NIH TBM Workshop: May 2017

Tuberculosis Meningitis: Advancing Immunopathogenesis, Diagnosis, and Treatment

Sponsored by

National Institute of Allergy and Infectious Diseases
Eunice Kennedy Shriver National Institute of Child Health and Human Development

May 22-23, 2017

5601 Fishers Lane, Room 1D13
Rockville, Maryland

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Day 1: May 22, 2017

Keynote Speaker: TBM Clinical Research Agenda
Guy Thwaites (University of Oxford)

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Keynote Speaker: Basic Science Review of Bacterial Meningitis
Nemani Prasadarao (Children’s Hospital Los Angeles)

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Session 1: Diagnostics and Biomarkers

Current and Future Ultra Diagnostics in TB Meningitis
David Boulware (University of Minnesota)

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Diagnostic and Prognostic Potential of Neuroimaging and Neurotissue Markers in Tuberculous Meningitis
Ursula Rohlwink (University of Cape Town)

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Potential Diagnostic Biomarkers
Keertan Dheda (University of Cape Town)

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Session 2, Part 1: Immunopathogenesis

Session Introduction
Reinout van Crevel (Radboud University Medical Center)

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Stroke in TB Meningitis: Path-Physiology, Clinical and Management Issues
Usha Kant Misra (Sanjay Gandhi Postgraduate Institute of Medical Sciences)

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Host Genotypes, Inflammatory Response and Outcome of TBM; Vietnam Cohort
Nguyen Thuy Thuong Thuong (Oxford University Clinical Research Unit, Ho Chi Minh City)

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Host Inflammatory Phenotype and Outcome TBM Indonesia
Arjan van Laarhoven (Radboud University Medical Center)

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Phosphodiesterase and DAMP Inhibitors as Adjunctive Agents
William Bishai (Johns Hopkins University)

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Session 2, Part 2: Modeling

Overview of Models of CNS TB and TB Meningitis
Sanjay K. Jain (Johns Hopkins University)

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A Zebrafish Model of TB Meningitis
Cressida Madigan (UCLA School of Medicine)

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CNS Barriers and Anti-microbial Immunity
Zsuzsanna Fabry (University of Wisconsin-Madison)

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Rabbit Model of TB Meningitis in Children
Liz Tucker (Johns Hopkins University)

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Insights from Animal Models of Chemotherapy for Cryptococcal Meningitis
John Perfect (Duke University)

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Molecular Imaging for Infections
Alvaro Ordoñez (Johns Hopkins University)

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Day 2: May 23, 2017
Session 2, Part 3: Host Directed Therapy

Overview of the HDT Landscape for Non-Meningeal TB
Robert Wallis (Aurum Institute)

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Insights into the Host Response and the Potential for HDT from Studies of HIV-TB Associated TBM IRIS
Robert Wilkinson (University of Cape Town, Imperial College London, Francis Crick
Institute)

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Use of Thalidomide in Childhood TB Meningitis
Johan Schoeman (Stellenbosch University)

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Glutathione as an Immunoadjuvant
Vishwanath Venketaraman (Western University of Health Sciences)

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Aspirin
Guy Thwaites (University of Oxford)

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Session 3: Optimized Tubercular Therapy

Drug Delivery to Meninges/CNS – PBPK, PK-PD
William Elmquist (University of Minnesota)

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Evaluation and Optimization of Existing and New TB drugs for TBM
Rob Aarnoutse (Radboud University Medical Center)

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Linezolid for TBM
Wenhong Zhang (Fudan University)

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Antimicrobial Management of Pediatric TBM
Kelly Dooley (Johns Hopkins University)

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Knowledge Gaps in HIV-TBM
Suzaan Marais (Inkosi Albert Luthuli Central Hospital)

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Neurosurgical and Supportive Management of TBM: Insights and Opportunities using Modern Tools
Tony Figaji (University of Cape Town)

Presentation is not available