{"id":9046,"date":"2022-05-18T14:29:14","date_gmt":"2022-05-18T07:29:14","guid":{"rendered":"https:\/\/www.oucru.vn\/nghien-cuu-dau-tien-chung-minh-thuoc-khang-doc-to-ngua-an-toan-va-hieu-qua-trong-viec-dieu-tri-uon-van-o-nguoi-lon\/"},"modified":"2022-05-18T14:29:14","modified_gmt":"2022-05-18T07:29:14","slug":"nghien-cuu-dau-tien-chung-minh-thuoc-khang-doc-to-ngua-an-toan-va-hieu-qua-trong-viec-dieu-tri-uon-van-o-nguoi-lon","status":"publish","type":"post","link":"https:\/\/www.oucru.org\/vi\/nghien-cuu-dau-tien-chung-minh-thuoc-khang-doc-to-ngua-an-toan-va-hieu-qua-trong-viec-dieu-tri-uon-van-o-nguoi-lon\/","title":{"rendered":"Nghi\u00ean c\u1ee9u \u0111\u1ea7u ti\u00ean ch\u1ee9ng minh thu\u1ed1c kh\u00e1ng \u0111\u1ed9c t\u1ed1 ng\u1ef1a an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3 trong vi\u1ec7c \u0111i\u1ec1u tr\u1ecb u\u1ed1n v\u00e1n \u1edf ng\u01b0\u1eddi l\u1edbn"},"content":{"rendered":"

L\u1ea7n \u0111\u1ea7u ti\u00ean, m\u1ed9t th\u1eed nghi\u1ec7m \u0111\u1ed1i ch\u1ee9ng ng\u1eabu nhi\u00ean \u0111\u00e3 so s\u00e1nh hai ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb kh\u00e1ng \u0111\u1ed9c t\u1ed1 kh\u00e1c nhau cho b\u1ec7nh u\u1ed1n v\u00e1n. Khi so s\u00e1nh t\u00e1c d\u1ee5ng c\u1ee7a kh\u00e1ng \u0111\u1ed9c t\u1ed1 ng\u01b0\u1eddi v\u00e0 ng\u1ef1a, v\u1edbi ph\u01b0\u01a1ng ph\u00e1p ti\u00eam b\u1eafp, kh\u00e1ng \u0111\u1ed9c t\u1ed1 ng\u1ef1a \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh l\u00e0 an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3 trong vi\u1ec7c \u0111i\u1ec1u tr\u1ecb u\u1ed1n v\u00e1n \u1edf ng\u01b0\u1eddi l\u1edbn. Nghi\u00ean c\u1ee9u c\u0169ng x\u00e1c \u0111\u1ecbnh vi\u1ec7c b\u1ed5 sung kh\u00e1ng \u0111\u1ed9c t\u1ed1 n\u1ed9i t\u1ee7y (t\u1ee7y s\u1ed1ng) kh\u00f4ng mang l\u1ea1i th\u00eam l\u1ee3i \u00edch n\u00e0o so v\u1edbi \u0111i\u1ec1u tr\u1ecb b\u1eb1ng kh\u00e1ng \u0111\u1ed9c t\u1ed1 ti\u00eam b\u1eafp \u0111\u01a1n thu\u1ea7n.<\/p>\n

\u0110\u1ed3ng th\u1ef1c hi\u1ec7n b\u1edfi \u0110\u01a1n v\u1ecb Nghi\u00ean c\u1ee9u L\u00e2m s\u00e0ng \u0110\u1ea1i h\u1ecdc Oxford<\/a> (OUCRU) v\u00e0 B\u1ec7nh vi\u1ec7n B\u1ec7nh Nhi\u1ec7t \u0111\u1edbi Th\u00e0nh ph\u1ed1 H\u1ed3 Ch\u00ed Minh<\/a>, nghi\u00ean c\u1ee9u n\u00e0y c\u00f3 \u00fd ngh\u0129a quan tr\u1ecdng trong vi\u1ec7c \u0111i\u1ec1u tr\u1ecb u\u1ed1n v\u00e1n, \u0111\u1eb7c bi\u1ec7t \u1edf nh\u1eefng \u0111\u1ecba ph\u01b0\u01a1ng ch\u01b0a c\u00f3 ngu\u1ed3n l\u1ef1c.<\/p>\n

C\u00e1c k\u1ebft qu\u1ea3 c\u1ee7a nghi\u00ean c\u1ee9u khuy\u1ebfn ngh\u1ecb d\u00f9ng kh\u00e1ng \u0111\u1ed9c t\u1ed1 ti\u00eam b\u1eafp cho \u0111i\u1ec1u tr\u1ecb u\u1ed1n v\u00e1n. Nghi\u00ean c\u1ee9u kh\u00f4ng t\u00ecm th\u1ea5y b\u1eb1ng ch\u1ee9ng n\u00e0o cho th\u1ea5y kh\u00e1ng \u0111\u1ed9c t\u1ed1 ng\u1ef1a c\u00f3 t\u00e1c d\u1ee5ng ph\u1ee5 nhi\u1ec1u so v\u1edbi kh\u00e1ng \u0111\u1ed9c t\u1ed1 ng\u01b0\u1eddi.<\/p>\n

So v\u1edbi kh\u00e1ng \u0111\u1ed9c t\u1ed1 ng\u01b0\u1eddi, kh\u00e1ng \u0111\u1ed9c t\u1ed1 ng\u1ef1a r\u1ebb h\u01a1n v\u00e0 s\u1eb5n c\u00f3 h\u01a1n \u1edf nhi\u1ec1u n\u01b0\u1edbc. Nghi\u00ean c\u1ee9u ph\u00e1t hi\u1ec7n kh\u00e1ng \u0111\u1ed9c t\u1ed1 ng\u1ef1a l\u00e0 an to\u00e0n, \u0111\u1eb7c bi\u1ec7t \u1edf nh\u1eefng n\u01a1i kh\u00f4ng c\u00f3 kh\u00e1ng \u0111\u1ed9c t\u1ed1 ng\u01b0\u1eddi.<\/p>\n

\u0110\u1ed9c t\u1ed1 u\u1ed1n v\u00e1n ho\u1ea1t \u0111\u1ed9ng trong h\u1ec7 th\u1ed1ng th\u1ea7n kinh trung \u01b0\u01a1ng, n\u01a1i kh\u00e1ng \u0111\u1ed9c t\u1ed1 ti\u00eam ngo\u1ea1i vi \u00edt x\u00e2m nh\u1eadp v\u00e0o \u0111\u01b0\u1ee3c; do \u0111\u00f3, ti\u00eam kh\u00e1ng \u0111\u1ed9c t\u1ed1 n\u1ed9i t\u1ee7y (v\u00e0o t\u1ee7y s\u1ed1ng) tr\u01b0\u1edbc \u0111\u00f3 \u0111\u00e3 \u0111\u01b0\u1ee3c tin r\u1eb1ng s\u1ebd gi\u00fap c\u1ea3i thi\u1ec7n k\u1ebft qu\u1ea3 l\u00e2m s\u00e0ng so v\u1edbi ti\u00eam b\u1eafp. Nghi\u00ean c\u1ee9u n\u00e0y cho th\u1ea5y r\u1eb1ng ti\u00eam n\u1ed9i t\u1ee7y \u2013 m\u1ed9t th\u1ee7 thu\u1eadt x\u00e2m l\u1ea5n \u2013 kh\u00f4ng l\u00e0m gi\u1ea3m \u0111\u00e1ng k\u1ec3 nhu c\u1ea7u th\u1edf m\u00e1y \u1edf ng\u01b0\u1eddi l\u1edbn m\u1eafc u\u1ed1n v\u00e1n.<\/p>\n

BS. L\u00e2m Minh Y\u1ebfn, B\u00e1c s\u0129 Nghi\u00ean c\u1ee9u C\u1ea5p cao t\u1ea1i OUCRU, v\u00e0 TS. BS. Nguy\u1ec5n V\u0103n H\u1ea3o, T\u00e1c gi\u1ea3 th\u1ee9 nh\u1ea5t, Tr\u01b0\u1edfng Khoa H\u1ed3i s\u1ee9c C\u1ea5p c\u1ee9u Ch\u1ed1ng \u0111\u1ed9c Ng\u01b0\u1eddi l\u1edbn c\u1ee7a B\u1ec7nh vi\u1ec7n B\u1ec7nh Nhi\u1ec7t \u0111\u1edbi TP.HCM v\u00e0 Tr\u01b0\u1edfng B\u1ed9 m\u00f4n Nhi\u1ec5m \u2013 \u0110\u1ea1i h\u1ecdc Y D\u01b0\u1ee3c TP.HCM, cho bi\u1ebft: \u201cK\u1ebft qu\u1ea3 c\u1ee7a nghi\u00ean c\u1ee9u kh\u1eb3ng \u0111\u1ecbnh r\u1eb1ng ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb u\u1ed1n v\u00e1n b\u1eb1ng kh\u00e1ng \u0111\u1ed9c t\u1ed1 ng\u1ef1a ti\u00eam b\u1eafp \u2013 m\u1ed9t ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb x\u00e2m l\u1ea5n t\u1ed1i thi\u1ec3u \u2013 l\u00e0 an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3. So v\u1edbi ph\u01b0\u01a1ng ph\u00e1p ti\u00eam n\u1ed9i t\u1ee7y ph\u1ee9c t\u1ea1p v\u00e0 x\u00e2m l\u1ea5n, nghi\u00ean c\u1ee9u cho th\u1ea5y ti\u1ec1m n\u0103ng s\u1eed d\u1ee5ng kh\u00e1ng \u0111\u1ed9c t\u1ed1 ng\u1ef1a ti\u00eam b\u1eafp, \u0111\u1eb7c bi\u1ec7t l\u00e0 \u1edf nh\u1eefng qu\u1ed1c gia c\u00f3 thu nh\u1eadp th\u1ea5p v\u00e0 trung b\u00ecnh\u201d.<\/p>\n

K\u00e9o d\u00e0i trong 3 n\u0103m, nghi\u00ean c\u1ee9u \u0111\u00e3 thu tuy\u1ec3n 272 b\u1ec7nh nh\u00e2n ng\u01b0\u1eddi l\u1edbn nh\u1eadp vi\u1ec7n \u1edf Khoa H\u1ed3i s\u1ee9c C\u1ea5p c\u1ee9u c\u1ee7a B\u1ec7nh vi\u1ec7n B\u1ec7nh nhi\u1ec7t \u0111\u1edbi \u0111\u01b0\u1ee3c ch\u1ea9n \u0111o\u00e1n m\u1eafc u\u1ed1n v\u00e1n to\u00e0n th\u00e2n.<\/p>\n

PGS. TS. Louise Thwaites, Nghi\u00ean c\u1ee9u vi\u00ean L\u00e2m s\u00e0ng C\u1ea5p cao t\u1ea1i OUCRU v\u00e0 Ph\u00f3 Gi\u00e1o s\u01b0 t\u1ea1i Trung t\u00e2m Y h\u1ecdc Nhi\u1ec7t \u0111\u1edbi v\u00e0 S\u1ee9c kh\u1ecfe To\u00e0n c\u1ea7u<\/a> \u2013 \u0110\u1ea1i h\u1ecdc Oxford<\/a>, chia s\u1ebb: \u201cT\u00f4i ngh\u0129 OUCRU v\u00e0 B\u1ec7nh vi\u1ec7n B\u1ec7nh nhi\u1ec7t \u0111\u1edbi c\u00f3 kh\u1ea3 n\u0103ng \u0111\u1eb7c bi\u1ec7t \u0111\u1ec3 th\u1ef1c hi\u1ec7n nh\u1eefng th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng l\u1edbn v\u1ec1 u\u1ed1n v\u00e1n nh\u01b0 nghi\u00ean c\u1ee9u n\u00e0y. Nghi\u00ean c\u1ee9u k\u1ebft h\u1ee3p c\u1ea3 chuy\u00ean m\u00f4n v\u1ec1 th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng l\u1eabn chuy\u00ean m\u00f4n l\u00e2m s\u00e0ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb cho b\u1ec7nh nh\u00e2n u\u1ed1n v\u00e1n, v\u00e0 ch\u00fang t\u00f4i hy v\u1ecdng h\u1ecd ch\u00ednh l\u00e0 \u0111\u1ed1i t\u01b0\u1ee3ng h\u01b0\u1edfng l\u1ee3i t\u1eeb nh\u1eefng nghi\u00ean c\u1ee9u nh\u01b0 th\u1ebf n\u00e0y\u201d.<\/p>\n

\u201cNghi\u00ean c\u1ee9u n\u00e0y r\u1ea5t quan tr\u1ecdng, v\u00ec n\u00f3 l\u00e0 m\u1ed9t trong s\u1ed1 \u00edt c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng v\u1ec1 m\u1ed9t c\u0103n b\u1ec7nh v\u1eabn \u0111ang \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn nhi\u1ec1u ng\u01b0\u1eddi \u1edf c\u00e1c qu\u1ed1c gia thu nh\u1eadp th\u1ea5p v\u00e0 trung b\u00ecnh m\u1ed7i n\u0103m. Th\u1eed nghi\u1ec7m cho th\u1ea5y vi\u1ec7c ti\u00eam kh\u00e1ng \u0111\u1ed9c t\u1ed1 (ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb ch\u00ednh cho u\u1ed1n v\u00e1n) b\u1eb1ng \u0111\u01b0\u1eddng t\u1ee7y s\u1ed1ng kh\u00f4ng c\u1ea3i thi\u1ec7n \u0111\u00e1ng k\u1ec3 m\u1ee9c \u0111\u1ed9 nghi\u00eam tr\u1ecdng hay k\u1ebft c\u1ee5c c\u1ee7a b\u1ec7nh, so v\u1edbi \u0111\u01b0\u1eddng th\u00f4ng th\u01b0\u1eddng (v\u00e0o c\u01a1)\u201d.<\/p>\n

PGS. TS. Louise Thwaites k\u1ebft lu\u1eadn: \u201cK\u1ebft qu\u1ea3 c\u1ee7a nghi\u00ean c\u1ee9u r\u1ea5t h\u1eefu \u00edch cho c\u00e1c b\u00e1c s\u0129 \u0111i\u1ec1u tr\u1ecb u\u1ed1n v\u00e1n tr\u00ean to\u00e0n th\u1ebf gi\u1edbi, \u0111\u1eb7c bi\u1ec7t l\u00e0 \u1edf nh\u1eefng n\u01a1i c\u00f3 ngu\u1ed3n l\u1ef1c h\u1ea1n ch\u1ebf, v\u00e0 cho th\u1ea5y r\u1eb1ng nh\u1eefng ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb ph\u1ee9c t\u1ea1p v\u00e0 t\u01b0\u01a1ng \u0111\u1ed1i t\u1ed1n k\u00e9m l\u00e0 kh\u00f4ng c\u1ea7n thi\u1ebft trong vi\u1ec7c \u0111i\u1ec1u tr\u1ecb u\u1ed1n v\u00e1n\u201d.<\/p>\n

\n

Th\u00f4ng tin li\u00ean h\u1ec7: <\/strong>communications@oucru.org<\/a><\/p>\n

Tr\u00edch d\u1eabn: <\/strong>N Van Hao PhD, H Thi Loan MD et al. Human versus equine intramuscular antitoxin, with or without human intrathecal antitoxin, for the treatment of adults with tetanus: a 2\u2008\u00d7\u20082 factorial randomised controlled trial. The Lancet Global Health 2022;10(6):e862-e872. Available from: https:\/\/www.thelancet.com\/journals\/langlo\/article\/PIIS2214-109X(22)00117-6\/fulltext<\/a><\/p>\n

\u00a0<\/strong>*Ch\u01b0\u01a1ng tr\u00ecnh t\u1eadp hu\u1ea5n trong h\u00ecnh \u1ea3nh l\u00e0 m\u1ed9t ph\u1ea7n c\u1ee7a d\u1ef1 \u00e1n c\u00f3 ti\u00eau \u0111\u1ec1: ‘T\u00ednh kh\u1ea3 thi v\u00e0 kh\u1ea3 n\u0103ng ch\u1ea5p nh\u1eadn c\u1ee7a ch\u01b0\u01a1ng tr\u00ecnh ph\u1ee5c h\u1ed3i ch\u1ee9c n\u0103ng do gia \u0111\u00ecnh th\u1ef1c hi\u1ec7n cho b\u1ec7nh nh\u00e2n u\u1ed1n v\u00e1n’, nh\u1eb1m m\u1ee5c \u0111\u00edch thi\u1ebft k\u1ebf quan h\u1ec7 \u0111\u1ed1i t\u00e1c gi\u1eefa nh\u00e2n vi\u00ean y t\u1ebf & ng\u01b0\u1eddi ch\u0103m s\u00f3c trong gia \u0111\u00ecnh b\u1ec7nh nh\u00e2n \u0111\u1ec3 cung c\u1ea5p m\u1ed9t ch\u01b0\u01a1ng tr\u00ecnh ph\u1ee5c h\u1ed3i ch\u1ee9c n\u0103ng cho b\u1ec7nh nh\u00e2n u\u1ed1n v\u00e1n, sau \u0111\u00f3 \u0111\u00e1nh gi\u00e1 t\u00ednh kh\u1ea3 thi, t\u00ednh b\u1ec1n v\u1eefng v\u00e0 kh\u1ea3 n\u0103ng \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn c\u1ee7a c\u00e1ch ti\u1ebfp c\u1eadn n\u00e0y.<\/p>\n

Ngu\u1ed3n t\u00e0i tr\u1ee3: <\/strong>Qu\u1ef9 Wellcome<\/p>\n","protected":false},"excerpt":{"rendered":"

L\u1ea7n \u0111\u1ea7u ti\u00ean, m\u1ed9t th\u1eed nghi\u1ec7m \u0111\u1ed1i ch\u1ee9ng ng\u1eabu nhi\u00ean \u0111\u00e3 so s\u00e1nh hai ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb kh\u00e1ng \u0111\u1ed9c t\u1ed1 kh\u00e1c nhau cho b\u1ec7nh u\u1ed1n v\u00e1n. Khi so s\u00e1nh […]<\/p>\n","protected":false},"author":28,"featured_media":9811,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":"","_wp_rev_ctl_limit":""},"categories":[229],"tags":[],"class_list":["post-9046","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-tin-tuc"],"acf":[],"yoast_head":"\nNghi\u00ean c\u1ee9u \u0111\u1ea7u ti\u00ean ch\u1ee9ng minh thu\u1ed1c kh\u00e1ng \u0111\u1ed9c t\u1ed1 ng\u1ef1a an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3 trong vi\u1ec7c \u0111i\u1ec1u tr\u1ecb u\u1ed1n v\u00e1n \u1edf ng\u01b0\u1eddi l\u1edbn - OUCRU<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.oucru.org\/vi\/nghien-cuu-dau-tien-chung-minh-thuoc-khang-doc-to-ngua-an-toan-va-hieu-qua-trong-viec-dieu-tri-uon-van-o-nguoi-lon\/\" \/>\n<meta property=\"og:locale\" content=\"vi_VN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Nghi\u00ean c\u1ee9u \u0111\u1ea7u ti\u00ean ch\u1ee9ng minh thu\u1ed1c kh\u00e1ng \u0111\u1ed9c t\u1ed1 ng\u1ef1a an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3 trong vi\u1ec7c \u0111i\u1ec1u tr\u1ecb u\u1ed1n v\u00e1n \u1edf ng\u01b0\u1eddi l\u1edbn - OUCRU\" \/>\n<meta property=\"og:description\" content=\"L\u1ea7n \u0111\u1ea7u ti\u00ean, m\u1ed9t th\u1eed nghi\u1ec7m \u0111\u1ed1i ch\u1ee9ng ng\u1eabu nhi\u00ean \u0111\u00e3 so s\u00e1nh hai ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb kh\u00e1ng \u0111\u1ed9c t\u1ed1 kh\u00e1c nhau cho b\u1ec7nh u\u1ed1n v\u00e1n. 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