-Drager R, Nathan MB, Kroeger A; WHO/TDR Dengue Scientific Working Group. Towards a global dengue research agenda. Trop Med Int Health. 2007 Jun; 12( 6): 695-9.

Thuong NT, Hawn TR, Thwaites GE, Chau TTH, Lan NTN, Quy HT, Hieu NT, Aderem A, Hien TT, Farrar JJ, Dunstan SJ. A polymorphism in human TLR2 is associated with increased susceptibility to Tuberculous meningitis. Genes Immun. 2007 Jul;8(5):422-8. Epub 2007 Jun 7.

Hawn TR, Misch EA, Dunstan SJ, Thwaites GE, Lan NTN, Quy HT, Chau TTH, Rodrigues S, Nachman A, Janer M, Hien TT, Farrar JJ, Aderem A. A common human TLR1 polymorphism regulates the innate immune response to lipopeptides. European Journal of Immunology, 2007 Aug;37(8):2280-9.

Dunstan SJ, Hue NT, Rockett K, Forton J, Morris AP, Diakite M, Lanh MN, Phuong LT, House D, Parry CM, Vinh H, Hieu NT, Dougan G, Hien TT, Kwiatowski D, Farrar JJ. A TNF region haplotype offers protection from Typhoid Fever in Vietnamese patients. Hum Genet. 2007 Aug;122(1):51-61. Epub 2007 May 15.

Holger J Schünemann, Suzanne R Hill, Meetali Kakad, Richard Bellamy, Timothy Uyeki, Frederick Hayden, Yazdan Yazdanpanah, John Beigel, Tawee Chotpitayasunondh, Chris Del Mar, Jeremy Farrar, Tran Tinh Hien, Bülent Özbay, Norio Sugaya, Andrew D Oxman. Transparent Development of the WHO Rapid Advice Guidelines. PLoS Medicine 2007 May;4(5):e119.

Simmons CP, Bernasconi NL, Mills K, Suguitan AL, Jr, Ward JM, Chau NVV, Hien TT, Sallusto F, Ha DQ, Farrar JJ, Jong MD, Lanzavecchia A, Subbarao K. Prophylactic and therapeutic efficacy of human monoclonal antibodies against H5N1 influenza. PLoS Medicine2007 May;4(5):e178.

Jansen GF, Krins A, Basnyat B, Odoom JA, Ince C. The role of the altitude level on cerebral autoregulation in man resident at high altitude. J Appl Physiol. 2007 Aug;103(2):518-23. Epub 2007 Apr 26.

Baird JK, Schwartz E, Hoffman SL. Prevention and treatment of vivax malaria. Curr Inf Dis Rep 2007, 9: 39-46

Baird JK. A rare glimpse at the efficacy of primaquine (Editorial Comment). Am J Trop Med Hyg. 2007 Feb;76(2):201-2.

Fryauff DJ, Owusu-Agyei S, Utz G, Baird JK, Koram KA, Binka F, Nkrumah F, Hoffman SL. Mefloquine treatment for uncomplicated falciparum malaria in young children 6-24 months of age in northern Ghana. Am J Trop Med Hyg. 2007 Feb;76(2):224-31.

Malacrida S, Katsuyama Y, Droma Y, Basnyat B, Angelini C, Ota M, Danieli GA. Association Between Human Polymorphic DNA Markers and Hypoxia Adaptation in Sherpa Detected by a Preliminary Genome Scan. Ann Hum Genet. 2007 Mar 15;

Lühn K, Simmons CP, Moran E, Dung NTP, Chau TNB, Thao LTT, Ngoc TV, Dung NM, Wills BA, Farrar JJ, McMichae AJ, Dong T, Rowland-Jones S. Increased Frequencies of CD4+CD25high Regulatory T cells in Acute Dengue Infection. J Exp Med. 2007 Apr 23;

Peiris JSM, De Jong MD, Guan Y. Avian Influenza virus (H5N1): a threat to human health. Clin Microbiol Rev 2007; 20: 243-267

Horby P. The global war on terrorism. Clin Infect Dis. 2007; 44(1):151. Letter.

Horby P. Determining risk factors for infection with influenza A(H5N1). Response to Lukkrafka et al. Emerg Infect Dis. 2007 July. Expedited on-line available at: http://www.cdc.gov/EID/content/13/6/955.htm

Khor CC, Chapman SJ, Vannberg FO, Dunne A, Murphy C, Ling EY, Frodsham AJ, Walley AJ, Kyrieleis O, Khan A, Aucan C, Segal S, Moore CE, Knox K, Campbell SJ, Lienhardt C, Scott A, Aaby P, Sow OY, Grignani RT, Sillah J, Sirugo G, Peshu N, Williams TN, Maitland K, Davies RJ, Kwiatkowski DP, Day NP, Yala D, Crook DW, Marsh K, Berkley JA, O'neill LA, Hill AV. Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis. Nature Genetics 2007; 39(4):523-528.

Lindegardh N, Davies GR, Hien TT, Farrar JJ, Singhasivanon P, Day NP, White NJ. Importance of collection tube during clinical studies of oseltamivir. Antimicrobial Agents and Chemotherapy. 2007 Feb 26;

Basnyat B. The treatment of enteric fever. J R Soc Med. 2007; 100(4):161-162.

Simmons CP, Popper S, Dolecek C, Chau TN, Griffiths M, Dung NT, Long TH, Hoang DM, Chau NV, Thao le TT, Hien TT, Relman DA, Farrar J. Patterns of host genome-wide gene transcript abundance in the peripheral blood of patients with acute dengue hemorrhagic fever. Journal of Infectious Diseases. 2007; 195(8):1097-1107

Medana IM, Day NP, Hien TT, Mai NT, Bethell D, Phu NH, Turner GD, Farrar J, White NJ, Esiri MM.Cerebral calpain in fatal falciparum malaria. Neuropathology and Applied Neurobiology 2007; 33(2):179-192

Schünemann HJ, Hill SR, Kakad M, Vist GE, Bellamy R, Stockman L, Wisløff TF, Mar CD, Hayden F, Uyeki TM, Farrar JJ, Yazdanpanah Y, Zucker H, Beigel J, Chotpitayasunondh T, Hien TT, Özbay B, Sugaya N, Oxman AD. WHO Rapid Advice Guidelines for pharmacological management of sporadic human infection with avian influenza A (H5N1) virus. Lancet Infectious Diseases 2007; 7(1):21-31.

Basnyat B. Reducing the incidence of high-altitude pulmonary edema. Ann Intern Med. 2007; 146(8):613-614.

Thwaites GE, Macmullen-Price J, Chau TTH, Mai PP, Dung NT, Simmons CP, White NJ, Hien TT, Summers D, Farrar JJ. Serial MRI to determine the effect of dexamethasone on the cerebral pathology of tuberculous meningitis: an observational study Lancet Neurology 2007; 6(3):230-236.