Funder: OUCRU (Wellcome funding)
Principal Investigator: Maia Rabaa
Location of activity: Vietnam
- To define the frequency and characteristics of asymptomatic carriage of SARS-CoV-2 in health care workers caring for COVID-19 patients.
- To define the frequency of COVID-19 occurring in health care workers caring for COVID-19 patients.
- To define the duration of detectable SARS-CoV-2 in health care workers prior to developing symptoms.
- To determine whether transmission of SARS-CoV-2 occurs from health care workers (asymptomatic and prodromal) to community contacts.
- To demonstrate the utility of filter paper collection of saliva as a surveillance tool for SARS-CoV-2 infection.
- To investigate the molecular epidemiology, intrahost diversity and evolution of SARS-CoV-2 in asymptomatic and symptomatic SARS-CoV-2 infections in health care workers.
Understanding the risk of carriage and transmission to and by health care workers will enable the design of interventions to reduce this risk. Development of a robust cold chain-independent sampling modality will enable enhanced population surveillance, diagnosis and follow-up.
- Early identification and understanding of the incidence of symptomatic and asymptomatic infection in health care workers.
- Assessment of the risk of transmission to the community by asymptomatic health care workers.
- Assessment of filter paper-based saliva sample collection for the diagnosis and sequence characterisation of SARS-CoV-2.
- Sequence & epidemiological analysis of transmission from infected patients to HCWs (coupling with data collected under other studies).
Outputs to date
- The first 100 days of SARS-Cov-2 control in Vietnam
- RT-PCR detection of SARS-CoV-2 from dried saliva samples collected on FTA filter paper (in progress)