The clinical features, epidemiology, immunology and host genetics associated with SARS-CoV-2 infection in children and adults in Ho Chi Minh City, Viet Nam

OUCRU Principal Investigator: Le Van Tan
Partner Principal Investigator: Dr Nguyen Van Vinh Chau (Hospital for Tropical Diseases), Dr Nguyen Thanh Hung (Children’s Hospital 1, Ho Chi Minh City, Vietnam), Dr Nguyen Tran Nam (City Children’s Hospital, Ho Chi Minh City, Vietnam)
Location of activity: Ho Chi Minh City, Viet Nam

Background
The on-going nation-wide outbreak caused by the Delta variant in a relatively naïve population in Vietnam necessitates a multidisciplinary research approach to better understand the clinical futures, virology, pathophysiology and associated host genetic factors of the infections, especially determinants of severe diseases. These data are critical to informing the development of appropriate intervention strategies, thereby improving clinical outcomes and mitigating the impacts of the COVID-19 pandemic.

Aims
1. To describe the clinical features and associated laboratory findings in children and adults with SARS-CoV-2 infection
2. To understand the circulation and evolution of SARS-CoV-2 in Viet Nam
3. To describe and compare SARS-CoV-2 viral loads in children and adults
4. To gain insights into the immune responses in children and adults infected with SARS-CoV-2 infections
5. To identify potential factors (including host-genetic markers) that are associated with poor clinical outcome of SARS-CoV-2 infection.

Impact
The study results would inform the global research agenda on clinical management and the development of intervention strategies aiming at reducing the burden posed by COVID-19 and SARS-CoV-2 infections.

Outputs to date:
Ton That Thanh, Nguyen Thi Thanh Nhan, Nguyen To Anh et al. SARS-CoV-2 RNA loads in Vietnamese children. Journal of Infection [Internet] 2022. Available from: https://doi.org/10.1016/j.jinf.2022.01.010