{"id":46369,"date":"2025-04-16T09:46:53","date_gmt":"2025-04-16T02:46:53","guid":{"rendered":"https:\/\/www.oucru.org\/?p=46369"},"modified":"2025-04-18T16:11:26","modified_gmt":"2025-04-18T09:11:26","slug":"dr-sulochana-manandhar-on-tackling-newborn-infection-risks-in-nepal","status":"publish","type":"post","link":"https:\/\/www.oucru.org\/id\/dr-sulochana-manandhar-on-tackling-newborn-infection-risks-in-nepal\/","title":{"rendered":"Dr Sulochana Manandhar: Tackling newborn infection risks in Nepal\u00a0"},"content":{"rendered":"

Navigating Barriers as a Young Researcher in Nepal<\/h3>\n

\u201cAs an early-career researcher from the Global South, securing research funding has been a significant challenge,\u201d says Dr Sulochana Manandhar<\/a> of OUCRU Nepal. \u201cA limited scientific network and lack of mentorship made it harder to refine my ideas and design studies that could move from concept to reality.\u201d<\/p>\n

Trained in microbiology, Dr Manandhar\u2019s early research centred on bacterial neonatal infections, including that of Group B Streptococcus <\/em>(GBS) and associated antimicrobial resistance (AMR). While technically proficient, she struggled to translate her ideas into fundable, feasible research. \u201cI often focused heavily on the scientific details, without fully understanding how to connect my work to broader health systems or real-world priorities,\u201d she reflects.<\/p>\n

\"\"<\/a>
Dr Sulochana Manandhar, microbiologist at OUCRU Nepal and member of the first MODRA cohort. (Photo: OUCRU, 2024)<\/em>\u00a0<\/figcaption><\/figure>\n

That began to change in 2024, when Dr Manandhar joined the MORU\u2013OUCRU Discovery Research Academy (MODRA)<\/a>, a transformative step that helped her move beyond the lab bench and into clinical research leadership. \u201cMODRA introduced me to the logical framework tool for proposal writing,\u201d Dr Manandhar explains. \u201cIt helped me define clear research outputs and outcomes, and to align my proposal with real-world needs and funder expectations.\u201d<\/p>\n

Through structured training and tailored mentorship, she developed a system-aware approach to research. \u201cMy mentors taught me how to think beyond the science. They gave me crucial insights into how funding bodies assess proposals, especially how they value real-world impact and social relevance alongside scientific findings.\u201d<\/p>\n

Leading Her First Hospital-Based Study<\/h3>\n

With support from MODRA\u2019s seed award, Dr Manandhar is now leading her first clinical study, investigating the prevalence of GBS among pregnant women and newborns in Nepal. Although GBS is known to cause neonatal infections globally, it remains underreported in Nepal.<\/p>\n

\u201cConducting a hospital-based study has been a steep learning curve,\u201d she says. \u201cFrom navigating ethics approval to coordinating with hospital staff and managing sample logistics, MODRA gave me the leadership and project management skills I needed.\u201d<\/p>\n

\"\"<\/a>
1-on-1 consultation with Mr Dave Gandy (Grants & Contracts Manager, MORU) on grant writing and budgeting during a MODRA training in Bangkok. (Photo: OUCRU, 2024)<\/figcaption><\/figure>\n

Her study is based at Siddhi Memorial Women and Children Hospital<\/a> in Bhaktapur, Nepal, a site selected for its maternity services and positive research culture. \u201cCollaborating with a hospital that values research made all the difference. They saw how the findings could inform their own clinical guidelines.\u201d<\/p>\n

Alongside her local research, Dr Manandhar also built new international collaborations. With support from her MODRA mentor, Dr Claire Chewapreecha<\/a> of MORU<\/a>, she initiated a partnership with the the JUNO Project<\/a> at the Wellcome Sanger Institute<\/a>. Recognising the scientific value of her study, JUNO provided high-quality reagents essential for isolating GBS and supported whole-genome sequencing of the samples.<\/p>\n

These data, not previously available in Nepal, will help researchers understand how local GBS strains relate to those circulating globally, which will inform the development of more effective vaccines.<\/p>\n

From Pilot Data to Health System Impact<\/h3>\n

Dr Manandhar\u2019s study is designed as a proof-of-concept, to generate the first set of local data that could shape maternal-neonatal health policy in Nepal.<\/p>\n

\u201cWe\u2019ve engaged the hospital leadership from the start,\u201d she explains. \u201cIf our findings confirm that GBS is an under-diagnosed risk, it could support the case for routine antenatal screening, something already standard in many high-income countries.\u201d<\/p>\n

Looking ahead, she plans to scale the research to multiple hospitals across Nepal, and potentially other countries in the region. \u201cThere\u2019s so much more to explore, host factors, pathogen genomic differences, host-pathogen interactions resulting into observed stark regional disparities. MODRA has laid the foundation for all of it.\u201d<\/p>\n

\"\"<\/a>
At the OUCRU Nepal’s latest microbiology laboratory, inaugurated in 2024. (Photo: OUCRU, 2024)<\/em>\u00a0<\/figcaption><\/figure>\n

Now mentoring junior colleagues at OUCRU Nepal, Dr Manandhar encourages early-career researchers to invest in collaborative networks from the start. \u201cStrong partnerships shape stronger science. They bring in fresh perspectives, sharpen ideas, and offer practical support you simply can\u2019t get alone.\u201d<\/p>\n

Her advice to future applicants? \u201cDon\u2019t wait for the \u2018perfect\u2019 project. Be open to growth and surround yourself with people who push your thinking. MODRA helped me shift from working in isolation to leading with clarity and purpose.\u201d<\/p>\n

About MODRA<\/h3>\n

The MORU\u2013OUCRU Discovery Research Academy (MODRA)<\/a> is a fully funded 18-month programme designed to empower early-career postdocs scientists in Asia with the skills, mentorship, and funding needed to become independent researchers.<\/p>\n

Participants receive:<\/p>\n

\u2023 Hands-on workshops on grant writing, budgeting, research design and project management.
\n\u2023 Ongoing mentorship from regional and global research leaders.
\n\u2023 Seed funding of up to $30,000 to launch preliminary research.<\/p>\n

This programme is a joint initiative by the Oxford University Clinical Research Unit (OUCRU)<\/a> and the Mahidol Oxford Tropical Medicine Research Unit (MORU)<\/a>, both leading centres in global health research. MODRA is funded by Wellcome Trust<\/a> and affiliated with the Centre for Tropical Medicine and Global Health <\/a>at the University of Oxford,<\/a> ensuring world-class standards in training and mentorship.<\/p>\n

If you’re ready to step into leadership and drive meaningful impact in global health, apply today<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"

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