{"id":9010,"date":"2021-10-20T15:28:10","date_gmt":"2021-10-20T08:28:10","guid":{"rendered":"https:\/\/www.oucru.vn\/nghien-cuu-toan-cau-ve-lao-lon-nhat-tu-truoc-den-nay-xac-dinh-nguyen-nhan-di-truyen-cua-tinh-khang-thuoc\/"},"modified":"2021-10-20T15:28:10","modified_gmt":"2021-10-20T08:28:10","slug":"nghien-cuu-toan-cau-ve-lao-lon-nhat-tu-truoc-den-nay-xac-dinh-nguyen-nhan-di-truyen-cua-tinh-khang-thuoc","status":"publish","type":"post","link":"https:\/\/www.oucru.org\/vi\/nghien-cuu-toan-cau-ve-lao-lon-nhat-tu-truoc-den-nay-xac-dinh-nguyen-nhan-di-truyen-cua-tinh-khang-thuoc\/","title":{"rendered":"Nghi\u00ean c\u1ee9u to\u00e0n c\u1ea7u v\u1ec1 lao l\u1edbn nh\u1ea5t t\u1eeb tr\u01b0\u1edbc \u0111\u1ebfn nay x\u00e1c \u0111\u1ecbnh nguy\u00ean nh\u00e2n di truy\u1ec1n c\u1ee7a t\u00ednh kh\u00e1ng thu\u1ed1c"},"content":{"rendered":"<p>C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u t\u1ea1i \u0110\u1ea1i h\u1ecdc Oxford \u0111\u00e3 s\u1eed d\u1ee5ng c\u00e1c k\u1ef9 thu\u1eadt gi\u1ea3i tr\u00ecnh t\u1ef1 gen ti\u00ean ti\u1ebfn \u0111\u1ec3 x\u00e1c \u0111\u1ecbnh h\u1ea7u h\u1ebft c\u00e1c bi\u1ebfn th\u1ec3 gen g\u00e2y ra t\u00ecnh tr\u1ea1ng kh\u00e1ng l\u1ea1i 13 lo\u1ea1i thu\u1ed1c ph\u1ed5 bi\u1ebfn nh\u1ea5t trong \u0111i\u1ec1u tr\u1ecb b\u1ec7nh lao.<\/p>\n<p>D\u1ef1 \u00e1n \u00a0\u201cD\u1ef1 b\u00e1o T\u00ednh kh\u00e1ng thu\u1ed1c To\u00e0n di\u1ec7n cho Hi\u1ec7p h\u1ed9i B\u1ec7nh Lao Qu\u1ed1c t\u1ebf (CRyPTIC)\u201d \u0111\u00e3 thu th\u1eadp b\u1ed9 d\u1eef li\u1ec7u c\u00e1c m\u1eabu vi khu\u1ea9n lao trong nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng l\u1edbn nh\u1ea5t t\u1eeb tr\u01b0\u1edbc \u0111\u1ebfn nay t\u1eeb kh\u1eafp n\u01a1i tr\u00ean th\u1ebf gi\u1edbi, g\u1ed3m 15.211 m\u1eabu t\u1eeb 27 qu\u1ed1c gia tr\u00ean n\u0103m ch\u00e2u l\u1ee5c.<\/p>\n<p>B\u1eb1ng c\u00e1ch s\u1eed d\u1ee5ng hai ti\u1ebfn b\u1ed9 quan tr\u1ecdng l\u00e0 x\u00e9t nghi\u1ec7m \u0111\u1ecbnh l\u01b0\u1ee3ng m\u1edbi v\u1ec1 t\u00ednh kh\u00e1ng thu\u1ed1c v\u00e0 c\u00e1ch ti\u1ebfp c\u1eadn m\u1edbi gi\u00fap x\u00e1c \u0111\u1ecbnh t\u1ea5t c\u1ea3 thay \u0111\u1ed5i v\u1ec1 di truy\u1ec1n trong m\u1eabu vi khu\u1ea9n lao kh\u00e1ng thu\u1ed1c, c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u \u0111\u00e3 t\u1ea1o ra b\u1ed9 d\u1eef li\u1ec7u \u0111\u1eb7c bi\u1ec7t \u0111\u1ec3 \u0111\u1ecbnh l\u01b0\u1ee3ng c\u00e1ch nh\u1eefng thay \u0111\u1ed5i trong m\u00e3 gen c\u1ee7a vi khu\u1ea9n lao l\u00e0m gi\u1ea3m kh\u1ea3 n\u0103ng ti\u00eau di\u1ec7t c\u00e1c vi khu\u1ea9n g\u00e2y b\u1ec7nh lao c\u1ee7a c\u00e1c lo\u1ea1i thu\u1ed1c kh\u00e1c nhau. C\u00f9ng v\u1edbi c\u00e1c c\u00f4ng tr\u00ecnh \u0111ang \u0111\u01b0\u1ee3c hi\u1ec7n trong l\u0129nh v\u1ef1c, nh\u1eefng \u0111\u1ed5i m\u1edbi n\u00e0y h\u1ee9a h\u1eb9n s\u1ebd mang l\u1ea1i c\u1ea3i thi\u1ec7n cho c\u00e1ch \u0111i\u1ec1u tr\u1ecb b\u1ec7nh lao trong t\u01b0\u01a1ng lai.<\/p>\n<p>B\u1ec7nh lao g\u00e2y t\u1eed vong \u1edf ng\u01b0\u1eddi cao h\u01a1n b\u1ea5t k\u1ef3 lo\u1ea1i vi khu\u1ea9n, vi-r\u00fat ho\u1eb7c k\u00fd sinh tr\u00f9ng n\u00e0o kh\u00e1c g\u00e2y ra, ngo\u1ea1i tr\u1eeb SARS-CoV-2. M\u1eb7c d\u00f9 b\u1ec7nh c\u00f3 th\u1ec3 \u0111i\u1ec1u tr\u1ecb \u0111\u01b0\u1ee3c, t\u00ednh kh\u00e1ng thu\u1ed1c \u0111\u00e3 tr\u1edf th\u00e0nh m\u1ed9t v\u1ea5n \u0111\u1ec1 l\u1edbn trong su\u1ed1t ba th\u1eadp k\u1ef7 qua. Vi\u1ec7c x\u00e1c \u0111\u1ecbnh c\u00e1c \u0111\u1ed9t bi\u1ebfn trong b\u1ed9 gen c\u1ee7a vi khu\u1ea9n lao \u0111\u1ec3 x\u00e1c \u0111\u1ecbnh lo\u1ea1i thu\u1ed1c n\u00e0o s\u1ebd mang l\u1ea1i c\u01a1 h\u1ed9i ch\u1eefa kh\u1ecfi t\u1ed1t nh\u1ea5t cho b\u1ec7nh nh\u00e2n l\u00e0 c\u00e1ch th\u1ef1c t\u1ebf nh\u1ea5t \u0111\u1ec3 ki\u1ec3m tra t\u00ednh kh\u00e1ng thu\u1ed1c cho b\u1ec7nh nh\u00e2n.<\/p>\n<p>Ti\u1ebfn s\u0129 Timothy Walker, l\u00e0 Wellcome Fellow t\u1ea1i \u0110\u01a1n v\u1ecb Nghi\u00ean c\u1ee9u L\u00e2m s\u00e0ng \u0110\u1ea1i h\u1ecdc Oxford (OUCRU) \u0111\u1ed3ng th\u1eddi c\u0169ng l\u00e0 \u00a0Ph\u00f3 Gi\u00e1o s\u01b0 t\u1ea1i \u0110\u1ea1i h\u1ecdc Oxford, cho bi\u1ebft: \u201cD\u1ef1 \u00e1n n\u00e0y l\u00e0 c\u00f4ng tr\u00ecnh qu\u1ed1c t\u1ebf l\u1edbn \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n trong h\u01a1n 5 n\u0103m qua v\u00e0 s\u1ebd mang l\u1ea1i l\u1ee3i \u00edch cho b\u1ec7nh nh\u00e2n v\u00e0 c\u1ed9ng \u0111\u1ed3ng khi d\u1eef li\u1ec7u \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 ch\u1ea9n \u0111o\u00e1n v\u00e0 qu\u1ea3n l\u00fd lao kh\u00e1ng thu\u1ed1c m\u1ed9t c\u00e1ch hi\u1ec7u qu\u1ea3 v\u00e0 l\u00e0m gi\u1ea3m s\u1ef1 l\u00e2y truy\u1ec1n\u201d.<\/p>\n<p>Trong ch\u00edn b\u1ea3n th\u1ea3o m\u1edbi ch\u01b0a \u0111\u01b0\u1ee3c b\u00ecnh duy\u1ec7t, v\u1edbi m\u1ed7i b\u1ea3n ghi l\u1ea1i m\u1ed9t kh\u00eda c\u1ea1nh ti\u1ebfn b\u1ed9 kh\u00e1c nhau m\u00e0 d\u1ef1 \u00e1n CRyPTIC \u0111\u00e3 mang l\u1ea1i cho l\u0129nh v\u1ef1c, c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u tr\u00ecnh b\u00e0y v\u1ec1:<\/p>\n<ul>\n<li>C\u00e1ch di\u1ec5n gi\u1ea3i c\u00e1c x\u00e9t nghi\u1ec7m kh\u00e1ng thu\u1ed1c m\u1edbi [1] v\u00e0 c\u00e1ch m\u1ed9t d\u1ef1 \u00e1n khoa h\u1ecdc c\u1ed9ng \u0111\u1ed3ng v\u1edbi s\u1ed1 m\u1eabu l\u1edbn \u0111\u00e3 gi\u00fap gi\u1ea3i quy\u1ebft v\u1ea5n \u0111\u1ec1 n\u00e0y [2]<\/li>\n<li>C\u00e1ch ti\u1ebfp c\u1eadn m\u1edbi v\u1ec1 ph\u00e1t hi\u1ec7n v\u00e0 m\u00f4 t\u1ea3 nh\u1eefng thay \u0111\u1ed5i di truy\u1ec1n trong to\u00e0n b\u1ed9 tr\u00ecnh t\u1ef1 gen c\u1ee7a lao \u0111\u00e3 c\u1ea3i thi\u1ec7n c\u00e1ch th\u1ee9c ph\u00e1t hi\u1ec7n nh\u1eefng thay \u0111\u1ed5i di truy\u1ec1n d\u1eabn \u0111\u1ebfn t\u00ecnh tr\u1ea1ng kh\u00e1ng thu\u1ed1c nh\u01b0 th\u1ebf n\u00e0o [3]<\/li>\n<li>C\u00e1ch s\u1eed d\u1ee5ng nh\u1eefng d\u1eef li\u1ec7u n\u00e0y \u0111\u1ec3 qu\u00e9t tr\u00ecnh t\u1ef1 b\u1ed9 gen lao \u0111\u1ec3 t\u00ecm nh\u1eefng thay \u0111\u1ed5i l\u00e0 nguy\u00ean nh\u00e2n g\u00e2y ra kh\u00e1ng thu\u1ed1c m\u00e0 tr\u01b0\u1edbc \u0111\u00e2y ch\u01b0a \u0111\u01b0\u1ee3c bi\u1ebft \u0111\u1ebfn [4]<\/li>\n<li>C\u00e1ch c\u00e1c \u0111\u1ed9t bi\u1ebfn \u0111\u01a1n v\u00e0 t\u1ed5 h\u1ee3p c\u00e1c \u0111\u1ed9t bi\u1ebfn c\u00f3 th\u1ec3 li\u00ean quan kh\u00f4ng ch\u1ec9 \u0111\u1ebfn vi\u1ec7c x\u00e1c \u0111\u1ecbnh t\u00ednh \u2018kh\u00e1ng thu\u1ed1c\u2019 ho\u1eb7c t\u00ednh \u2018nh\u1ea1y thu\u1ed1c\u2019, m\u00e0 c\u00f2n \u0111\u1ebfn nh\u1eefng thay \u0111\u1ed5i nh\u1ecf trong c\u00e1ch kh\u00e1ng sinh ti\u00eau di\u1ec7t vi khu\u1ea9n lao, t\u1eeb \u0111\u00f3 l\u00e0m gi\u1ea3m hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb [5], \u0111\u1eb7c bi\u1ec7t \u00a0l\u00e0 hai lo\u1ea1i kh\u00e1ng sinh m\u1edbi \u0111ang \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb b\u1ec7nh lao [6]<\/li>\n<li>C\u00e1ch c\u00e1c thu\u1eadt to\u00e1n tr\u00ed tu\u1ec7 nh\u00e2n t\u1ea1o c\u00f3 th\u1ec3 d\u1ef1 \u0111o\u00e1n t\u00ednh kh\u00e1ng thu\u1ed1c t\u1eeb c\u00e1c d\u1ea5u hi\u1ec7u trong b\u1ed9 gen vi khu\u1ea9n lao [7]<\/li>\n<li>C\u00e1ch nh\u1eefng d\u1eef li\u1ec7u n\u00e0y [8] \u0111\u00e3 g\u00f3p ph\u1ea7n v\u00e0o danh s\u00e1ch \u0111\u1ed9t bi\u1ebfn kh\u00e1ng thu\u1ed1c tr\u00ean b\u1ed9 gen vi khu\u1ea9n lao \u0111\u1ea7u ti\u00ean \u0111\u01b0\u1ee3c T\u1ed5 ch\u1ee9c Y t\u1ebf Th\u1ebf gi\u1edbi c\u00f4ng nh\u1eadn cho s\u1eed d\u1ee5ng tr\u00ean to\u00e0n c\u1ea7u [9].<\/li>\n<\/ul>\n<p>K\u1ebft qu\u1ea3 c\u1ee7a nghi\u00ean c\u1ee9u nh\u1eb1m m\u1ee5c \u0111\u00edch c\u1ea3i thi\u1ec7n vi\u1ec7c ki\u1ec3m so\u00e1t b\u1ec7nh lao v\u00e0 t\u1ea1o \u0111i\u1ec1u ki\u1ec7n cho vi\u1ec7c th\u1ef1c hi\u1ec7n chi\u1ebfn l\u01b0\u1ee3c ch\u1ea5m d\u1ee9t b\u1ec7nh lao c\u1ee7a T\u1ed5 ch\u1ee9c Y t\u1ebf Th\u1ebf gi\u1edbi, th\u00f4ng qua \u0111i\u1ec1u tr\u1ecb lao kh\u00e1ng thu\u1ed1c t\u1ed1t h\u01a1n, nhanh h\u01a1n v\u00e0 c\u00f3 m\u1ee5c ti\u00eau h\u01a1n b\u1eb1ng d\u1ef1 b\u00e1o t\u00ednh kh\u00e1ng thu\u1ed1c b\u1eb1ng ki\u1ec3u di truy\u1ec1n, m\u1edf \u0111\u01b0\u1eddng cho vi\u1ec7c x\u00e9t nghi\u1ec7m t\u00ednh nh\u1ea1y \u00a0thu\u1ed1c tr\u00ean to\u00e0n c\u1ea7u.<\/p>\n<p>\u201cNh\u1eefng c\u00f4ng tr\u00ecnh h\u1ee3p t\u00e1c qu\u1ed1c t\u1ebf \u0111ang \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n nh\u01b0 nghi\u00ean c\u1ee9u n\u00e0y l\u00e0 r\u1ea5t c\u1ea7n thi\u1ebft trong vi\u1ec7c th\u00fac \u0111\u1ea9y hi\u1ec3u bi\u1ebft v\u1ec1 c\u00e1c b\u1ec7nh truy\u1ec1n nhi\u1ec5m v\u00e0 c\u00e1ch \u0111i\u1ec1u tr\u1ecb ch\u00fang. Nh\u1eefng ti\u1ebfn b\u1ed9 n\u00e0y mang l\u1ea1i l\u1ee3i \u00edch cho t\u1ea5t c\u1ea3 m\u1ecdi ng\u01b0\u1eddi, nh\u01b0 ch\u00fang ta \u0111\u00e3 bi\u1ebft t\u1eeb kinh nghi\u1ec7m v\u1edbi COVID-19\u201d, Ti\u1ebfn s\u0129 Walker nh\u1ea5n m\u1ea1nh.<\/p>\n<p>D\u1eef li\u1ec7u hi\u1ec7n \u0111\u01b0\u1ee3c cung c\u1ea5p mi\u1ec5n ph\u00ed, v\u00e0 c\u1ed9ng \u0111\u1ed3ng khoa h\u1ecdc c\u00f3 th\u1ec3 s\u1eed d\u1ee5ng d\u1eef li\u1ec7u \u0111\u1ec3 n\u00e2ng cao hi\u1ec3u bi\u1ebft v\u1ec1 t\u00ecnh tr\u1ea1ng kh\u00e1ng thu\u1ed1c \u1edf b\u1ec7nh lao v\u00e0 c\u00e1ch \u0111i\u1ec1u tr\u1ecb t\u1ed1t nh\u1ea5t cho c\u0103n b\u1ec7nh n\u00e0y.<\/p>\n<p>D\u1ef1 \u00e1n \u0111\u01b0\u1ee3c t\u00e0i tr\u1ee3 b\u1edfi Qu\u1ef9 MRC Newton, Wellcome, v\u00e0 Qu\u1ef9 Bill &amp; Melinda Gates. \u0110\u1ed9i ng\u0169 c\u00e1c nh\u00e0 khoa h\u1ecdc d\u1eabn d\u1eaft b\u1edfi Ti\u1ebfn s\u0129 Walker hi\u1ec7n \u0111ang l\u00e0m vi\u1ec7c t\u1ea1i Th\u00e0nh ph\u1ed1 H\u1ed3 Ch\u00ed Minh, Vi\u1ec7t Nam t\u1ea1i \u0110\u01a1n v\u1ecb Nghi\u00ean c\u1ee9u L\u00e2m s\u00e0ng \u0110\u1ea1i h\u1ecdc Oxford (OUCRU), m\u1ed9t trong n\u0103m Ch\u01b0\u01a1ng tr\u00ecnh Ch\u00e2u \u00c1-Ch\u00e2u Phi c\u1ee7a Qu\u1ef9 Wellcome.<\/p>\n<p>\u0110\u1ec3 bi\u1ebft th\u00eam th\u00f4ng tin, vui l\u00f2ng li\u00ean h\u1ec7 v\u1edbi Nh\u00f3m Truy\u1ec1n th\u00f4ng c\u1ee7a \u0110\u01a1n v\u1ecb Nghi\u00ean c\u1ee9u L\u00e2m s\u00e0ng \u0110\u1ea1i h\u1ecdc Oxford (OUCRU) theo \u0111\u1ecba ch\u1ec9 <a href=\"mailto:communications@oucru.org\">communications@oucru.org<\/a>.<\/p>\n<p>C\u00e1c b\u1ea3n th\u1ea3o:<\/p>\n<ol>\n<li>Epidemiological cutoff values for a 96-well broth microdilution plate for high-throughput research antibiotic susceptibility testing of\u00a0<em> tuberculosis<\/em>. The CRyPTIC Consortium (2021) medRxiv preprint. <a href=\"https:\/\/doi.org\/10.1101\/2021.02.24.21252386\">https:\/\/doi.org\/10.1101\/2021.02.24.21252386<\/a><\/li>\n<li>BashTheBug: a crowd of volunteers reproducibly and accurately measure the minimum inhibitory concentrations of 13 antitubercular drugs from photographs of 96-well broth microdilution plates. Fowler PW et al. (2021) biorXiv preprint. <a href=\"https:\/\/doi.org\/10.1101\/2021.07.20.453060\">https:\/\/doi.org\/10.1101\/2021.07.20.453060<\/a><\/li>\n<li>Minos: variant adjudication and joint genotyping of cohorts of bacterial genomes. Hunt M et al. (2021). bioRxiv preprint. <a href=\"https:\/\/doi.org\/10.1101\/2021.09.15.460475\">https:\/\/doi.org\/10.1101\/2021.09.15.460475<\/a><\/li>\n<li>Genome-wide association studies of global <em>Mycobacterium tuberculosis <\/em>resistance to thirteen antimicrobials in 10,228 genomes. The CRyPTIC Consortium (2021). bioRxiv preprint. <a href=\"https:\/\/doi.org\/10.1101\/2021.09.14.460272\">https:\/\/doi.org\/10.1101\/2021.09.14.460272<\/a><\/li>\n<li>Quantitative measurement of antibiotic resistance in <em> tuberculosis<\/em> reveals genetic determinants of resistance and susceptibility in a target gene approach. The CRyPTIC Consortium (2021). bioRxiv preprint. <a href=\"https:\/\/doi.org\/10.1101\/2021.09.14.460353\">https:\/\/doi.org\/10.1101\/2021.09.14.460353<\/a><\/li>\n<li>Deciphering Bedaquiline and Clofazimine Resistance in Tuberculosis: An Evolutionary Medicine Approach. Sonnenkalb L et al. (2021) biorXiv preprint. <a href=\"https:\/\/doi.org\/10.1101\/2021.03.19.436148\">https:\/\/doi.org\/10.1101\/2021.03.19.436148<\/a><\/li>\n<li>A generalisable approach to drug susceptibility prediction for <em> tuberculosis<\/em> using machine learning and whole-genome sequencing. The CRyPTIC Consortium (2021). bioRxiv preprint. <a href=\"https:\/\/doi.org\/10.1101\/2021.09.14.458035\">https:\/\/doi.org\/10.1101\/2021.09.14.458035<\/a><\/li>\n<li>A data compendium of <em>Mycobacterium tuberculosis<\/em> antibiotic resistance. The CRyPTIC Consortium (2021) bioRxiv preprint. <a href=\"https:\/\/doi.org\/10.1101\/2021.09.14.460274\">https:\/\/doi.org\/10.1101\/2021.09.14.460274<\/a><\/li>\n<li>The 2021 WHO catalogue of <em> tuberculosis<\/em> complex mutations associated with drug resistance: A new global standard for molecular diagnostics. Walker et al. (2021) Lancet preprint.<a href=\"https:\/\/papers.ssrn.com\/sol3\/papers.cfm?abstract_id=3923444\">https:\/\/papers.ssrn.com\/sol3\/papers.cfm?abstract_id=3923444<\/a> <a href=\"http:\/\/www.crypticproject.org\/wp-content\/uploads\/2021\/09\/CRyPTIC9-WHO-preprint.pdf\">http:\/\/www.crypticproject.org\/wp-content\/uploads\/2021\/09\/CRyPTIC9-WHO-preprint.pdf<\/a><\/li>\n<\/ol>\n<p>Vui l\u00f2ng l\u01b0u \u00fd r\u1eb1ng nh\u1eefng b\u1ea3n th\u1ea3o n\u00e0y l\u00e0 b\u1ea3n ch\u01b0a \u0111\u01b0\u1ee3c b\u00ecnh duy\u1ec7t (preprint).<\/p>\n","protected":false},"excerpt":{"rendered":"<p>C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u t\u1ea1i \u0110\u1ea1i h\u1ecdc Oxford \u0111\u00e3 s\u1eed d\u1ee5ng c\u00e1c k\u1ef9 thu\u1eadt gi\u1ea3i tr\u00ecnh t\u1ef1 gen ti\u00ean ti\u1ebfn \u0111\u1ec3 x\u00e1c \u0111\u1ecbnh h\u1ea7u h\u1ebft c\u00e1c bi\u1ebfn th\u1ec3 gen g\u00e2y [&hellip;]<\/p>\n","protected":false},"author":28,"featured_media":9780,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":"","_wp_rev_ctl_limit":""},"categories":[229],"tags":[],"class_list":["post-9010","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-tin-tuc"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.3.1 - 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