His research integrates advanced molecular biology and genomics with epidemiological surveillance and clinical study to address drug-resistant bacterial infections in Viet Nam and across Asia.

He has been working on typhoid fever (S. Typhi and S. Paratyphi A), and diarrheal diseases (i.e. diarrhea-causing E*. coli, Shigella spp*) since 2008, and have recently expanded his research interests in bloodstream infections (i.e. E. coli, K. pneumoniae), and nosocomial infections (i.e. A. baumanii, K. pneumoniae).

His research aims to provide a better understanding of the evolution, transmission dynamics, and clinical impact of drug-resistant bacteria in low- and middle-income settings for guiding public health interventions and improving clinical practices.

His current project focuses on combining genomics, RNA sequencing and evolutionary experiments with a clinical study to investigate the emergence and impact of azithromycin-resistant Salmonella Typhi, the causative agent of typhoid fever. Additional projects include understanding the impact of antimicrobial exposure on the human gut microbiome, horizontal gene transfer, and the development of drug resistance. He is also working on studying the ecology and evolution of hypervirulence and antimicrobial resistance in Klebsiella pneumoniae.