A Just Transitions framework for equitable and sustainable mitigation of antimicrobial resistance

Antimicrobial resistance (AMR) is a significant global concern, with 10 million annual deaths and US $100 trillion projected cost to the global economy by 2050 if no action is taken.

Like climate change, AMR is a multi-sectoral, borderless problem that disproportionately affects the poorest, and requires collective action and coordinated efforts. Urgent, system-wide change is needed to avoid a future where antimicrobials do not work, and common infections become life-threatening. Current efforts focus on solutions developed in high-income settings, which neglect structural challenges, particularly for poor communities where the disease burden is highest.

We aim to develop a framework for Just Transitions toward equitable and sustainable solutions to mitigate AMR. Our proposal outlines strategies to engage diverse groups of stakeholders to devise fair policies and regulatory tools, and has the potential to transform approaches to tackling AMR. Synergies with Just Transitions for agriculture and climate will have wider planetary health benefits.

Events

Meet the Team

Publications

A recent article in Trends in Microbiology examines why engagement and justice considerations are essential for effective AMR mitigation. The authors argue that technical solutions alone are insufficient and that inclusive, context-sensitive engagement strategies are critical to ensuring fair and sustainable AMR responses.

· Co-authors from the JT4AMR team: Phaik Yeong Cheah and Sonia Lewycka

· Link to Engagement and Justice in AMR Migration article.

A new paper in the Journal of Antimicrobial Chemotherapy analyses pharmaceutical sales data from 70 countries over more than two decades (2000–2022) to examine how gender inequality shapes patterns of antibiotic use. The findings reveal systematic associations between gendered social structures and antibiotic use, underscoring the importance of addressing inequality as part of equitable and effective AMR strategies.

Co-authors from the JT4AMR team: Deepshikha Batheja and Sonia Lewycka

Link to new paper in the Journal of Antimicrobial Chemotherapy.

A new review in Lancet Planetary Health, produced with the Pharma Pollution Hub at Exeter, assesses the environmental impacts of UK healthcare-related pharmaceutical pollution and potential mitigation options. The paper considers both technical fixes and upstream interventions, highlighting opportunities to reduce environmental harms while supporting broader AMR and sustainability goals.

Co-author from the JT4AMR team: Claas Kirchelle

Link to new review in Lancet Planetary Health.

Published in Lancet Microbe, this article examines the unintended consequences that can arise from AMR policies and interventions. The paper is particularly timely in light of the new draft Global Action Plan, offering critical reflections on how AMR strategies can be designed to avoid reinforcing inequities or creating new harms.

Co-authors from the JT4AMR team: Claas Kirchhelle, Stephen Hinchliffe, Sonia Lewycka, Sassy Molyneux, Edna Mutua, and Clare Chandler

Link to Lancet Microbe article.

Published in the Journal of Public Health in Africa, this paper presents insights from a multidisciplinary workshop examining how climate change is reshaping risks and responses to antimicrobial resistance. The article highlights governance challenges, knowledge gaps, and priorities for integrated climate–health–AMR approaches, with particular attention to low- and middle-income country contexts.

Co-authors from the JT4AMR team: Deepshikha Batheja and Esmita Charani

Link to article in Journal of Public Health in Africa.

A new Special Issue in ‘Public Humanities, Antimicrobial Resistance: Just Transitions for Shared Futures’ brings together scholars from the humanities, social sciences and global health to re‑imagine how we live with AMR and our microbial world. Guest edited by Dr Sheila Varadan, Dr Sara de Wit, Dr Miriam Waltz and Dr Claas Kirchhelle, the issue applies “just transitions” – a concept rooted in climate justice – to draw out the societal, ethical and ecological dimensions of AMR.

With humanities and social science scholars from over 20 countries, this issue interrogates AMR through a global lens using four interlinked themes: justice, equity, inclusivity and governance. Authors explore how justice must extend to marginalised communities and even non‑human life; how structural inequalities shape vulnerability and access to treatment; how inclusive, participatory governance can improve public engagement; and how global policy must move beyond short‑term stewardship to the sustainable and equitable management of microbial environments.

Read the full Public Humanities, Antimicrobial Resistance: Just Transitions for Shared Futures Special Issue, available Open-Access.

Find out more about the “Just Transitions for AMR Global Convening Programme”, funded by the British Academy:

For further inquiries or questions, please contact Sheila Varadan (Guest Editor, s.r.varadan@law.leidenuniv.nl) Claas Kirchhelle (Guest Editor, claas.kirchhelle@inserm.fr) or Sonia Lewycka (Co-Principal Investigator, Just Transitions for AMR Working Group, slewycka@oucru.org)

A new journal from Cambridge University Press, Public Humanities is a venue for scholars, students, activists, journalists, policy-makers, professionals, practitioners, and non-specialists to connect and share knowledge about human creativity and culture. The journal combines rigorous peer-reviewed research with accessible writing, delivering of-the-moment knowledge about about the intersections of humanities scholarship and public life in free-to-read articles.

In this commentary, Deepshikha Batheja, Sonia Lewycka, Srishti Goel and others argue that gender and equity considerations should be central to the revised Global Action Plan (GAP) on Antimicrobial Resistance (AMR) to ensure responses are effective, inclusive, and sustainable.

The authors propose that each GAP pillar explicitly incorporates gender and equity concerns, highlighting how social and structural determinants influence exposure, vulnerability, and access to AMR-related interventions. The paper provides concrete recommendations for embedding these commitments across AMR governance, surveillance, communication, policy development, and implementation, demonstrating that addressing inequities is essential to strengthening global AMR action.

Link to Revised Global Action Plan (GAP) on Antimicrobial Resistance (AMR) article.

In this commentary, Tess Johnson, Lorenz von Seidline and Phaik Yeong Cheah argue that antimalarial resistance and antibacterial resistance raise distinct ethical considerations. Unlike antibacterial resistance, mitigating antimalarial resistance has well-defined goals and does not involve environmental factors or the use in livestock. These differences make it clear that not all microbes should be addressed in the same way, and that interventions must be tailored accordingly.

Published in BMJ Global Health 2025;10:e018943.

Link to A just war on bugs? Ethical differences between antimalarial resistance and antibacterial resistance article.

In this comment, ‘Beyond breakpoint – reconceptualising AMR as a symptom of planetary stress’, Kirchhelle and Roberts (2025) challenge conventional clinical framings of antimicrobial resistance (AMR) by redefining it as a symptom of planetary ecosystem stress, thereby embedding it in the broader discourse on planetary health. They argue that AMR acts as a microbial barometer of anthropogenic disturbance and is consequently a vital indicator of ecological imbalance.

The authors illustrate how the global proliferation of AMR reflects the destabilisation of microbial ecosystems under relentless chemical and environmental pressures. Recognising AMR as an ecological stress signal could reframe stewardship approaches and lead to a paradigm shift in AMR governance.

This situates microbial health within international legal frameworks while advocating for policies that safeguard the microbial commons, potentially a significant step forward towards more holistic planetary stewardship.

Link to Beyond breakpoint – reconceptualising AMR as a symptom of planetary stressarticle.

This commentary explores whether there is epistemic injustice in global antimicrobial resistance (AMR) research – who sets priorities, who produces knowledge, and which types of knowledge are valued. We argue that epistemic injustice may have created blind spots in policy. Addressing this requires a commitment to diversity, equity, and inclusion.
 
 

December 2024, Monash Bioethics Review. Issue editor, Tess Johnson.

This issue of ‘Monash Bioethics Review’ explores antimicrobial resistance (AMR) as a threat to global health, and focuses particularly on the social justice implications of measures to prevent, reduce, and innovate against AMR. Whilst AMR poses harm across the globe, these harms are not uniformly distributed among populations, either temporally or geographically. This is one facet of considering justice in the AMR context. Furthermore, the risks of resistance developing are not uniformly distributed, implying that there may be AMR ‘hotspots’ (in time and space) for which it is more effective to intervene using stewardship, surveillance, and/or innovation.

The burdens of these interventions ought to be considered in comparison to the benefits to the populations of hotspots compared to other populations. Where greater harms are borne by already disadvantaged populations, there is the potential for interventions against AMR to exacerbate existing social injustice. Stewardship, surveillance and innovation measures must be ethically evaluated through this lens.”

Commenting on the relevance and timeliness of this publication, issue editor Tess Johnson said: “I’ve been interested in this area ever since the pandemic. It’s amazing how much attention big, urgent threats get, but it’s easy for us to forget about ongoing and multifaceted health issues, like drug resistance”.

A review by Deepshika Batheja and Srishti Goel that explores how biological, sociocultural and behavioural factors contribute to the differential incidence of AMR in women, delving into the gendered implications that are often overlooked when it comes to the threat of AMR.

October 17, 2024, Monash Bioethics Review

A paper, by Edna Mutua and contributors, that deals with the question of morality in AMR discourse as seen through data collected on antibiotic prescription, dispensing and use in human and livestock health in Tanzania.

October 5, 2024, SSM – Qualitative Research in Health

An ethnographic study (with Clare Chandler as contributor) looking at the present and everyday realities of AMR for frail bedridden patients through the theoretical lenses of precarity and care.

September 18, 2024, The Lancet Global Health

A comment piece (with Sonia Lewycka and Rogier van Doorn as contributors) about access to diagnostics (CRP testing) in low-income and middle-income countries to prevent overuse of antimicrobials.

June 22, 2024, Health Policy and Planning

A study on Point-of-care tests (with Clare Chandler as contributor) that reveals social and temporal intersections between processes of technological innovation and health systems.

3 April, 2024, BMJ Global Health

This article (with Phaik Yeong Cheah and Tess Johnson as contributors) delves into the ethical tensions that might make it difficult to address or solve the complex issue of Antimicrobial resistance (AMR). The ethical analysis reveals multiple competing interests and unresolved ethical tensions, drawing from existing evidence and the experiences of the contributors living and working in low-income and middle-income countries. To be effective, AMR policies need to take all these tensions into account and find solutions that service those who are worst affected by AMR.

November 17, 2023, The Conversation

An article by Marina Joubert, Phaik Yeong Cheah and Sonia Lewycka, written for World AMR Awareness Week, on the threat of AMR and why the global response needs to be fair to all. It includes the call for a new approach to solutions that prioritise equity and sustainability and the importance of embedding public and community voices.

 

September 08, 2023, The Lancet

A comment piece written by the Just Transitions for AMR Working Group outlining the need for a just transition approach for antimicrobial resistance in order to prioritise justice, sustainability, inclusivity and equity in the planning for a future with AMR.

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