Prof Jeremy Day

Name

Prof Jeremy Day, MA MB BChir DTM&H PhD FRCP.

 

Position

Head, CNS and HIV Infections Research Group.
Wellcome Trust Intermediate Clinical Fellow.

 

About

Jeremy has been in Viet Nam since 2003 running and developing a clinical and basic science research programme in central nervous system infections, opportunistic infections and HIV. The work of the group encompasses bacterial meningitis, tuberculous meningitis, encephalitis, cryptococcal disease, penicilliosis and HIV as a primary CNS pathogen, and has contributed to international guidelines on disease management. Jeremy’s particular interest is cryptococcal disease in both HIV infected and uninfected patients. Research is based around large multicentre trials recruiting across Asia and Africa; in addition to improving treatment, his work focusses on better understanding the ecology of C. neoformans and the determinants of its pathogenicity.

 

Publications

Dr Day has published more than 40 articles in international journals. Key publications are listed below:

A Veringa, KCM van der Elst, JN Day, GE Thwaites, J-WCAlffenaar. Sertraline for HIV-associated cryptococcal meningitis. Lancet Infectious Diseases 2016 Oct;16(10):1111. doi: 10.1016/S1473-3099(16)30321-8. Epub 2016 Sep 19.

N D Bang, M Caws, TT Truc, TN Duong, NH Dung, DTM Ha, GE Thwaites, D Heemskerk, J Tarning, L Merson, PV Toi, J Farrar, M Wolbers, T Pouplin, J N Day. Clinical Presentations, Diagnosis, Mortality and Prognostic Markers of Tuberculous Meningitis in Vietnamese Children: A Prospective Descriptive Study. BMC Infectious Diseases 2016; 16: 573.

Beardsley J, Wolbers M, Day JN; CryptoDex Investigators. Dexamethasone in Cryptococcal Meningitis. N Engl J Med. 2016 Jul 14;375(2):189-90. DOI: 10.1056/NEJMc1605205

Thomas Pouplin, Nguyen Duc Bang, Pham Van Toi, Pham Nguyen Phuong, Nguyen Huy Dung, Tran Ngoc Duong, Maxine Caws, Guy E Thwaites, Joel Tarning, Jeremy N Day. Naïve-Pooled Pharmacokinetic Analysis of Pyrazinamide, Isoniazid And Rifampicin In Plasma And Cerebrospinal Fluid Of Vietnamese Children With Tuberculous Meningitis. BMC Infectious Diseases 2016; 16:144. DOI: 10.1186/s12879-016-1470-x

Justin Beardsley,  Marcel Wolbers, Freddie M Kibengo,  Abu-Baker M Ggayi,  Anatoli Kamali,  Ngo Thi Kim Cuc,   Tran Quang Binh, Nguyen Van Vinh Chau, Jeremy Farrar, Laura Merson,  Lan Phuong,  Guy Thwaites, Nguyen Van Kinh,   Pham Thanh Thuy,   Wirongrong Chierakul,  Suwatthiya Siriboon, Ekkachai Thiansukhon,  Satrirat Onsanit,  Watthanapong Supphamongkholchaikul,  Adrienne K Chan, Robert Heyderman, Mr Edson Mwinjiwa,  Joep J van Oosterhout,  Darma Imran, Hasan Basri, Mayfong Mayxay, David Dance,  Prasith Phimmasone,  Sayaphet Rattanavong,  David G. Lalloo, Jeremy N Day. A trial of adjunctive steroids in HIV associated cryptococcal meningitis. N Engl J Med 2016; 374:542-54

Dorothee Heemskerk, Nguyen Duc Bang, Nguyen Thi Hoang Mai, Tran Thi Hong Chau, Nguyen Hoan Phu, Pham Phu Loc, Nguyen Van Vinh Chau, Tran Tinh Hien, Nguyen Duc Dung, Nguyen Thi Ngoc Lan, Nguyen Huu Lan, Nguyen Ngoc Lan, Le Tan Phong, Nguyen Nang Vien, Nguyen Quang Hien, Nguyen Thi Bich Yen, Dang Thi Minh Ha, Jeremy Day, Maxine Caws, Laura Merson, Tran Thi Van Thinh, Marcel Wolbers, Guy E. Thwaites, Jeremy J. Farrar.: Intensified Antituberculosis Therapy in Adults with Tuberculous Meningitis. N Engl J Med 2016; 374:124-34. DOI: 10.1056/NEJMoa1507062

Thao V, Quang V, Day J, Chinh N, Shikuma C, Farrar J, Chau NVV, Thwaites G, Dunstan S, Le T. High prevalence of protease inhibitor resistance in patients failing second-line antiretroviral therapy in Vietnam. Journal Antimicrob. Chemotherapy. 2016 Mar; 71(3): 762–774. 10.1093/jac/dkv385

Thao VP, Quang VM, Wolbers M, Anh ND, Shikuma C, Farrar J, Dunstan S, Chau NV, Day J, Thwaites G, Le T. Second-Line HIV Therapy Outcomes and Determinants of Mortality at the Largest HIV Referral Center in Southern Vietnam. Medicine 2015 Oct;94(43):e1715. doi:  10.1097/MD.0000000000001715

Beardsley J, Denning DW, Chau NV, Chau NTB, Crump JA, Day JN: Estimating the burden of fungal disease in Vietnam. Mycoses, 2015, 58 (Suppl. S5), 101–106. DOI: 10.1111/myc.12382

Day JN and Wolbers MW: Limitation of the benefit of amphotericin-flucytosine combination therapy in patients with lower conscious level – an ecological fallacy? Open Forum Infectious Diseases 2015 2(2):1-2. doi:  10.1093/ofid/ofv069

Beardsley J, Thanh LT, Day J: A Model CNS Fungal Infection: Cryptococcal Meningitis. Curr Clin  Micro Rep. 2015 2:96-113. doi:10.1007/s40588-015-0016-0

Loyse A, Dromer F, Day J, Lortholary O,  Harrison TS. Flucytosine and cryptococcosis: time to urgently address the worldwide accessibility of a 50-year-old antifungal. J Antimicrob Chemother. 2013 Nov;68(11):2435-44. doi: 10.1093/jac/dkt221. Epub 2013 Jun 20. PMID: 23788479. doi: 10.1093/jac/dkt221

Day JN, Chau TT, Lalloo DG: Combination antifungal therapy for cryptococcal meningitis. N Engl J Med 2013, 368(26):2522-2523. doi: 10.1056/NEJMoa1110404.

Day JN, Chau TT, Wolbers M, Mai PP, Dung NT, Mai NH, et al. Combination antifungal therapy reduces mortality in severe cryptococcal meningitis. N Engl J Med 2013; 368:1291-1302. doi: 10.1056/NEJMoa1110404

Ho Dang Trung N, Le Thi Phuong T, Wolbers M, Nguyen Van Minh H, Nguyen Thanh V, Van MP, Thieu NTV, Le Van T, Song DT, Day JN et al: Aetiologies of central nervous system infection in Viet Nam: a prospective provincial hospital-based descriptive surveillance study. PLoS ONE 2012, 7(5):e37825. doi: 10.1371/journal.pone.0037825.

Henck DA, Shahar-Golan R, Devi KR, Zhan N, Fedorova N, Nierman WC, Hsueh P, Yuen K, Wertheim H, Day JN et al: Clonality despite sex, the evolution of sexual neighborhoods in the pathogenic fungus Penicillium marneffei. PLoS Pathog. 2012;8(10):e1002851. doi: 10.1371/journal.ppat.1002851. Epub 2012 Oct 4. doi: 10.1371/journal.ppat.1002851

Day JN, Hoang TN, Duong AV, Hong CTT, Diep, P. T., Campbell JI, et al.  Cryptococcal meningitis in HIV uninfected patients in Vietnam is due to a distinct AFLP-defined cluster of Cryptococcus neoformans var. grubii. J Clin Microbiol. 2011; 49(2), 658 – 664. doi: 10.1128/JCM.01985-10.

 

Dr Day’s Google Scholar Profile