{"id":55281,"date":"2026-03-24T14:11:28","date_gmt":"2026-03-24T07:11:28","guid":{"rendered":"https:\/\/www.oucru.org\/oucru-trien-khai-chuong-trinh-nghien-cuu-quoc-te-nham-tim-kiem-chien-luoc-dieu-tri-moi-cho-lao-mang-nao\/"},"modified":"2026-03-24T16:31:27","modified_gmt":"2026-03-24T09:31:27","slug":"oucru-trien-khai-chuong-trinh-nghien-cuu-quoc-te-nham-tim-kiem-chien-luoc-dieu-tri-moi-cho-lao-mang-nao","status":"publish","type":"post","link":"https:\/\/www.oucru.org\/vi\/oucru-trien-khai-chuong-trinh-nghien-cuu-quoc-te-nham-tim-kiem-chien-luoc-dieu-tri-moi-cho-lao-mang-nao\/","title":{"rendered":"OUCRU tri\u1ec3n khai ch\u01b0\u01a1ng tr\u00ecnh nghi\u00ean c\u1ee9u qu\u1ed1c t\u1ebf nh\u1eb1m t\u00ecm ki\u1ebfm chi\u1ebfn l\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb m\u1edbi cho lao m\u00e0ng n\u00e3o"},"content":{"rendered":"

Lao m\u00e0ng n\u00e3o l\u00e0 m\u1ed9t trong nh\u1eefng th\u1ec3 lao nghi\u00eam tr\u1ecdng nh\u1ea5t. D\u00f9 \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb, c\u0103n b\u1ec7nh n\u00e0y v\u1eabn c\u01b0\u1edbp \u0111i sinh m\u1ea1ng c\u1ee7a 30% \u0111\u1ebfn 50% ng\u01b0\u1eddi m\u1eafc. T\u1eeb gi\u1eefa th\u1ebf k\u1ef7 20, c\u00e1c b\u00e1c s\u0129 v\u1eabn ph\u1ea3i d\u1ef1a tr\u00ean m\u1ed9t ph\u01b0\u01a1ng ph\u00e1p ti\u1ebfp c\u1eadn c\u01a1 b\u1ea3n: s\u1eed d\u1ee5ng kh\u00e1ng sinh \u0111\u1ec3 ti\u00eau di\u1ec7t vi khu\u1ea9n v\u00e0 corticosteroid \u0111\u1ec3 gi\u1ea3m t\u00ecnh tr\u1ea1ng vi\u00eam n\u00e3o nguy hi\u1ec3m do nhi\u1ec5m tr\u00f9ng g\u00e2y ra. <\/p>\n

Tuy nhi\u00ean, c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng g\u1ea7n \u0111\u00e2y c\u1ee7a OUCRU \u2014 bao g\u1ed3m HARVEST<\/a> (NEJM, th\u00e1ng 12\/2025); SURE<\/a> (ch\u01b0a c\u00f4ng b\u1ed1); ACT HIV<\/a> (NEJM, th\u00e1ng 10\/2023); LAST ACT <\/a>(Nat Med, th\u00e1ng 1\/2026) \u2014 \u0111\u00e3 ch\u1ec9 ra r\u1eb1ng ph\u01b0\u01a1ng ph\u00e1p n\u00e0y l\u00e0 ch\u01b0a \u0111\u1ee7. Vi\u1ec7c t\u0103ng li\u1ec1u kh\u00e1ng sinh kh\u00f4ng c\u1ea3i thi\u1ec7n ti\u00ean l\u01b0\u1ee3ng \u0111i\u1ec1u tr\u1ecb, trong khi hi\u1ec7u qu\u1ea3 c\u1ee7a corticosteroid trong vi\u1ec7c ki\u1ec3m so\u00e1t ph\u1ea3n \u1ee9ng vi\u00eam v\u00e0 mang l\u1ea1i l\u1ee3i \u00edch l\u00e2m s\u00e0ng cho \u0111a s\u1ed1 b\u1ec7nh nh\u00e2n v\u1eabn c\u00f2n h\u1ea1n ch\u1ebf. Th\u1ef1c t\u1ebf n\u00e0y \u0111\u1eb7t ra y\u00eau c\u1ea7u c\u1ea5p thi\u1ebft v\u1ec1 m\u1ed9t h\u01b0\u1edbng \u0111i m\u1edbi trong nghi\u00ean c\u1ee9u v\u00e0 \u0111i\u1ec1u tr\u1ecb. <\/p>\n

C\u01a1 h\u1ed9i \u0111\u1ed9t ph\u00e1 <\/h4>\n

Hi\u1ec7n nay, c\u01a1 h\u1ed9i \u0111\u1ec3 c\u1ea3i thi\u1ec7n vi\u1ec7c \u0111i\u1ec1u tr\u1ecb lao m\u00e0ng n\u00e3o \u0111ang m\u1edf ra r\u00f5 r\u1ec7t. S\u1ef1 xu\u1ea5t hi\u1ec7n c\u1ee7a h\u00e0ng lo\u1ea1t thu\u1ed1c ch\u1ed1ng lao m\u1edbi c\u00f3 kh\u1ea3 n\u0103ng ti\u00eau di\u1ec7t vi khu\u1ea9n nhanh h\u01a1n c\u00e1c lo\u1ea1i thu\u1ed1c hi\u1ec7n t\u1ea1i. \u0110\u1ed3ng th\u1eddi, c\u00e1c lo\u1ea1i thu\u1ed1c kh\u00e1ng vi\u00eam tr\u00fang \u0111\u00edch c\u0169ng h\u1ee9a h\u1eb9n ki\u1ec3m so\u00e1t t\u00ecnh tr\u1ea1ng vi\u00eam n\u00e3o t\u1ed1t h\u01a1n so v\u1edbi ti\u00eau chu\u1ea9n \u0111i\u1ec1u tr\u1ecb b\u1eb1ng corticosteroid hi\u1ec7n nay. <\/p>\n

D\u00f9 v\u1eady, nh\u1eefng c\u01a1 h\u1ed9i n\u00e0y \u0111ang b\u1ecb c\u1ea3n tr\u1edf b\u1edfi ba l\u1ed7 h\u1ed5ng l\u1edbn: s\u1ef1 hi\u1ec3u bi\u1ebft c\u00f2n h\u1ea1n ch\u1ebf v\u1ec1 c\u01a1 ch\u1ebf b\u1ec7nh sinh v\u00e0 d\u01b0\u1ee3c l\u00fd; thi\u1ebfu c\u00e1c m\u00f4 h\u00ecnh \u0111\u1ed9ng v\u1eadt c\u00f3 kh\u1ea3 n\u0103ng d\u1ef1 b\u00e1o ch\u00ednh x\u00e1c hi\u1ec7u qu\u1ea3 c\u1ee7a thu\u1ed1c tr\u00ean ng\u01b0\u1eddi; v\u00e0 s\u1ef1 v\u1eafng b\u00f3ng c\u1ee7a c\u00e1c d\u1ea5u \u1ea5n sinh h\u1ecdc (biomarkers) \u0111\u00e1ng tin c\u1eady \u0111\u1ec3 \u0111\u00e1nh gi\u00e1 m\u1ee9c \u0111\u1ed9 th\u00e0nh c\u00f4ng c\u1ee7a qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb. <\/p>\n

M\u1ed9t ch\u01b0\u01a1ng tr\u00ecnh nghi\u00ean c\u1ee9u quy m\u00f4 l\u1edbn, \u0111\u01b0\u1ee3c h\u1ed7 tr\u1ee3 b\u1edfi Gi\u1ea3i th\u01b0\u1edfng Kh\u00e1m ph\u00e1 (Discovery Award)<\/a> tr\u1ecb gi\u00e1 5 tri\u1ec7u B\u1ea3ng t\u1eeb qu\u1ef9 Wellcome trong v\u00f2ng 5 n\u0103m, s\u1ebd t\u1eadp trung l\u1ea5p \u0111\u1ea7y nh\u1eefng kho\u1ea3ng tr\u1ed1ng \u0111\u00f3. D\u1ef1 \u00e1n do Gi\u00e1o s\u01b0 Guy Thwaites<\/a> t\u1eeb \u0110\u1ea1i h\u1ecdc Oxford <\/a>d\u1eabn d\u1eaft, quy t\u1ee5 \u0111\u1ed9i ng\u0169 chuy\u00ean gia qu\u1ed1c t\u1ebf t\u1eeb OUCRU Vi\u1ec7t Nam<\/a>, CIDRI-Africa<\/a> (Nam Phi), V\u01b0\u01a1ng qu\u1ed1c Anh v\u00e0 Hoa K\u1ef3. Ch\u01b0\u01a1ng tr\u00ecnh d\u1ef1 ki\u1ebfn kh\u1edfi \u0111\u1ed9ng v\u00e0o th\u00e1ng 10 n\u0103m 2026. <\/p>\n

\u201c\u0110\u00e2y l\u00e0 th\u1eddi \u0111i\u1ec3m c\u1ef1c k\u1ef3 tri\u1ec3n v\u1ecdng trong l\u0129nh v\u1ef1c nghi\u00ean c\u1ee9u b\u1ec7nh lao, v\u1edbi s\u1ef1 xu\u1ea5t hi\u1ec7n c\u1ee7a c\u00e1c lo\u1ea1i thu\u1ed1c ch\u1ed1ng lao v\u00e0 kh\u00e1ng vi\u00eam m\u1edbi,\u201d Gi\u00e1o s\u01b0 Guy Thwaites chia s\u1ebb. \u201cNh\u01b0ng n\u1ebfu kh\u00f4ng hi\u1ec3u \u0111\u01b0\u1ee3c m\u1ed1i quan h\u1ec7 c\u1ed1t l\u00f5i gi\u1eefa kh\u1ea3 n\u0103ng di\u1ec7t khu\u1ea9n, t\u00ecnh tr\u1ea1ng vi\u00eam v\u00e0 k\u1ebft c\u1ee5c l\u00e2m s\u00e0ng, ch\u00fang ta c\u00f3 nguy c\u01a1 s\u1eed d\u1ee5ng thu\u1ed1c thi\u1ebfu t\u1ed1i \u01b0u v\u00e0 b\u1ecf l\u1ee1 c\u01a1 h\u1ed9i c\u1ee9u s\u1ed1ng b\u1ec7nh nh\u00e2n kh\u1ecfi c\u0103n b\u1ec7nh nguy hi\u1ec3m n\u00e0y.\u201d <\/p>\n

N\u1ed9i dung nghi\u00ean c\u1ee9u <\/h4>\n

\u0110\u1ed9i ng\u0169 nghi\u00ean c\u1ee9u s\u1ebd x\u00e2y d\u1ef1ng m\u1ed9t n\u1ec1n t\u1ea3ng kh\u00e1m ph\u00e1 v\u00e0 ph\u00e1t tri\u1ec3n c\u00e1c chi\u1ebfn l\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb m\u1edbi cho lao m\u00e0ng n\u00e3o, k\u1ebft n\u1ed1i gi\u1eefa y h\u1ecdc th\u1ef1c nghi\u1ec7m tr\u00ean ng\u01b0\u1eddi t\u1ea1i Vi\u1ec7t Nam v\u00e0 Nam Phi v\u1edbi c\u00e1c m\u00f4 h\u00ecnh \u0111\u1ed9ng v\u1eadt t\u1ea1i Hoa K\u1ef3. <\/p>\n

Trong nghi\u00ean c\u1ee9u tr\u00ean ng\u01b0\u1eddi, nh\u00f3m s\u1ebd th\u1eed nghi\u1ec7m 4 ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb tr\u00ean 160 ng\u01b0\u1eddi tr\u01b0\u1edfng th\u00e0nh m\u1eafc lao m\u00e0ng n\u00e3o: bao g\u1ed3m hai ph\u00e1c \u0111\u1ed3 kh\u00e1ng lao m\u1ea1nh ch\u1ee9a bedaquiline v\u00e0 hai lo\u1ea1i thu\u1ed1c nh\u1eafm tr\u1ef1c ti\u1ebfp v\u00e0o t\u00ecnh tr\u1ea1ng vi\u00eam n\u00e3o thay v\u00ec vi khu\u1ea9n. Nghi\u00ean c\u1ee9u nh\u1eb1m \u0111\u1ecbnh l\u01b0\u1ee3ng m\u1ed1i li\u00ean h\u1ec7 gi\u1eefa n\u1ed3ng \u0111\u1ed9 thu\u1ed1c trong c\u01a1 th\u1ec3, kh\u1ea3 n\u0103ng di\u1ec7t khu\u1ea9n, m\u1ee9c \u0111\u1ed9 vi\u00eam v\u00e0 k\u1ebft qu\u1ea3 l\u00e2m s\u00e0ng; \u0111\u1ed3ng th\u1eddi t\u00ecm ki\u1ebfm c\u00e1c d\u1ea5u \u1ea5n sinh h\u1ecdc m\u1edbi v\u1ec1 vi\u00eam v\u00e0 sinh l\u00fd \u0111\u1ec3 \u0111o l\u01b0\u1eddng hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb trong c\u00e1c th\u1eed nghi\u1ec7m t\u01b0\u01a1ng lai. <\/p>\n

Song song \u0111\u00f3, nh\u00f3m nghi\u00ean c\u1ee9u s\u1ebd s\u1eed d\u1ee5ng m\u00f4 h\u00ecnh th\u1ecf v\u00e0 chu\u1ed9t m\u1eafc lao m\u00e0ng n\u00e3o \u0111\u1ec3 x\u00e1c \u0111\u1ecbnh m\u1ee9c \u0111\u1ed9 d\u1ef1 b\u00e1o c\u1ee7a c\u00e1c nghi\u00ean c\u1ee9u tr\u00ean \u0111\u1ed9ng v\u1eadt \u0111\u1ed1i v\u1edbi ph\u1ea3n \u1ee9ng \u0111i\u1ec1u tr\u1ecb \u1edf ng\u01b0\u1eddi. C\u00e1c m\u00f4 h\u00ecnh n\u00e0y c\u0169ng \u0111\u01b0\u1ee3c d\u00f9ng \u0111\u1ec3 \u0111\u00e1nh gi\u00e1 ti\u1ec1m n\u0103ng c\u1ee7a ba lo\u1ea1i thu\u1ed1c m\u1edbi \u0111ang trong giai \u0111o\u1ea1n ph\u00e1t tri\u1ec3n l\u00e2m s\u00e0ng l\u00e0 ganfeborole (GSK<\/a>), telacebec (TB Alliance<\/a>) v\u00e0 TBAJ-876 (TB Alliance). <\/p>\n

\u0110\u1ed9i ng\u0169 h\u1ee3p t\u00e1c qu\u1ed1c t\u1ebf <\/h4>\n
\"\"<\/a>
\u0110\u1ed9i ng\u0169 nghi\u00ean c\u1ee9u \u0111\u1ebfn t\u1eeb Vi\u1ec7t Nam, Nam Phi, V\u01b0\u01a1ng qu\u00f4c Anh, Hoa K\u1ef3. B\u1ea3n \u0111\u1ed3: GS Guy Thwaites. <\/figcaption><\/figure>\n

D\u1ef1 \u00e1n \u0111\u01b0\u1ee3c \u0111i\u1ec1u ph\u1ed1i b\u1edfi Gi\u00e1o s\u01b0 Guy Thwaites, c\u00f9ng c\u00e1c c\u1ed9ng s\u1ef1: Sarah Walker<\/a> (\u0110\u1ea1i h\u1ecdc Oxford), Nguy\u1ec5n Th\u1ee5y Th\u01b0\u01a1ng Th\u01b0\u01a1ng<\/a> v\u00e0 Joseph Donovan<\/a> (OUCRU Vi\u1ec7t Nam), Martin Gengenbacher <\/a>(Trung t\u00e2m Kh\u00e1m ph\u00e1 v\u00e0 \u0110\u1ed5i m\u1edbi<\/a>, Hoa K\u1ef3), c\u00f9ng \u0111\u1ed9i ng\u0169 t\u1eeb \u0110\u1ea1i h\u1ecdc Cape Town<\/a> v\u00e0 CIDRI-Africa (Nam Phi) g\u1ed3m Robert Wilkinson<\/a>, Cari Stek<\/a>, Sean Wasserman<\/a> v\u00e0 Paolo Denti<\/a>. <\/p>\n

C\u00e1c \u0111\u1ed1i t\u00e1c tham gia bao g\u1ed3m GSK, TB Alliance, Medicines Development for Global Health<\/a>, v\u00e0 BioVersys<\/a>. <\/p>\n

T\u1ea7m nh\u00ecn d\u00e0i h\u1ea1n <\/h4>\n

Lao m\u00e0ng n\u00e3o g\u00e2y \u1ea3nh h\u01b0\u1edfng n\u1eb7ng n\u1ec1 nh\u1ea5t \u0111\u1ebfn ng\u01b0\u1eddi d\u00e2n t\u1ea1i c\u00e1c qu\u1ed1c gia c\u00f3 thu nh\u1eadp th\u1ea5p v\u00e0 trung b\u00ecnh. D\u00f9 c\u00e1c lo\u1ea1i thu\u1ed1c m\u1edbi \u0111ang d\u1ea7n xu\u1ea5t hi\u1ec7n, nh\u01b0ng n\u1ebfu thi\u1ebfu ki\u1ebfn th\u1ee9c \u0111\u1ec3 tri\u1ec3n khai ch\u00fang m\u1ed9t c\u00e1ch an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3, ti\u1ec1m n\u0103ng c\u1ee7a ch\u00fang s\u1ebd kh\u00f4ng th\u1ec3 \u0111\u01b0\u1ee3c khai th\u00e1c tr\u1ecdn v\u1eb9n. <\/p>\n

Nghi\u00ean c\u1ee9u n\u00e0y \u0111\u1eb7t m\u1ee5c ti\u00eau cung c\u1ea5p n\u1ec1n t\u1ea3ng tri th\u1ee9c \u0111\u00f3, t\u1eeb \u0111\u00f3 t\u1ea1o ti\u1ec1n \u0111\u1ec1 cho m\u1ed9t th\u1ebf h\u1ec7 th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng m\u1edbi, gi\u00fap gi\u1ea3m thi\u1ec3u \u0111\u00e1ng k\u1ec3 t\u1ec9 l\u1ec7 t\u1eed vong do c\u0103n b\u1ec7nh t\u00e0n kh\u1ed1c n\u00e0y g\u00e2y ra.<\/p>\n","protected":false},"excerpt":{"rendered":"

Ph\u00e1c \u0111\u1ed3 \u0111i\u1ec1u tr\u1ecb lao m\u00e0ng n\u00e3o v\u1ed1n kh\u00f4ng c\u00f3 thay \u0111\u1ed5i \u0111\u00e1ng k\u1ec3 n\u00e0o k\u1ec3 t\u1eeb nh\u1eefng n\u0103m 1950. M\u1ed9t ch\u01b0\u01a1ng tr\u00ecnh nghi\u00ean c\u1ee9u qu\u1ed1c t\u1ebf m\u1edbi do qu\u1ef9 Wellcome t\u00e0i tr\u1ee3 \u0111ang n\u1ed7 l\u1ef1c xoay chuy\u1ec3n th\u1ef1c tr\u1ea1ng n\u00e0y. <\/p>\n","protected":false},"author":39,"featured_media":55338,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":"","_wp_rev_ctl_limit":""},"categories":[291,229],"tags":[219],"class_list":["post-55281","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-oucru-ho-chi-minh","category-tin-tuc","tag-noi-bat"],"acf":[],"yoast_head":"\nOUCRU tri\u1ec3n khai ch\u01b0\u01a1ng tr\u00ecnh nghi\u00ean c\u1ee9u qu\u1ed1c t\u1ebf nh\u1eb1m t\u00ecm ki\u1ebfm chi\u1ebfn l\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb m\u1edbi cho lao m\u00e0ng n\u00e3o - OUCRU<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.oucru.org\/vi\/oucru-trien-khai-chuong-trinh-nghien-cuu-quoc-te-nham-tim-kiem-chien-luoc-dieu-tri-moi-cho-lao-mang-nao\/\" \/>\n<meta property=\"og:locale\" content=\"vi_VN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"OUCRU tri\u1ec3n khai ch\u01b0\u01a1ng tr\u00ecnh nghi\u00ean c\u1ee9u qu\u1ed1c t\u1ebf nh\u1eb1m t\u00ecm ki\u1ebfm chi\u1ebfn l\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb m\u1edbi cho lao m\u00e0ng n\u00e3o - OUCRU\" \/>\n<meta property=\"og:description\" content=\"Ph\u00e1c \u0111\u1ed3 \u0111i\u1ec1u tr\u1ecb lao m\u00e0ng n\u00e3o v\u1ed1n kh\u00f4ng c\u00f3 thay \u0111\u1ed5i \u0111\u00e1ng k\u1ec3 n\u00e0o k\u1ec3 t\u1eeb nh\u1eefng n\u0103m 1950. 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