Correlation Of Antibiotic Killing Activities, Bacterial Genotype And Clinical Response

100% Preventable: As you can see from our play, Tetanus cannot be cured easily once symptoms start and can be costly. But it is almost completely preventable with regular vaccination.
10-Year Rule: Adults need a Tetanus booster shot every 10 years to maintain immunity.
Early booster shot: If you receive a deep or dirty cut (such as in the play, one from a rusty tool), you may need a booster if your last shot was more than 5 years ago.

This project aims to understand the level of correlation between in vitro killing activities of antibiotic(s) and in vivo clinical responses and link that with bacterial genotypes/phenotypes.

Such information is important to predict/define antibiotic treatment responses and strengthen antibiotic stewardship programmes.

For example, we are measuring in vitro and intracellular killing activities of azithromycin and comparing that with the patient’s treatment responses to azithromycin from the ACT-South Asia trial to evaluate its ongoing efficacy, devise appropriate dosing regimens, and inform effective antibiotic stewardship.

Furthermore, in vitro testing of new antibiotics such as ceftazidime-avibactam, ceftolozane-tazobactam, new beta-lactamase inhibitor combinations against carbapenem-resistant Gram-negative bacilli exhibiting diverse molecular mechanisms of carbapenem resistance is being conducted in our lab.