Genetic Diversity And Epidemiological Landscape Of Extra-Intestinal Pathogenic E. Coli In Vietnam

Funder
Wellcome

Principal Investigator
Dr Pham Thanh Duy

In this study, we adopt the CH-typing method to rapidly screen for significant multidrug-resistant extra-intestinal pathogenic E. coli (ExPEC) clones that are associated with human infections as well as healthy carriers and animals.

Multidrug-resistant extra-intestinal pathogenic E. coli (ExPEC) has emerged as the leading cause of bloodstream infections in Vietnam and many Asian countries. The ecological reservoirs, host risk factors and modes of transmission of ExPEC clones are currently understudied.

In this study, we adopt the CH-typing method to rapidly screen for significant ExPEC clones that are associated with human infections as well as healthy carriers and animals. Predominant clones are subsequently subjected to whole genome sequencing, and genomic data are combined with relevant epidemiological information to investigate the transmission cycle, AMR development and risk factors associated with coli BSIs.

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OUCRU Investigators

PELAJARI SELENGKAPNYA

Related

Nguyen Phu Huong Lan – Enteric Infections

Dr Nguyễn Phú Hương Lan

Forum Theatre Simulation

Analyse Tam’s choices. Step inside the story as an interactive spectator to break the chain of medical mishaps before it’s too late.

STORY TIMELINE PROGRESSION

5

The Ultimate Prevention: Vaccine Status

What if the volunteer leader had checked everyone’s Tetanus vaccination status before leaving for the field trip?

Vaccination Changes Everything

  • 100% Preventable: As you can see from our play, Tetanus cannot be cured easily once symptoms start and can be costly. But it is almost completely preventable with regular vaccination.
  • 10-Year Rule: Adults need a Tetanus booster shot every 10 years to maintain immunity.
  • Early booster shot: If you receive a deep or dirty cut (such as in the play, one from a rusty tool), you may need a booster if your last shot was more than 5 years ago.

When was your last Tetanus shot? Check your records today — a simple booster is the ultimate protection against unexpected accidents.

Forum Theatre Simulation

Analyse Tam’s choices. Step inside the story as an interactive spectator to break the chain of medical mishaps before it’s too late.

STORY TIMELINE PROGRESSION

4

Scenario Solved at Step 5!

Life-saving intervention! Jaw stiffness (lockjaw) is a classic symptom of active Tetanus toxin. Immediate hospital admission is required to secure the airway and control muscle spasms.

What if Tam had an ultimate shield against tetanus—protecting him from rusty tools before the trip even started?

Forum Theatre Simulation

Analyse Tam’s choices. Step inside the story as an interactive spectator to break the chain of medical mishaps before it’s too late.

STORY TIMELINE PROGRESSION

3

Scenario Solved at Step 4!

Good call! Healthcare providers depend on the full context. Clearly stating that an injury involved rusted metal alerts the nurse to assess Tetanus exposure immediately.

What if Tam had an ultimate shield against tetanus—protecting him from rusty tools before the trip even started?

Forum Theatre Simulation

Analyse Tam’s choices. Step inside the story as an interactive spectator to break the chain of medical mishaps before it’s too late.

STORY TIMELINE PROGRESSION

2

Scenario Solved at Step 3!

Spot on! Social media content often promotes unverified advice that delays crucial medical intervention. Deep, dirty cuts always require professional evaluation within hours.

What if Tam had an ultimate shield against tetanus—protecting him from rusty tools before the trip even started?

Forum Theatre Simulation

Analyse Tam’s choices. Step inside the story as an interactive spectator to break the chain of medical mishaps before it’s too late.

STORY TIMELINE PROGRESSION

1

Scenario Solved at Step 2!

Smart choice! Clostridium tetani bacteria thrive in organic material like dirt and leaves. Keeping raw plants out of deep cuts prevents pushing bacterial spores deeper into tissue.

What if Tam had an ultimate shield against tetanus—protecting him from rusty tools before the trip even started?

Forum Theatre Simulation

Analyse Tam’s choices. Step inside the story as an interactive spectator to break the chain of medical mishaps before it’s too late.

STORY TIMELINE PROGRESSION

1

Scenario Solved at Step 1!

Great call! By stopping work with high-risk, corroded tools, you removed the physical source of Tetanus exposure entirely before an injury could even happen.

What if Tam had an ultimate shield against tetanus—protecting him from rusty tools before the trip even started?

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