Prof Tran Tinh Hien

Name

Tran Tinh Hien, MD, PhD, FRCP (Edin)

 

Position

Director of Clinical Research

 

About

Professor Tran Tinh Hien received his medical degree from the University of Medicine in Saigon, Vietnam in 1978, and his PhD from Oxford University Clinical Research Unit and the Open University UK in 2004. He was appointed Visiting Professor of Infectious Diseases at Oxford University, and has been a Fellow of the Royal College of Physicians (Edinburgh) since 2004. He has been working for the Hospital for Tropical Diseases in Ho Chi Minh City since 1978, first as Head of Intensive Care Unit, then in 1985 as Head of Malaria Ward, and in 1987 as Head of the Medical Service. He was appointed as its Vice Director in 1989. He is a member of several committees and advisory groups, including the Sub-Committee on the Management of Malaria, the National Malaria Control Programme for the MOH of Vietnam, the Management Committee on the National Project for the Control of Dengue Haemorrhagic Fever in Vietnam, and the Clinical Committee on the National Programme for the Control of Avian Influenza Virus Infection in Humans in Vietnam. In 2001, Dr Tran Tinh Hien was appointed member of the WHO Technical Advisory Group on Artemisinin Combined Therapy. He has worked as Principal Investigator for various projects on malaria and typhoid fever, funded by TDR/WHO, and the Wellcome Trust UK, has participated in 30 presentations, mainly on malaria, and is the author or co-author of more than 200 publications.

 

Current Employment

Director of Clinical Research Oxford University Clinical Research Unit Hospital for Tropical Diseases, Ho Chi Minh Vietnam (Centre of Tropical Medicine Oxford University, funded by the Wellcome Trust (2010 -2015)

 

Employment History

2010- Senior Consultant, Clinical Research Department of Health HCMC

1989 – 2009:  Vice Director, Hospital for Tropical Diseases

1987 – 1989: Head of Medical Service, Cho Quan Hospital

1985 – 1987: Head of Malaria Ward, Cho Quan Hospital

1978 – 1985: Head of Intensive Care Unit, Cho Quan Hosptial

 

Academic Activities

2008-2017: Member of the Independent Ethical Committee of The MoH Vietnam

2008-2017: Member of the Sanofi Dengue Vaccine IDMC

2006 – 2010: Member of Project Management Committee of National Project of Control of Dengue Hemorrhagic Fever, Vietnam

2009: Member of Advisory Board of Antibiotic Resistance in Vietnam

2008 – 2013: Member of the External Scientific Advisory Board (ESAC) of Medicines for Malaria Venture (MMV)

2005 – 2009: Member of Clinical Committee, National Programme of Control of Avian Influenza Virus Infection in Humans, Vietnam

2001- 2005: Member of WHO Technical Advisory Group on Artemisinin Combined Therapy

1993 – 1995: Head, Malaria Ward, Hospital for Tropical Diseases Vietnam

1991 – 1993: Head, Clinical Research Ward, Hospital for Tropical Disease, Vietnam

 

Qualifications

2011: Professor of Tropical Medicine Oxford University
Honorary Member of the American Society of Tropical Medicine and Hygiene

2010:  Mackay Medal by the Royal Society of Tropical Medicine and Hygiene
Visiting Professor of Tropical Medicine Oxford University UK

2004: Fellowship of the Royal College of Physicians UK

2004: PhD Oxford University of Clinical Research Unit, Vietnam and Open University UK

1978: Medical Degree University of Medicine Saigon Vietnam

 

Key Publications

Török ME, Aljayyoussi G, Waterhouse D, Chau T, Mai N, Phu NH, Hien TT, Hope W, Farrar JJ, Ward SA. Suboptimal Exposure to Anti-TB Drugs in a TBM/HIV+ Population is not Related to Anti-retroviral Therapy. Clin Pharmacol Ther. 2017 Feb 4. doi: 10.1002/cpt.646. [Epub ahead of print]

McBride A, Chau TT, Hong NT, Mai NT, Anh NT, Thanh TT, Van TT, Xuan LT, Sieu TP, Thai LH, Chuong LV, Sinh DX, Phong ND, Phu NH, Day J, Nghia HD, Hien TT, Chau NV, Thwaites G, Tan LV. Angiostrongylus cantonensis is an Important Cause of Eosinophilic Meningitis in Southern Vietnam. Clin Infect Dis. 2017 Feb 4. doi: 10.1093/cid/cix118. [Epub ahead of print] No abstract available.

Thanh NV, Thuy-Nhien N, Tuyen NT, Tong NT, Nha-Ca NT, Dong LT, Quang HH, Farrar J, Thwaites G, White NJ, Wolbers M, Hien TT.  Rapid decline in the susceptibility of Plasmodium falciparum to dihydroartemisinin-piperaquine in the south of Vietnam. Malar J. 2017 Jan 13;16(1):27. doi: 10.1186/s12936-017-1680-8.

Clarke GM, Rockett K, Kivinen K, Hubbart C, Jeffreys AE, Rowlands K, Jallow M, Conway DJ, Bojang KA, Pinder M, Usen S, Sisay-Joof F, Sirugo G, Toure O, Thera MA, Konate S, Sissoko S, Niangaly A, Poudiougou B, Mangano VD, Bougouma EC, Sirima SB, Modiano D, Amenga-Etego LN, Ghansah A, Koram KA, Wilson MD, Enimil A, Evans J, Amodu OK, Olaniyan S, Apinjoh T, Mugri R, Ndi A, Ndila CM, Uyoga S, Macharia A, Peshu N, Williams TN, Manjurano A, Sepúlveda N, Clark TG, Riley E, Drakeley C, Reyburn H, Nyirongo V, Kachala D, Molyneux M, Dunstan SJ, Phu NH, Quyen NN, Thai CQ, Hien TT, Manning L, Laman M, Siba P, Karunajeewa H, Allen S, Allen A, Davis TM, Michon P, Mueller I, Molloy SF, Campino S, Kerasidou A, Cornelius VJ, Hart L, Shah SS, Band G, Spencer CC, Agbenyega T, Achidi E, Doumbo OK, Farrar J, Marsh K, Taylor T, Kwiatkowski DP; MalariaGEN Consortium. Characterisation of the opposing effects of G6PD deficiency on cerebral malaria and severe malarial anaemia Elife. 2017 Jan 9;6. pii: e15085. doi: 10.7554/eLife.15085.

Nguyen TN, Thu PN, Hung NT, Son DH, Tien NT, Van Dung N, Quang HH, Seidlein LV, Cheah PY, Dondorp AM, Day NP, White NJ, Hien TT. Community perceptions of targeted anti-malarial mass drug administrations in two provinces in Vietnam: a quantitative survey. Malar J. 2017 Jan 6;16(1):17. doi: 10.1186/s12936-016-1662-2.

Jeeyapant A, Kingston HW, Plewes K, Maude RJ, Hanson J, Herdman MT, Leopold SJ, Ngernseng T, Charunwatthana P, Phu NH, Ghose A, Hasan MM, Fanello CI, Faiz MA, Hien TT, Day NP, White NJ, Dondorp AM. Defining Surrogate Endpoints for Clinical Trials in Severe Falciparum Malaria. PLoS One. 2017 Jan 4;12(1):e0169307. doi: 10.1371/journal.pone.0169307.

Hien TT, White NJ, Thuy-Nhien NT, Hoa NT, Thuan PD, Tarning J, Nosten F, Magnusson B, Jain JP, Hamed K. Estimation of the In Vivo MIC of Cipargamin in Uncomplicated Plasmodium falciparum Malaria. Antimicrob Agents Chemother. 2017 Jan 24;61(2). pii: e01940-16. doi: 10.1128/AAC.01940-16.

Grist EP, Flegg JA, Humphreys G, Mas IS, Anderson TJ, Ashley EA, Day NP, Dhorda M, Dondorp AM, Faiz MA, Gething PW, Hien TT, Hlaing TM, Imwong M, Kindermans JM, Maude RJ, Mayxay M, McDew-White M, Menard D, Nair S, Nosten F, Newton PN, Price RN, Pukrittayakamee S, Takala-Harrison S, Smithuis F, Nguyen NT, Tun KM, White NJ, Witkowski B, Woodrow CJ, Fairhurst RM, Sibley CH, Guerin PJ. Optimal health and disease management using spatial uncertainty: a geographic characterization of emergent artemisinin-resistant Plasmodium falciparum distributions in Southeast Asia. Int J Health Geogr. 2016 Oct 24;15(1):37.

Trung NT, Hien TT, Huyen TT, Quyen DT, Van Son T, Hoan PQ, Phuong NT, Lien TT, Binh MT, Van Tong H, Meyer CG, Velavan TP, Song le H. Enrichment of bacterial DNA for the diagnosis of blood stream infections. BMC Infect Dis. 2016 May 31;16:235. doi: 10.1186/s12879-016-1568-1.

Birgersson S, Van Toi P, Truong NT, Dung NT, Ashton M, Hien TT, Abelö A, Tarning J. Population pharmacokinetic properties of artemisinin in healthy male Vietnamese volunteers. Malar J. 2016 Feb 16;15:90. doi: 10.1186/s12936-016-1134-8.

Beardsley J, Wolbers M, Kibengo FM, Ggayi AB, Kamali A, Cuc NT, Binh TQ, Chau NV, Farrar J, Merson L, Phuong L, Thwaites G, Van Kinh N, Thuy PT, Chierakul W, Siriboon S, Thiansukhon E, Onsanit S, Supphamongkholchaikul W, Chan AK, Heyderman R, Mwinjiwa E, van Oosterhout JJ, Imran D, Basri H, Mayxay M, Dance D, Phimmasone P, Rattanavong S, Lalloo DG, Day JN; CryptoDex Investigators. Adjunctive Dexamethasone in HIV-Associated Cryptococcal Meningitis. N Engl J Med. 2016 Feb 11;374(6):542-54. doi: 10.1056/NEJMoa1509024.

Thuan PD, Ca NT, Van Toi P, Nhien NT, Thanh NV, Anh ND, Phu NH, Thai CQ, Thai le H, Hoa NT, Dong le T, Loi MA, Son do H, Khanh TT, Dolecek C, Nhan HT, Wolbers M, Thwaites G, Farrar J, White NJ, Hien TT. A Randomized Comparison of Chloroquine Versus Dihydroartemisinin-Piperaquine for the Treatment of Plasmodium vivax Infection in Vietnam. Am J Trop Med Hyg. 2016 Apr;94(4):879-85. doi: 10.4269/ajtmh.15-0740.

Heemskerk AD, Bang ND, Mai NT, Chau TT, Phu NH, Loc PP, Chau NV, Hien TT, Dung NH, Lan NT, Lan NH, Lan NN, Phong le T, Vien NN, Hien NQ, Yen NT, Ha DT, Day JN, Caws M, Merson L, Thinh TT, Wolbers M, Thwaites GE, Farrar JJ. Intensified Antituberculosis Therapy in Adults with Tuberculous Meningitis. N Engl J Med. 2016 Jan 14;374(2):124-34. doi: 10.1056/NEJMoa1507062.

Rosenberger KD, Lum L, Alexander N, Junghanss T, Wills B, Jaenisch T; DENCO Clinical Study Group. Vascular leakage in dengue–clinical spectrum and influence of parenteral fluid therapy. Trop Med Int Health. 2016 Mar;21(3):445-53. doi: 10.1111/tmi.12666.

Imwong M, Nguyen TN, Tripura R, Peto TJ, Lee SJ, Lwin KM, Suangkanarat P, Jeeyapant A, Vihokhern B, Wongsaen K, Van Hue D, Dong le T, Nguyen TU, Lubell Y, von Seidlein L, Dhorda M, Promnarate C, Snounou G, Malleret B, Rénia L, Keereecharoen L, Singhasivanon P, Sirithiranont P, Chalk J, Nguon C, Hien TT, Day N, White NJ, Dondorp A, Nosten F. The epidemiology of subclinical malaria infections in South-East Asia: findings from cross-sectional surveys in Thailand-Myanmar border areas, Cambodia, and Vietnam. Malar J. 2015 Sep 30;14:381. doi: 10.1186/s12936-015-0906-x.

Rabaa MA, Tue NT, Phuc TM, Carrique-Mas J, Saylors K, Cotten M, Bryant JE, Nghia HD, Cuong NV, Pham HA, Berto A, Phat VV, Dung TT, Bao LH, Hoa NT, Wertheim H, Nadjm B, Monagin C, van Doorn HR, Rahman M, Tra MP, Campbell JI, Boni MF, Tam PT, van der Hoek L, Simmonds P, Rambaut A, Toan TK, Van Vinh Chau N, Hien TT, Wolfe N, Farrar JJ, Thwaites G, Kellam P, Woolhouse ME, Baker S. The Vietnam Initiative on Zoonotic Infections (VIZIONS): A Strategic Approach to Studying Emerging Zoonotic Infectious Diseases. Ecohealth. 2015 Dec;12(4):726-35. doi: 10.1007/s10393-015-1061-0. Review.

WWARN Parasite Clearance Study Group., Abdulla S, Ashley EA, Bassat Q, Bethell D, Björkman A, Borrmann S, D’Alessandro U, Dahal P, Day NP, Diakite M, Djimde AA, Dondorp AM, Duong S, Edstein MD, Fairhurst RM, Faiz MA, Falade C, Flegg JA, Fogg C, Gonzalez R, Greenwood B, Guérin PJ, Guthmann JP, Hamed K, Hien TT, Htut Y, Juma E, Lim P, Mårtensson A, Mayxay M, Mokuolu OA, Moreira C, Newton P, Noedl H, Nosten F, Ogutu BR, Onyamboko MA, Owusu-Agyei S, Phyo AP, Premji Z, Price RN, Pukrittayakamee S, Ramharter M, Sagara I, Se Y, Suon S, Stepniewska K, Ward SA, White NJ, Winstanley PA. Baseline data of parasite clearance in patients with falciparum malaria treated with an artemisinin derivative: an individual patient data meta-analysis. Malar J. 2015 Sep 22;14:359. doi: 10.1186/s12936-015-0874-1.

Le Minh V, Thi Khanh Nhu N, Vinh Phat V, Thompson C, Huong Lan NP, Thieu Nga TV, Thanh Tam PT, Tuyen HT, Hoang Nhu TD, Van Hao N, Thi Loan H, Minh Yen L, Parry CM, Trung Nghia HD, Campbell JI, Hien TT, Thwaites L, Thwaites G, Van Vinh Chau N, Baker S. In vitro activity of colistin in antimicrobial combination against carbapenem-resistant Acinetobacter baumannii isolated from patients with ventilator-associated pneumonia in Vietnam. J Med Microbiol. 2015 Oct;64(10):1162-9. doi: 10.1099/jmm.0.000137.