Tran Thuy Vi
Research Assistant, Dengue Group
I did my undergraduate degree and subsequent Master of Science in Biotechnology at the International University in Ho Chi Minh City, Vietnam from 2013 to 2015. My undergraduate research dissertation, entitled : “The prevalence and pattern of human immunodeficiency virus drug resistance in antiretroviral naive individuals starting antiretroviral therapy in Hanoi, Viet Nam 2011-2013”, was conducted at the Oxford University Clinical Research Unit (OUCRU) in Ho Chi Minh City. After graduating, I joined the Dengue group at OUCRU to further develop my career in research.
Currently my work involves developing molecular diagnostics for Dengue, Chikungunya and Zika viruses and studying the evolution of dengue virus lineages. We are currently using realtime PCR and NGS for high throughput diagnostics. With respect to molecular evolution of dengue virus, we are going to employ NGS to test the hypothesis that DENV do not adapt to viral interference properties of Wolbachia during repeated mosquito passage, and also to investigate whether DENV that have been repeatedly passaged in mosquitoes are attenuated for replication in human cells. We have successfully developed a NGS-based method to sequence large collections of specimen using the Illumina MiSeq platform. Analyzing such large datasets is a serious challenge requiring high-level bioinformatics capacity. Therefore, my current research interest is using bioinformatics to accurately analyze and interpret the large data sets.
Carrington LB, Tran BCN, Le NTH, Luong TTH, Nguyen TT, Nguyen PT, Nguyen CVV, Nguyen HTC, Vu TT, Vo LT, Le DT, Vu NT, Nguyen GT, Luu HQ, Dang AD, Hurst TP, O’Neill SL, Tran VT, Kien DTH, Nguyen NM, Wolbers M, Wills B, Simmons CP. Field- and clinically derived estimates of Wolbachia-mediated blocking of dengue virus transmission potential in Aedes aegypti mosquitoes. Proc Natl Acad Sci U S A. 2018 Jan 9;115(2):361-366. doi: 10.1073/pnas.1715788115. Epub 2017 Dec 26. PubMed PMID: 29279375; PubMed Central PMCID: PMC5777059.
Quyen NTH, Kien DTH, Rabaa M, Tuan NM, Vi TT, Van Tan L, Hung NT, Tuan HM, Van Tram T, Le Da Ha N, Quang HK, Doanh NQ, Van Vinh Chau N, Wills B, Simmons CP. Chikungunya and Zika Virus Cases Detected against a Backdrop of Endemic Dengue Transmission in Vietnam. Am J Trop Med Hyg. 2017 Jul;97(1):146-150. doi:10.4269/ajtmh.16-0979. PubMed PMID: 28719300; PubMed Central PMCID: PMC5508909.