{"id":41284,"date":"2024-11-06T10:25:08","date_gmt":"2024-11-06T03:25:08","guid":{"rendered":"https:\/\/www.oucru.org\/?p=41284"},"modified":"2024-11-06T11:45:04","modified_gmt":"2024-11-06T04:45:04","slug":"chan-doan-som-tbm-collab-lab","status":"publish","type":"post","link":"https:\/\/www.oucru.org\/vi\/chan-doan-som-tbm-collab-lab\/","title":{"rendered":"Ch\u1ea9n \u0111o\u00e1n s\u1edbm TBM b\u1eb1ng c\u00f4ng ngh\u1ec7 gen c\u00f3 th\u1ec3 gi\u00fap n\u00e2ng cao ch\u1ea5t l\u01b0\u1ee3ng cu\u1ed9c s\u1ed1ng c\u1ee7a b\u1ec7nh nh\u00e2n"},"content":{"rendered":"\n

Vi\u1ec7t Nam v\u1eabn l\u00e0 qu\u1ed1c gia c\u00f3 g\u00e1nh n\u1eb7ng b\u1ec7nh lao cao, trong \u0111\u00f3 lao m\u00e0ng n\u00e3o th\u01b0\u1eddng kh\u00f3 ch\u1ea9n \u0111o\u00e1n, th\u01b0\u1eddng d\u1eabn \u0111\u1ebfn di ch\u1ee9ng th\u1ea7n kinh nghi\u00eam tr\u1ecdng \u1edf b\u1ec7nh nh\u00e2n.<\/p>\n\n\n\n

Trong s\u1ed1 c\u00e1c b\u1ec7nh li\u00ean quan \u0111\u1ebfn lao, lao m\u00e0ng n\u00e3o c\u00f3 t\u1ef7 l\u1ec7 t\u1eed vong cao nh\u1ea5t \u1edf tr\u1ebb s\u01a1 sinh, dao \u0111\u1ed9ng t\u1eeb 20-50%. M\u1ed9t trong nh\u1eefng th\u00e1ch th\u1ee9c l\u1edbn nh\u1ea5t trong vi\u1ec7c ch\u1ea9n \u0111o\u00e1n lao m\u00e0ng n\u00e3o l\u00e0 c\u00e1c tri\u1ec7u ch\u1ee9ng l\u00e2m s\u00e0ng c\u1ee7a n\u00f3 kh\u00e1 gi\u1ed1ng v\u1edbi c\u00e1c b\u1ec7nh nhi\u1ec5m tr\u00f9ng th\u1ea7n kinh trung \u01b0\u01a1ng kh\u00e1c.<\/p>\n\n\n\n

M\u1eb7c d\u00f9 l\u00e0 b\u1ec7nh nguy hi\u1ec3m, lao m\u00e0ng n\u00e3o c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c ph\u00f2ng ng\u1eeba b\u1eb1ng v\u1eafc-xin BCG (Bacille Calmette-Gu\u00e9rin). Tuy nhi\u00ean, trong m\u1ed9t kh\u1ea3o s\u00e1t nhanh t\u1ea1i b\u1ec7nh vi\u1ec7n, nhi\u1ec1u ph\u1ee5 huynh \u0111\u00e3 th\u1eeba nh\u1eadn kh\u00f4ng nh\u1edb con \u0111\u00e3 ti\u00eam ch\u1ee7ng ho\u1eb7c \u0111\u00e3 ti\u00eam \u0111\u1ee7 hay ch\u01b0a.<\/p>\n\n\n\n

V\u1edbi m\u1ee5c ti\u00eau t\u1eadp trung v\u00e0o c\u00e1c v\u1ea5n \u0111\u1ec1 s\u1ee9c kh\u1ecfe to\u00e0n c\u1ea7u, Collab Lab<\/a>, s\u00e1ng ki\u1ebfn c\u1ee7a nh\u00f3m \u0110\u1ea1i s\u1ee9 K\u1ebft n\u1ed1i Khoa h\u1ecdc<\/a> do nh\u00f3m K\u1ebft n\u1ed1i Khoa h\u1ecdc v\u1edbi C\u00f4ng ch\u00fang v\u00e0 C\u1ed9ng \u0111\u1ed3ng<\/a> h\u1ed7 tr\u1ee3 th\u1ef1c hi\u1ec7n, \u0111\u00e3 ch\u1ecdn b\u00e0i b\u00e1o khoa h\u1ecdc v\u1ec1 nh\u1eefng ph\u00e1t hi\u1ec7n m\u1edbi trong ph\u01b0\u01a1ng ph\u00e1p ch\u1ea9n \u0111o\u00e1n s\u1edbm lao m\u00e0ng n\u00e3o. Video ho\u1ea1t h\u00ecnh h\u00f3a gi\u1ea3i th\u00edch b\u00e0i b\u00e1o khoa h\u1ecdc n\u00e0y gi\u00fap g\u00f3p ph\u1ea7n n\u00e2ng cao nh\u1eadn th\u1ee9c v\u1ec1 b\u1ec7nh lao n\u00f3i chung, \u0111\u1eb7c bi\u1ec7t l\u00e0 lao m\u00e0ng n\u00e3o, v\u00e0 t\u1ea7m quan tr\u1ecdng c\u1ee7a vi\u1ec7c ti\u00eam v\u1eafc-xin BCG cho tr\u1ebb em.<\/p>\n\n\n\n

“T\u00f4i t\u01b0\u1edfng lao ch\u1ec9 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn ph\u1ed5i”.<\/h4>\n\n\n\n

Theo b\u00e1o c\u00e1o n\u0103m 2020 c\u1ee7a T\u1ed5 ch\u1ee9c Y t\u1ebf Th\u1ebf gi\u1edbi (WHO), Vi\u1ec7t Nam x\u1ebfp th\u1ee9 10 trong s\u1ed1 30 qu\u1ed1c gia c\u00f3 s\u1ed1 ca m\u1eafc lao cao nh\u1ea5t v\u00e0 \u0111\u1ee9ng th\u1ee9 11 v\u1ec1 g\u00e1nh n\u1eb7ng b\u1ec7nh lao kh\u00e1ng \u0111a thu\u1ed1c tr\u00ean to\u00e0n c\u1ea7u. H\u00e0ng n\u0103m, Vi\u1ec7t Nam ghi nh\u1eadn h\u01a1n 172.000 ca m\u1eafc lao v\u00e0 10.400 ca t\u1eed vong do b\u1ec7nh n\u00e0y. Ri\u00eang t\u1ea1i Th\u00e0nh ph\u1ed1 H\u1ed3 Ch\u00ed Minh, 6 th\u00e1ng \u0111\u1ea7u n\u0103m 2022 \u0111\u00e3 ghi nh\u1eadn h\u01a1n 8.434 ca m\u1eafc lao, t\u0103ng h\u01a1n 33% so v\u1edbi c\u00f9ng k\u1ef3 n\u0103m 2021(2)<\/sup>.<\/p>\n\n\n\n

Lao m\u00e0ng n\u00e3o xu\u1ea5t hi\u1ec7n khi vi khu\u1ea9n lao x\u00e2m nh\u1eadp v\u00e0o c\u01a1 th\u1ec3 v\u00e0 theo \u0111\u01b0\u1eddng m\u00e1u \u0111\u1ebfn t\u1ea5n c\u00f4ng n\u00e3o v\u00e0 m\u00e0ng n\u00e3o. BS Tr\u01b0\u01a1ng H\u1eefu Khanh, Ph\u00f3 ch\u1ee7 t\u1ecbch Li\u00ean Chi h\u1ed9i B\u1ec7nh truy\u1ec1n nhi\u1ec5m TP HCM, cho bi\u1ebft lao m\u00e0ng n\u00e3o c\u00f3 s\u1ed1 t\u1eed vong cao nh\u1ea5t trong c\u00e1c b\u1ec7nh l\u00fd v\u1ec1 lao \u1edf tr\u1ebb s\u01a1 sinh, v\u1edbi t\u1ef7 l\u1ec7 t\u1eed vong t\u1eeb 20-50%.<\/p>\n\n\n\n

H\u01a1n 50% b\u1ec7nh nh\u00e2n qua kh\u1ecfi v\u1eabn ph\u1ea3i ch\u1ecbu nh\u1eefng di ch\u1ee9ng th\u1ea7n kinh nghi\u00eam tr\u1ecdng nh\u01b0 b\u1ea1i n\u00e3o, li\u1ec7t chi, \u0111\u1ed9ng kinh, c\u00e2m, \u0111i\u1ebfc ho\u1eb7c m\u00f9. B\u1ec7nh nh\u00e2n c\u0169ng c\u00f3 th\u1ec3 c\u00f3 nh\u1eefng bi\u1ebfn ch\u1ee9ng n\u1eb7ng n\u1ec1 v\u1ec1 l\u00e2u d\u00e0i nh\u01b0 sa s\u00fat tr\u00ed tu\u1ec7, t\u1ed5n th\u01b0\u01a1ng th\u1ea7n kinh v\u00e0 r\u1ed1i lo\u1ea1n t\u00e2m th\u1ea7n(1)<\/sup>.<\/p>\n\n\n\n

M\u1ed9t trong nh\u1eefng th\u00e1ch th\u1ee9c l\u1edbn nh\u1ea5t trong vi\u1ec7c ch\u1ea9n \u0111o\u00e1n lao m\u00e0ng n\u00e3o l\u00e0 b\u1ec7nh kh\u1edfi ph\u00e1t b\u1edfi c\u00e1c tri\u1ec7u ch\u1ee9ng kh\u00f4ng \u0111\u1eb7c hi\u1ec7u, kh\u00e1 gi\u1ed1ng v\u1edbi c\u00e1c b\u1ec7nh nhi\u1ec5m tr\u00f9ng h\u1ec7 th\u1ea7n kinh trung \u01b0\u01a1ng kh\u00e1c. N\u1ebfu \u0111\u01b0\u1ee3c ph\u00e1t hi\u1ec7n s\u1edbm trong ch\u1ea9n \u0111o\u00e1n v\u00e0 \u0111i\u1ec1u tr\u1ecb lao m\u00e0ng n\u00e3o, t\u1ec9 l\u1ec7 t\u1eed vong v\u00e0 di ch\u1ee9ng do b\u1ec7nh c\u00f3 kh\u1ea3 n\u0103ng gi\u1ea3m \u0111i \u0111\u00e1ng k\u1ec3.<\/p>\n\n\n\n

Ph\u00e1t hi\u1ec7n m\u1edbi mang t\u00ednh \u0111\u1ed9t ph\u00e1 trong ch\u1ea9n \u0111o\u00e1n s\u1edbm lao m\u00e0ng n\u00e3o s\u1eed d\u1ee5ng c\u00f4ng ngh\u1ec7 gen.<\/strong><\/p>\n\n\n\n

C\u00e1c b\u00e1o c\u00e1o g\u1ea7n \u0111\u00e2y \u0111\u00e3 ph\u00e1t hi\u1ec7n m\u1ed9t s\u1ed1 gen nh\u1ea5t \u0111\u1ecbnh\u2014GPB5, DUSP3 v\u00e0 KLF2 \u2014 c\u00f3 nh\u1eefng thay \u0111\u1ed5i bi\u1ec3u hi\u1ec7n \u0111\u00e1ng ch\u00fa \u00fd \u1edf b\u1ec7nh nh\u00e2n m\u1eafc lao ph\u1ed5i. Tuy nhi\u00ean, li\u1ec7u nh\u1eefng d\u1ea5u hi\u1ec7u gen n\u00e0y c\u00f3 \u0111\u1ee7 \u0111\u00e1ng tin c\u1eady \u0111\u1ec3 \u00e1p d\u1ee5ng trong vi\u1ec7c ph\u00e1t tri\u1ec3n c\u00e1c b\u1ed9 c\u00f4ng c\u1ee5 x\u00e9t nghi\u1ec7m lao m\u00e0ng n\u00e3o nhanh v\u00e0 ch\u00ednh x\u00e1c h\u01a1n c\u00e1c lo\u1ea1i x\u00e9t nghi\u1ec7m kh\u00e1c tr\u00ean th\u1ecb tr\u01b0\u1eddng.<\/p>\n\n\n\n

BS Julie Huynh<\/a>, B\u00e1c s\u0129 Nghi\u00ean c\u1ee9u L\u00e2m s\u00e0ng Nhi khoa cho bi\u1ebft, c\u00f4 hi v\u1ecdng nghi\u00ean c\u1ee9u n\u00e0y c\u1ee7a c\u00f4 v\u00e0 c\u00e1c c\u1ed9ng s\u1ef1 s\u1ebd \u0111\u00f3ng g\u00f3p v\u00e0o vi\u1ec7c c\u1ea3i thi\u1ec7n t\u1ed1c \u0111\u1ed9 v\u00e0 \u0111\u1ed9 ch\u00ednh x\u00e1c trong ch\u1ea9n \u0111o\u00e1n lao m\u00e0ng n\u00e3o, t\u1eeb \u0111\u00f3 n\u00e2ng cao ch\u1ea5t l\u01b0\u1ee3ng \u0111i\u1ec1u tr\u1ecb v\u00e0 gi\u1ea3m di ch\u1ee9ng cho b\u1ec7nh nh\u00e2n.<\/p>\n\n\n\n

N\u00e2ng cao nh\u1eadn th\u1ee9c c\u1ee7a c\u1ed9ng \u0111\u1ed3ng v\u1ec1 lao v\u00e0 lao m\u00e0ng n\u00e3o \u0111\u00f3ng vai tr\u00f2 quan tr\u1ecdng trong n\u00e2ng cao t\u1ef7 l\u1ec7 ti\u00eam v\u1eafc-xin BCG \u1edf tr\u1ebb em.<\/p>\n\n\n\n

Trong m\u1ed9t kh\u1ea3o s\u00e1t nhanh, nhi\u1ec1u ph\u1ee5 huynh c\u00f3 tr\u1ebb m\u1eafc lao m\u00e0ng n\u00e3o th\u1eeba nh\u1eadn tr\u1ebb ch\u01b0a \u0111\u01b0\u1ee3c ti\u00eam ng\u1eeba lao, ho\u1eb7c ph\u1ee5 huynh kh\u00f4ng nh\u1edb con \u0111\u00e3 ti\u00eam vaccine ch\u01b0a, hay tr\u1ebb \u0111\u00e3 ti\u00eam nh\u01b0ng v\u1ebft ti\u00eam nh\u1ecf, kh\u00f4ng \u0111\u1ea1t \u0111\u01b0\u1ee3c hi\u1ec7u qu\u1ea3 ph\u00f2ng ng\u1eeba.<\/p>\n\n\n\n

H\u01b0\u1edbng \u0111\u1ebfn m\u1ee5c ti\u00eau gi\u1ea3i th\u00edch m\u1ee9c \u0111\u1ed9 nguy hi\u1ec3m c\u1ee7a lao v\u00e0 lao m\u00e0ng n\u00e3o, \u0111\u1eb7c bi\u1ec7t \u0111\u1ed1i v\u1edbi tr\u1ebb em, \u0111\u1ed3ng th\u1eddi nh\u1ea5n m\u1ea1nh t\u1ea7m quan tr\u1ecdng c\u1ee7a nghi\u00ean c\u1ee9u trong vi\u1ec7c ch\u1ea9n \u0111o\u00e1n s\u1edbm c\u0103n b\u1ec7nh nguy hi\u1ec3m n\u00e0y, nh\u00f3m Collab Lab \u0111\u00e3 ch\u1ecdn m\u1ed9t c\u00e1ch ti\u1ebfp c\u1eadn th\u00fa v\u1ecb v\u00e0 h\u00e0i h\u01b0\u1edbc \u0111\u1ec3 gi\u1ea3i th\u00edch k\u1ebft qu\u1ea3 nghi\u00ean c\u1ee9u m\u1ed9t c\u00e1ch d\u1ec5 hi\u1ec3u \u0111\u1ed1i v\u1edbi c\u00f4ng ch\u00fang.<\/p>\n\n\n\n

Nh\u00f3m hi v\u1ecdng c\u00e1ch ti\u1ebfp c\u1eadn m\u1edbi l\u1ea1 n\u00e0y s\u1ebd gi\u00fap th\u00f4ng tin nghi\u00ean c\u1ee9u gen ph\u1ee9c t\u1ea1p tr\u1edf n\u00ean d\u1ec5 ti\u1ebfp c\u1eadn h\u01a1n \u0111\u1ed1i v\u1edbi \u0111\u1ea1i ch\u00fang, \u0111\u1eb7c bi\u1ec7t l\u00e0 nh\u00f3m ng\u01b0\u1eddi tr\u1ebb, nh\u1eefng ng\u01b0\u1eddi c\u00f3 th\u1ec3 \u0111\u00f3ng vai tr\u00f2 quy\u1ebft \u0111\u1ecbnh trong vi\u1ec7c c\u1ea3i thi\u1ec7n t\u1ef7 l\u1ec7 ti\u00eam ch\u1ee7ng v\u1eafc-xin lao t\u1ea1i Vi\u1ec7t Nam.<\/p>\n\n\n\n

T\u00e0i li\u1ec7u tham kh\u1ea3o: <\/strong><\/p>\n\n\n\n

1. Huynh J, Nhat LHT, Bao NLH, Hai HT, Thu DDA, Tram TTB, Dung VTM, Vinh DD, Ngoc NM, Donovan J, Phu NH, Van Thanh D, Thu NTA, Bang ND, Ha DTM, Nghia HDT, Van Tan L, Van LH, Thwaites G, Thuong NTT. The Ability of a 3-Gene Host Signature in Blood to Distinguish Tuberculous Meningitis From Other Brain Infections. J Infect Dis. 2024 Aug 16;230(2):e268-e278. doi: 10.1093\/infdis\/jiad606. PMID: 38169323; PMCID: PMC11326836. <\/p>\n\n\n\n

2. https:\/\/vnexpress.net\/who-canh-bao-so-ca-benh-lao-tang-cao-ky-luc-4810615.html<\/a>  <\/p>\n\n\n\n

3, 4. https:\/\/vnexpress.net\/nhieu-em-be-mac-lao-mang-nao-nhap-vien-4546696.html<\/a> <\/p>\n","protected":false},"excerpt":{"rendered":"

Vi\u1ec7t Nam v\u1eabn l\u00e0 qu\u1ed1c gia c\u00f3 g\u00e1nh n\u1eb7ng b\u1ec7nh lao cao, trong \u0111\u00f3 lao m\u00e0ng n\u00e3o th\u01b0\u1eddng kh\u00f3 ch\u1ea9n \u0111o\u00e1n, th\u01b0\u1eddng d\u1eabn \u0111\u1ebfn di ch\u1ee9ng th\u1ea7n kinh nghi\u00eam tr\u1ecdng […]<\/p>\n","protected":false},"author":32,"featured_media":44353,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":"","_wp_rev_ctl_limit":""},"categories":[291],"tags":[589],"class_list":["post-41284","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-oucru-ho-chi-minh","tag-ket-noi-khoa-hoc-voi-cong-chung"],"acf":[],"yoast_head":"\nCh\u1ea9n \u0111o\u00e1n s\u1edbm TBM b\u1eb1ng c\u00f4ng ngh\u1ec7 gen c\u00f3 th\u1ec3 gi\u00fap n\u00e2ng cao ch\u1ea5t l\u01b0\u1ee3ng cu\u1ed9c s\u1ed1ng c\u1ee7a b\u1ec7nh nh\u00e2n - OUCRU<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.oucru.org\/vi\/chan-doan-som-tbm-collab-lab\/\" \/>\n<meta property=\"og:locale\" content=\"vi_VN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Ch\u1ea9n \u0111o\u00e1n s\u1edbm TBM b\u1eb1ng c\u00f4ng ngh\u1ec7 gen c\u00f3 th\u1ec3 gi\u00fap n\u00e2ng cao ch\u1ea5t l\u01b0\u1ee3ng cu\u1ed9c s\u1ed1ng c\u1ee7a b\u1ec7nh nh\u00e2n - 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