Indonesia Brain Infection Study (IBIS)

Sponsor
RS Hasan Sadikin (RSHS) in Bandung
RS Cipto Mangunkusumo (RSCM) in Jakarta

Collaborators
Faculty of Medicine Universitas Padjajaran, Faculty of Medicine Universitas Indonesia, and OUCRU Indonesia, Radboud University

Principal Investigators
dr. Darma Imran, Sp.S(K)
dr. Sofiati Dian., SpS(K)., M.Kes., PhD
Dedeh Supantini, dr., SpS., M.Pd.Ked

Responsible Investigator
Assoc. Prof. Raph Hamers

Duration
December 2018 – ongoing

Status
Patient recruitment is ongoing at two hospitals, with about 1,100 patients enrolled so far.

The IBIS study is an observational cohort study seeking to describe the clinical presentation, causes, treatment, and outcome of patients with central nervous systems infections in Indonesia.

Background

The IBIS study aims to address the challenges posed by central nervous system (CNS) infections in Indonesia, such as meningitis, encephalitis, and brain abscesses. These diseases have caused significant illness and death, but their etiology has not been described well, diagnosis and treatment are often very difficult, and our understanding of risk factors and pathogenesis is incomplete.

The study collects information on CNS infections at two hospitals in Indonesia to enrich our understanding of these diseases and improve diagnosis, treatment, and intervention. The study also serves as a biorepository of patient samples for other research and may extend to other hospitals in the future.

Aim

The IBIS study seeks to describe the clinical presentation, causes, treatment, and outcomes of patients with central nervous system (CNS) infections in Indonesia.

Funding

The study initially received Dana Hibah Riset IPTEKKES funding from the Indonesian Ministry of Health in 2019 and currently receives support from the Medical Research Council and Wellcome Trust [110179/Z/15/Z].

Progress

The study has recruited 1,100 patients with suspected CNS infections at RSHS and RSCM. Data collected under this study can be and has been utilized by other studies, such as ULTIMATE, HARVEST, and ACT HIV.

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OUCRU Investigators

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PELAJARI SELENGKAPNYA

Related

Darma Imran

Dr Darma Imran

OUCRU logo dark

Dr Riwanti Estiasari

Professor Reinout van Crevel

Professor Reinout van Crevel

Broad

Broad Institute

FKUP

Faculty of Medicine, Universitas Padjadjaran

UI

Faculty of Medicine, University of Indonesia

RSHS

Hasan Sadikin Hospital

Radboud

Radboud University

RSUPN

RSUPN Cipto Mangunkusumo Jakarta

Forum Theatre Simulation

Analyse Tam’s choices. Step inside the story as an interactive spectator to break the chain of medical mishaps before it’s too late.

STORY TIMELINE PROGRESSION

5

The Ultimate Prevention: Vaccine Status

What if the volunteer leader had checked everyone’s Tetanus vaccination status before leaving for the field trip?

Vaccination Changes Everything

  • 100% Preventable: As you can see from our play, Tetanus cannot be cured easily once symptoms start and can be costly. But it is almost completely preventable with regular vaccination.
  • 10-Year Rule: Adults need a Tetanus booster shot every 10 years to maintain immunity.
  • Early booster shot: If you receive a deep or dirty cut (such as in the play, one from a rusty tool), you may need a booster if your last shot was more than 5 years ago.

When was your last Tetanus shot? Check your records today — a simple booster is the ultimate protection against unexpected accidents.

Forum Theatre Simulation

Analyse Tam’s choices. Step inside the story as an interactive spectator to break the chain of medical mishaps before it’s too late.

STORY TIMELINE PROGRESSION

4

Scenario Solved at Step 5!

Life-saving intervention! Jaw stiffness (lockjaw) is a classic symptom of active Tetanus toxin. Immediate hospital admission is required to secure the airway and control muscle spasms.

What if Tam had an ultimate shield against tetanus—protecting him from rusty tools before the trip even started?

Forum Theatre Simulation

Analyse Tam’s choices. Step inside the story as an interactive spectator to break the chain of medical mishaps before it’s too late.

STORY TIMELINE PROGRESSION

3

Scenario Solved at Step 4!

Good call! Healthcare providers depend on the full context. Clearly stating that an injury involved rusted metal alerts the nurse to assess Tetanus exposure immediately.

What if Tam had an ultimate shield against tetanus—protecting him from rusty tools before the trip even started?

Forum Theatre Simulation

Analyse Tam’s choices. Step inside the story as an interactive spectator to break the chain of medical mishaps before it’s too late.

STORY TIMELINE PROGRESSION

2

Scenario Solved at Step 3!

Spot on! Social media content often promotes unverified advice that delays crucial medical intervention. Deep, dirty cuts always require professional evaluation within hours.

What if Tam had an ultimate shield against tetanus—protecting him from rusty tools before the trip even started?

Forum Theatre Simulation

Analyse Tam’s choices. Step inside the story as an interactive spectator to break the chain of medical mishaps before it’s too late.

STORY TIMELINE PROGRESSION

1

Scenario Solved at Step 2!

Smart choice! Clostridium tetani bacteria thrive in organic material like dirt and leaves. Keeping raw plants out of deep cuts prevents pushing bacterial spores deeper into tissue.

What if Tam had an ultimate shield against tetanus—protecting him from rusty tools before the trip even started?

Forum Theatre Simulation

Analyse Tam’s choices. Step inside the story as an interactive spectator to break the chain of medical mishaps before it’s too late.

STORY TIMELINE PROGRESSION

1

Scenario Solved at Step 1!

Great call! By stopping work with high-risk, corroded tools, you removed the physical source of Tetanus exposure entirely before an injury could even happen.

What if Tam had an ultimate shield against tetanus—protecting him from rusty tools before the trip even started?

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