Genomic Surveillance Of Hypervirulent And Antimicrobial Resistant Klebsiella Pneumoniae Causing Bloodstream Infections In Vietnam

Funder
Wellcome

Principal Investigator
Dr Pham Thanh Duy

This study reconstructs phylogenetic structure, transmission dynamics and virulence plasmid structures of hypervirulent (+/- AMR) K. pneumoniae in Vietnam between 2010-2020.

In this study, we perform Illumina and Nanopore sequencing of a collection of hypervirulent pneumoniae identified from bloodstream infection cases and healthy individuals to reconstruct phylogenetic structure, transmission dynamics and virulence plasmid structures of hypervirulent (+/- AMR) K. pneumoniae in Vietnam between 2010-2020.

We also investigate the horizontal transfer of virulence plasmids between different hosts under the presence of naturally occurring conjugative helper plasmids and phagemids. This study will provide new insights into the ecology, transmission, and genetic structure of hypervirulent (+/- AMR) K. pneumoniae, which is responsible for the increasing prevalence of severe community-acquired bloodstream infections in Vietnam and SEA in recent years.

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OUCRU Investigators

PELAJARI SELENGKAPNYA

Related

Dr. Juan Carrique Mas

Dr Juan Carrique-Mas

Nguyen Phu Huong Lan – Enteric Infections

Dr Nguyễn Phú Hương Lan

Forum Theatre Simulation

Analyse Tam’s choices. Step inside the story as an interactive spectator to break the chain of medical mishaps before it’s too late.

STORY TIMELINE PROGRESSION

5

The Ultimate Prevention: Vaccine Status

What if the volunteer leader had checked everyone’s Tetanus vaccination status before leaving for the field trip?

Vaccination Changes Everything

  • 100% Preventable: As you can see from our play, Tetanus cannot be cured easily once symptoms start and can be costly. But it is almost completely preventable with regular vaccination.
  • 10-Year Rule: Adults need a Tetanus booster shot every 10 years to maintain immunity.
  • Early booster shot: If you receive a deep or dirty cut (such as in the play, one from a rusty tool), you may need a booster if your last shot was more than 5 years ago.

When was your last Tetanus shot? Check your records today — a simple booster is the ultimate protection against unexpected accidents.

Forum Theatre Simulation

Analyse Tam’s choices. Step inside the story as an interactive spectator to break the chain of medical mishaps before it’s too late.

STORY TIMELINE PROGRESSION

4

Scenario Solved at Step 5!

Life-saving intervention! Jaw stiffness (lockjaw) is a classic symptom of active Tetanus toxin. Immediate hospital admission is required to secure the airway and control muscle spasms.

What if Tam had an ultimate shield against tetanus—protecting him from rusty tools before the trip even started?

Forum Theatre Simulation

Analyse Tam’s choices. Step inside the story as an interactive spectator to break the chain of medical mishaps before it’s too late.

STORY TIMELINE PROGRESSION

3

Scenario Solved at Step 4!

Good call! Healthcare providers depend on the full context. Clearly stating that an injury involved rusted metal alerts the nurse to assess Tetanus exposure immediately.

What if Tam had an ultimate shield against tetanus—protecting him from rusty tools before the trip even started?

Forum Theatre Simulation

Analyse Tam’s choices. Step inside the story as an interactive spectator to break the chain of medical mishaps before it’s too late.

STORY TIMELINE PROGRESSION

2

Scenario Solved at Step 3!

Spot on! Social media content often promotes unverified advice that delays crucial medical intervention. Deep, dirty cuts always require professional evaluation within hours.

What if Tam had an ultimate shield against tetanus—protecting him from rusty tools before the trip even started?

Forum Theatre Simulation

Analyse Tam’s choices. Step inside the story as an interactive spectator to break the chain of medical mishaps before it’s too late.

STORY TIMELINE PROGRESSION

1

Scenario Solved at Step 2!

Smart choice! Clostridium tetani bacteria thrive in organic material like dirt and leaves. Keeping raw plants out of deep cuts prevents pushing bacterial spores deeper into tissue.

What if Tam had an ultimate shield against tetanus—protecting him from rusty tools before the trip even started?

Forum Theatre Simulation

Analyse Tam’s choices. Step inside the story as an interactive spectator to break the chain of medical mishaps before it’s too late.

STORY TIMELINE PROGRESSION

1

Scenario Solved at Step 1!

Great call! By stopping work with high-risk, corroded tools, you removed the physical source of Tetanus exposure entirely before an injury could even happen.

What if Tam had an ultimate shield against tetanus—protecting him from rusty tools before the trip even started?

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