Vu Thi Lan Huong, D.Phil.
Wellcome International Training Fellow
Evaluating the effectiveness of public health interventions is especially important in resource-limited settings to support the government in making informed decisions in the context of information scarcity and budget shortage. My research aims to generate evidence to support public health interventions in reducing the burden of illness and improving the quality of life of patients and their community. My current work involves community and hospital based studies on antimicrobial use and antimicrobial resistance (AMR), assessing factors that can be addressed to control the emergence and spread of resistance and preserve the efficacy of antibiotics, and identifying interventions that are responsive to the needs of the target populations in Vietnam. One major theme in my work focuses on antimicrobial stewardship, one of the key action areas in the global and national action plans to combat AMR. Our team established a multi-method participatory approach to antimicrobial stewardship: baseline qualitative assessments, reinforcing information sharing and discussions through stakeholder meetings and networks, collaborations with local and international partners in developing and evaluating multi-faceted interventions and performing cost-effectiveness analysis of these interventions to inform policy and actions.
Summary of research study under Wellcome International Training Fellowship
Uncontrolled use of antibiotic drugs to treat or prevent human infections with bacteria causes these bacteria to become resistant against antibiotics, particularly in countries with limited resources. Actions are required to reduce and restrict (unnecessary) antibiotic use. This study will assess the impact of interventions that aim to improve antibiotic use in hospitals to determine if these are good value for money. I will collect data on the amount of antibiotic use, the number of patients who died, bacteria resistant to important antibiotics, and costs of these interventions in three hospitals in Vietnam. In addition, I will use the existing data from the national resistance surveillance programme to understand the patterns of antibiotic use and resistance and how these data can help to plan interventions in hospitals. The findings are useful to support governments to make decisions on how best to address the antibiotic resistance problem in resource-limited countries.
Huong Vu has published 14 articles in international journals since her research career started in 2010 on various public health issues.
Google Scholar: https://scholar.google.com/citations?user=mcvBFlgAAAAJ&hl=vi
5 key recent research articles:
- Hanh HN; Phuc HD; Huong VTL; Toan TK; Do TT; Chuc NTK; van Doorn HR; Nadjm B; Kinsman J; Wertheim H. “I can make more from selling medicine when breaking the rules” – Understanding the antibiotic supply network in a rural community in Viet Nam. BMC Public Health. 2019 (paper accepted).
- Huong VTL, Turner CH, Kinh NV, Thai PQ, Hoa NT, Horby P, van Doorn HR, Wertheim HFL. Burden of disease and economic impact of human Streptococcus suis infection in Viet Nam. Transactions of the Royal Society of Tropical Medicine and Hygiene. 2019; 113 (6); 341–350
- Bonell A, Azarrafiy R, Huong VTL, Viet TL, Phu VD, Dat VQ, Wertheim H, van Doorn HR, Lewycka S, Nadjm B. A systematic review and meta-analysis of ventilator associated pneumonia in adults in Asia; an analysis of national income level on incidence and etiology. Clinical Infectious Diseases. 2018. https://doi.org/10.1093/cid/ciy543.
- Dat VQ, Huong VTL, Turner HC, Thwaites L, van Doorn HR, Nadjm B. Excess direct hospital cost of treating adult patients with ventilator associated respiratory infection (VARI) in Vietnam. PloS ONE. 2018, 13(10): e0206760. https://doi.org/10.1371/journal.pone.0206760.
- Huong VTL, Long HB, Kinh NV, Ngan TTD, Dung VTV, Nadjm B, van Doorn HR, Hoa NT, Horby P, Wertheim HFL. Long-term outcomes of patients with Streptococcus suis infection in Vietnam: a case-control study. Journal of Infection. 2017. pii: S0163-4453(17)30311-0. doi: 10.1016/j.jinf.2017.09.019. PMID: 28970042.