{"id":36663,"date":"2024-02-08T17:21:10","date_gmt":"2024-02-08T10:21:10","guid":{"rendered":"https:\/\/www.oucru.org\/nghien-cuu-cua-oucru-phat-trien-cong-cu-chan-doan-moi-cho-lao-mang-nao-o-nguoi-lon\/"},"modified":"2024-02-08T19:33:50","modified_gmt":"2024-02-08T12:33:50","slug":"chan-doan-lao-mang-nao","status":"publish","type":"post","link":"https:\/\/www.oucru.org\/vi\/chan-doan-lao-mang-nao\/","title":{"rendered":"Nghi\u00ean c\u1ee9u c\u1ee7a OUCRU ph\u00e1t tri\u1ec3n c\u00f4ng c\u1ee5 ch\u1ea9n \u0111o\u00e1n m\u1edbi cho lao m\u00e0ng n\u00e3o \u1edf ng\u01b0\u1eddi l\u1edbn"},"content":{"rendered":"\n

B\u1ec7nh lao ph\u1ed5i do vi khu\u1ea9n Mycobacterium<\/em> tuberculosis<\/em><\/a> (Mtb<\/em>) x\u00e2m nh\u1eadp c\u1ea5u tr\u00fac m\u00e0ng n\u00e3o g\u00e2y ra, l\u00e0 d\u1ea1ng bi\u1ebfn ch\u1ee9ng nguy hi\u1ec3m nh\u1ea5t c\u1ee7a b\u1ec7nh lao. Lao m\u00e0ng n\u00e3o t\u00e1c \u0111\u1ed9ng \u0111\u1ebfn c\u00e1c l\u1edbp m\u00e0ng b\u1ea3o v\u1ec7 n\u00e3o v\u00e0 t\u1ee7y s\u1ed1ng. N\u1ebfu kh\u00f4ng \u0111\u01b0\u1ee3c can thi\u1ec7p k\u1ecbp th\u1eddi, b\u1ec7nh th\u01b0\u1eddng d\u1eabn \u0111\u1ebfn c\u00e1i ch\u1ebft. <\/p>\n\n\n\n

Ch\u1ea9n \u0111o\u00e1n lao m\u00e0ng n\u00e3o s\u1edbm v\u00e0 ch\u00ednh x\u00e1c l\u00e0 c\u1ef1c k\u1ef3 c\u1ea5p thi\u1ebft. Tuy nhi\u00ean, qu\u00e1 tr\u00ecnh n\u00e0y \u0111\u1ea7y r\u1eaby kh\u00f3 kh\u0103n do thi\u1ebfu ph\u01b0\u01a1ng ph\u00e1p x\u00e9t nghi\u1ec7m chu\u1ea9n m\u1ef1c, nhanh ch\u00f3ng v\u00e0 ch\u00ednh x\u00e1c. Tr\u01b0\u1edbc \u0111\u00e2y, vi\u1ec7c ch\u1ea9n \u0111o\u00e1n lao m\u00e0ng n\u00e3o ph\u1ee5 thu\u1ed9c nhi\u1ec1u v\u00e0o kinh nghi\u1ec7m v\u00e0 nh\u1eadn \u0111\u1ecbnh ch\u1ee7 quan c\u1ee7a b\u00e1c s\u0129. Nghi\u00ean c\u1ee9u m\u1edbi c\u1ee7a OUCRU<\/a> \u0111\u00e3 \u0111\u01b0a ra ph\u01b0\u01a1ng ph\u00e1p ch\u1ea9n \u0111o\u00e1n c\u1ea3i ti\u1ebfn gi\u00fap b\u00e1c s\u0129 c\u00f3 th\u1ec3 ph\u00e1t hi\u1ec7n lao m\u00e0ng n\u00e3o s\u1edbm, c\u00f3 th\u1ec3 ngay t\u1eeb khi b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c nh\u1eadp vi\u1ec7n. <\/p>\n\n\n\n

Ch\u1ea9n \u0111o\u00e1n lao m\u00e0ng n\u00e3o <\/h2>\n\n\n\n

Nghi\u00ean c\u1ee9u \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n b\u1edfi Ti\u1ebfn s\u0129 \u0110\u1ed3ng H\u1eefu Kh\u00e1nh Tr\u00ecnh<\/a>, Ph\u00f3 Gi\u00e1o s\u01b0 Ronald Geskus<\/a> v\u00e0 c\u1ed9ng s\u1ef1, \u0111\u00e3 ph\u00e2n t\u00edch d\u1eef li\u1ec7u t\u1eeb 659 b\u1ec7nh nh\u00e2n t\u1eeb 16 tu\u1ed5i tr\u1edf l\u00ean b\u1ecb nghi ng\u1edd nhi\u1ec5m tr\u00f9ng n\u00e3o nh\u1eadp vi\u1ec7n t\u1ea1i B\u1ec7nh vi\u1ec7nB\u1ec7nh Nhi\u1ec7t \u0111\u1edbi Th\u00e0nh ph\u1ed1 H\u1ed3 Ch\u00ed Minh.<\/a> Nh\u00f3m nghi\u00ean c\u1ee9u \u0111\u00e3 x\u00e2y d\u1ef1ng c\u00f4ng c\u1ee5 d\u1ef1a tr\u00ean m\u00f4 h\u00ecnh l\u1edbp ti\u1ec1m \u1ea9n, s\u1eed d\u1ee5ng c\u00e1c d\u1eef li\u1ec7u l\u00e2m s\u00e0ng, sinh h\u00f3a v\u00e0 huy\u1ebft h\u1ecdc ban \u0111\u1ea7u \u0111\u1ec3 \u0111\u00e1nh gi\u00e1 kh\u1ea3 n\u0103ng b\u1ec7nh nh\u00e2n c\u00f3 th\u1ec3 m\u1eafc lao m\u00e0ng n\u00e3o tr\u01b0\u1edbc c\u1ea3 khi c\u00f3 k\u1ebft qu\u1ea3 x\u00e9t nghi\u1ec7m Mtb<\/em>. <\/p>\n\n\n\n

C\u00e1c d\u1ef1 \u0111o\u00e1n c\u1ee7a m\u00f4 h\u00ecnh \u0111\u00e3 \u0111\u01b0\u1ee3c ki\u1ec3m ch\u1ee9ng m\u00f9 v\u1edbi ch\u1ea9n \u0111o\u00e1n th\u1ef1c t\u1ebf c\u1ee7a t\u1eebng b\u1ec7nh nh\u00e2n, v\u00e0 qua \u0111\u00e1nh gi\u00e1 \u0111\u1ed9c l\u1eadp c\u1ee7a c\u00e1c chuy\u00ean gia t\u1ea1i B\u1ec7nh vi\u1ec7n B\u1ec7nh Nhi\u1ec7t \u0111\u1edbi (v\u00e0o th\u1eddi \u0111i\u1ec3m b\u1ec7nh nh\u00e2n qua \u0111\u1eddi ho\u1eb7c \u0111\u01b0\u1ee3c xu\u1ea5t vi\u1ec7n). K\u1ebft qu\u1ea3 cho th\u1ea5y m\u00f4 h\u00ecnh c\u00f3 \u0111\u1ed9 ch\u00ednh x\u00e1c cao (v\u1edbi Di\u1ec7n t\u00edch d\u01b0\u1edbi \u0111\u01b0\u1eddng cong t\u1edbi 94%). M\u00f4 h\u00ecnh n\u00e0y c\u00f3 nhi\u1ec1u tri\u1ec3n v\u1ecdng, \u0111\u1eb7c bi\u1ec7t l\u00e0 \u1edf nh\u1eefng khu v\u1ef1c thi\u1ebfu ngu\u1ed3n l\u1ef1c nh\u01b0 Vi\u1ec7t Nam, n\u01a1i khan hi\u1ebfm c\u00e1c ph\u01b0\u01a1ng ph\u00e1p x\u00e9t nghi\u1ec7m ch\u1ea9n \u0111o\u00e1n ti\u00ean ti\u1ebfn. <\/p>\n\n\n\n

Ph\u00e2n t\u00edch Bayes<\/a> l\u00e0 m\u1ed9t c\u00f4ng c\u1ee5 th\u1ed1ng k\u00ea c\u00f3 th\u1ec3 cung c\u1ea5p c\u00e1i nh\u00ecn r\u00f5 r\u00e0ng h\u01a1n trong nh\u1eefng t\u00ecnh hu\u1ed1ng m\u00e0 c\u00e1c ph\u00e9p \u0111o v\u1eabn c\u00f2n m\u01a1 h\u1ed3 v\u00e0 thi\u1ebfu ch\u00ednh x\u00e1c, v\u00ed d\u1ee5 nh\u01b0 ch\u1ea9n \u0111o\u00e1n lao m\u00e0ng n\u00e3o. Ph\u01b0\u01a1ng ph\u00e1p suy lu\u1eadn tinh vi n\u00e0y d\u1ef1a tr\u00ean vi\u1ec7c t\u1ed5ng h\u1ee3p c\u00e1c th\u00f4ng tin gi\u00e1n ti\u1ebfp – bao g\u1ed3m tri\u1ec7u ch\u1ee9ng v\u00e0 k\u1ebft qu\u1ea3 x\u00e9t nghi\u1ec7m – \u0111\u1ec3 k\u1ebft lu\u1eadn v\u1ec1 b\u1ec7nh l\u00fd c\u1ee5 th\u1ec3. <\/p>\n\n\n\n

C\u00e1ch ti\u1ebfp c\u1eadn n\u00e0y cho ph\u00e9p c\u00e1c b\u00e1c s\u0129 \u0111\u01b0a ra quy\u1ebft \u0111\u1ecbnh s\u00e1ng su\u1ed1t h\u01a1n v\u1ec1 ch\u1ea9n \u0111o\u00e1n v\u00e0 \u0111i\u1ec1u tr\u1ecb, ngay c\u1ea3 khi kh\u00f4ng c\u00f3 k\u1ebft qu\u1ea3 x\u00e9t nghi\u1ec7m tr\u1ef1c ti\u1ebfp ho\u1eb7c r\u00f5 r\u00e0ng. \u0110\u00e2y l\u00e0 ph\u01b0\u01a1ng ph\u00e1p li\u00ean k\u1ebft c\u00e1c d\u1eef li\u1ec7u ri\u00eang l\u1ebb th\u00e0nh m\u1ed9t h\u00ecnh \u1ea3nh t\u1ed5ng th\u1ec3, r\u00f5 r\u00e0ng h\u01a1n v\u1ec1 t\u00ecnh tr\u1ea1ng s\u1ee9c kh\u1ecfe c\u1ee7a b\u1ec7nh nh\u00e2n, th\u00f4ng qua vi\u1ec7c s\u1eed d\u1ee5ng k\u1ebft h\u1ee3p th\u00f4ng tin th\u1ef1c t\u1ebf v\u00e0 ki\u1ebfn th\u1ee9c \u0111\u00e3 t\u00edch l\u0169y t\u1eeb kinh nghi\u1ec7m tr\u01b0\u1edbc \u0111\u00f3. <\/p>\n\n\n\n

\u00c1p d\u1ee5ng trong th\u1ef1c h\u00e0nh l\u00e2m s\u00e0ng <\/h2>\n\n\n\n

Nghi\u00ean c\u1ee9u \u0111\u00e3 ph\u00e1t hi\u1ec7n ra r\u1eb1ng c\u00e1c y\u1ebfu t\u1ed1 nh\u01b0 nhi\u1ec5m HIV, b\u1ec7nh lao ngo\u00e0i ph\u1ed5i, th\u1eddi gian xu\u1ea5t hi\u1ec7n tri\u1ec7u ch\u1ee9ng k\u00e9o d\u00e0i, c\u00f9ng v\u1edbi s\u1ef1 t\u0103ng s\u1ed1 l\u01b0\u1ee3ng t\u1ebf b\u00e0o lympho trong d\u1ecbch n\u00e3o t\u1ee7y, \u0111\u1ec1u l\u00e0 nh\u1eefng ch\u1ec9 b\u00e1o l\u00e0m t\u0103ng nguy c\u01a1 m\u1eafc b\u1ec7nh lao m\u00e0ng n\u00e3o. Ngo\u00e0i ra, nghi\u00ean c\u1ee9u c\u00f2n ch\u1ec9 ra r\u1eb1ng b\u1ec7nh nh\u00e2n m\u1eafc lao m\u00e0ng n\u00e3o \u0111\u1ed3ng th\u1eddi nhi\u1ec5m HIV th\u01b0\u1eddng c\u00f3 s\u1ed1 l\u01b0\u1ee3ng t\u1ebf b\u00e0o lympho trong d\u1ecbch n\u00e3o t\u1ee7y (CSF) gi\u1ea3m v\u00e0 n\u1ed3ng \u0111\u1ed9 protein CSF cao h\u01a1n, \u0111i\u1ec1u n\u00e0y li\u00ean quan \u0111\u1ebfn m\u1ee9c \u0111\u1ed9 nhi\u1ec5m mycobacteria trong c\u01a1 th\u1ec3 cao h\u01a1n. <\/p>\n\n\n\n

M\u00f4 h\u00ecnh ch\u1ea9n \u0111o\u00e1n n\u00e0y c\u0169ng \u0111\u01b0\u1ee3c \u0111\u01a1n gi\u1ea3n h\u00f3a b\u1eb1ng c\u00e1ch s\u1eed d\u1ee5ng b\u1ea3ng t\u00ednh \u0111i\u1ec3m th\u1ee7 c\u00f4ng d\u1ef1a tr\u00ean th\u00f4ng tin l\u00e2m s\u00e0ng v\u00e0 h\u00ecnh \u1ea3nh ch\u1ee5p X-quang ng\u1ef1c \u0111\u1ec3 ti\u1ebfn h\u00e0nh s\u00e0ng l\u1ecdc s\u1edbm. Ph\u01b0\u01a1ng ph\u00e1p n\u00e0y c\u00f3 th\u1ec3 r\u1ea5t h\u1eefu d\u1ee5ng t\u1ea1i c\u00e1c khu v\u1ef1c kh\u00f4ng c\u00f3 kh\u1ea3 n\u0103ng ti\u1ebfn h\u00e0nh ph\u00e2n t\u00edch d\u1ecbch n\u00e3o t\u1ee7y m\u1ed9t c\u00e1ch to\u00e0n di\u1ec7n. <\/p>\n\n\n\n

C\u1ea3 hai m\u00f4 h\u00ecnh ch\u1ea9n \u0111o\u00e1n \u0111\u1ec1u c\u00f3 s\u1eb5n d\u01b0\u1edbi h\u00ecnh th\u1ee9c \u1ee9ng d\u1ee5ng web ti\u00ean ti\u1ebfn<\/a>, gi\u00fap \u0111\u01b0a c\u00f4ng c\u1ee5 m\u1edbi n\u00e0y \u0111\u1ebfn tay c\u00e1c y b\u00e1c s\u0129 l\u00e2m s\u00e0ng \u1edf m\u1ecdi n\u01a1i tr\u00ean th\u1ebf gi\u1edbi. \u1ee8ng d\u1ee5ng web n\u00e0y kh\u00f4ng ch\u1ec9 d\u1ec5 s\u1eed d\u1ee5ng m\u00e0 c\u00f2n t\u01b0\u01a1ng th\u00edch v\u1edbi nhi\u1ec1u lo\u1ea1i thi\u1ebft b\u1ecb, \u0111\u1ea3m b\u1ea3o r\u1eb1ng c\u00e1c b\u00e1c s\u0129 c\u00f3 th\u1ec3 \u00e1p d\u1ee5ng c\u00f4ng c\u1ee5 n\u00e0y m\u1ed9t c\u00e1ch hi\u1ec7u qu\u1ea3 trong vi\u1ec7c ch\u1ea9n \u0111o\u00e1n lao m\u00e0ng n\u00e3o, t\u1eeb \u0111\u00f3 t\u0103ng t\u1ed1c \u0111\u1ed9 x\u1eed l\u00fd v\u00e0 c\u1ea3i thi\u1ec7n kh\u1ea3 n\u0103ng ph\u1ee5c h\u1ed3i c\u1ee7a b\u1ec7nh nh\u00e2n. <\/p>\n\n\n\n

Ti\u1ebfn s\u0129 \u0110\u1ed3ng H\u1eefu Kh\u00e1nh Tr\u00ecnh<\/a>, t\u00e1c gi\u1ea3 th\u1ee9 nh\u1ea5t c\u1ee7a nghi\u00ean c\u1ee9u, nh\u1ea5n m\u1ea1nh v\u1ec1 ti\u1ec1m n\u0103ng c\u1ee7a m\u00f4 h\u00ecnh n\u00e0y: “C\u00f4ng c\u1ee5 ch\u1ea9n \u0111o\u00e1n n\u00e0y c\u00f3 ti\u1ec1m n\u0103ng tr\u1edf th\u00e0nh tr\u1ee3 l\u00fd \u0111\u1eafc l\u1ef1c cho c\u00e1c b\u00e1c s\u0129 l\u00e2m s\u00e0ng. Vi\u1ec7c ch\u1ea9n \u0111o\u00e1n nhanh ch\u00f3ng v\u00e0 ch\u00ednh x\u00e1c b\u1ec7nh \u0111\u1ea3m b\u1ea3o vi\u1ec7c ti\u1ebfn h\u00e0nh \u0111i\u1ec1u tr\u1ecb \u0111\u00fang \u0111\u1eafn v\u00e0 k\u1ecbp th\u1eddi, v\u00e0 \u0111\u00e2y c\u00f3 th\u1ec3 l\u00e0 ch\u00eca kh\u00f3a c\u1ee9u s\u1ed1ng cho b\u1ec7nh nh\u00e2n.” <\/p>\n\n\n\n

\u0110\u1ec3 \u0111\u1ecdc to\u00e0n b\u1ed9 nghi\u00ean c\u1ee9u, truy c\u1eadp: A novel diagnostic model for tuberculous meningitis using Bayesian latent class analysis<\/a> <\/p>\n\n\n\n

Nghi\u00ean c\u1ee9u \u0111\u01b0\u1ee3c t\u00e0i tr\u1ee3 b\u1edfi qu\u1ef9 Wellcome<\/a>. <\/p>\n","protected":false},"excerpt":{"rendered":"

Nh\u00f3m nghi\u00ean c\u1ee9u t\u1ea1i OUCRU \u0111\u00e3 ph\u00e1t tri\u1ec3n m\u1ed9t ph\u01b0\u01a1ng ph\u00e1p ch\u1ea9n \u0111o\u00e1n m\u1edbi cho b\u1ec7nh lao m\u00e0ng n\u00e3o (TBM) \u1edf ng\u01b0\u1eddi l\u1edbn. Ph\u01b0\u01a1ng ph\u00e1p n\u00e0y kh\u00f4ng d\u1ef1a v\u00e0o c\u00e1c x\u00e9t nghi\u1ec7m vi sinh truy\u1ec1n th\u1ed1ng m\u00e0 s\u1eed d\u1ee5ng ph\u00e2n t\u00edch Bayesian ti\u1ec1m \u1ea9n \u0111\u1ec3 n\u00e2ng cao \u0111\u1ed9 ch\u00ednh x\u00e1c trong vi\u1ec7c x\u00e1c \u0111\u1ecbnh b\u1ec7nh. Ph\u01b0\u01a1ng ph\u00e1p m\u1edbi n\u00e0y, v\u1eeba \u0111\u01b0\u1ee3c c\u00f4ng b\u1ed1 trong t\u1ea1p ch\u00ed BMC Infectious Diseases, m\u1edf ra tri\u1ec3n v\u1ecdng c\u1ea3i thi\u1ec7n kh\u1ea3 n\u0103ng ph\u00e1t hi\u1ec7n v\u00e0 \u0111i\u1ec1u tr\u1ecb m\u1ed9t trong nh\u1eefng bi\u1ebfn ch\u1ee9ng nguy hi\u1ec3m nh\u1ea5t c\u1ee7a b\u1ec7nh lao. <\/p>\n","protected":false},"author":28,"featured_media":36655,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":"","_wp_rev_ctl_limit":""},"categories":[291],"tags":[],"class_list":["post-36663","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-oucru-ho-chi-minh"],"acf":[],"yoast_head":"\nNghi\u00ean c\u1ee9u c\u1ee7a OUCRU ph\u00e1t tri\u1ec3n c\u00f4ng c\u1ee5 ch\u1ea9n \u0111o\u00e1n m\u1edbi cho lao m\u00e0ng n\u00e3o \u1edf ng\u01b0\u1eddi l\u1edbn - OUCRU<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.oucru.org\/vi\/chan-doan-lao-mang-nao\/\" \/>\n<meta property=\"og:locale\" content=\"vi_VN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Nghi\u00ean c\u1ee9u c\u1ee7a OUCRU ph\u00e1t tri\u1ec3n c\u00f4ng c\u1ee5 ch\u1ea9n \u0111o\u00e1n m\u1edbi cho lao m\u00e0ng n\u00e3o \u1edf ng\u01b0\u1eddi l\u1edbn - OUCRU\" \/>\n<meta property=\"og:description\" content=\"Nh\u00f3m nghi\u00ean c\u1ee9u t\u1ea1i OUCRU \u0111\u00e3 ph\u00e1t tri\u1ec3n m\u1ed9t ph\u01b0\u01a1ng ph\u00e1p ch\u1ea9n \u0111o\u00e1n m\u1edbi cho b\u1ec7nh lao m\u00e0ng n\u00e3o (TBM) \u1edf ng\u01b0\u1eddi l\u1edbn. 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