{"id":2557,"date":"2014-08-01T15:16:48","date_gmt":"2014-08-01T08:16:48","guid":{"rendered":"https:\/\/www.oucru.org\/?p=2557"},"modified":"2014-08-01T15:31:35","modified_gmt":"2014-08-01T08:31:35","slug":"the-mechanism-of-antibody-activity-during-salmonella-typhi-and-salmonella-paratyphi-a-infections","status":"publish","type":"post","link":"https:\/\/www.oucru.org\/id\/the-mechanism-of-antibody-activity-during-salmonella-typhi-and-salmonella-paratyphi-a-infections\/","title":{"rendered":"The mechanism of antibody activity during Salmonella Typhi and Salmonella Paratyphi A infections"},"content":{"rendered":"

Oxford University Clinical Research Unit Vietnam PhD Programme 2014-15<\/span><\/strong><\/p>\n

<\/strong>Project 5: <\/strong><\/p>\n

The mechanism of antibody activity during Salmonella Typhi and Salmonella Paratyphi A infections<\/strong><\/p>\n

<\/strong>Required person<\/strong>: Basic laboratory scientist\/bioinformatician\/immunologist<\/p>\n

Type of project<\/strong>: Bacteriology\/immunology<\/p>\n

Potential start date: <\/strong>First quarter 2015<\/p>\n

Duration<\/strong>: Four years<\/p>\n

Techniques<\/strong>: Immunology, bacteriology, diagnostics, molecular biology<\/p>\n

Location<\/strong>: Ho Chi Minh City, Vietnam, The Wellcome Trust Sanger Institute, Cambridge UK<\/p>\n

Group:<\/strong> Enteric Infections<\/p>\n

Supervisor: <\/strong>Guy Thwaites, Gordon Dougan, Stephen Baker<\/p>\n

Current status<\/strong>: Ethical approval obtained, funded, publication<\/p>\n

Collaborations<\/strong>: Oxford University ? UK, Oxford University Clinical Research Unit ? Nepal, The Wellcome Trust Sanger Institute, Cambridge UK<\/p>\n

Brief outline<\/strong><\/p>\n

Salmonella<\/em> Paratyphi A is a largely understudied cause of enteric fever, and in some locations is replacing Salmonella<\/em> Typhi as the major cause of bacteremia. Currently there are limited data on clinical response to therapy, phylogeny or specific immunological responses to Salmonella<\/em> Paratyphi A and Salmonella<\/em> Typhi during and after acute infection. However, we know that antibody responses to classical invasive Salmonella<\/em> antigens (O-antigen Vi) are induced during acute enteric fever and such responses likely contribute to immunity (as indicated by data from both immunization and natural history of disease). Consequently, we hypothesize that additional antigen specific antibody responses, which are induced during enteric fever, are important for homotypic and heterotypic (Typhi and Paratyphi A) immunity and for stimulating bacteriocidal killing.<\/p>\n

Potential thesis areas<\/strong><\/p>\n