Influence Of Mycobacterial And Host Factors On Antibiotic Resistance And Tolerance Of Mycobacterium Tuberculosis

Funder
Wellcome

Duration
2018 – 2023

Principal Investigator
Associate Professor Nguyen Thuy Thuong Thuong

 

This study will investigate drug-tolerant tuberculosis (TB) bacterial cells in TB patients to understand their frequency, the factors that govern their development, and how their presence might influence the outcomes of treatment.

Background

Tuberculosis (TB) requires drug treatment for several months to be cured, possibly because some of the TB-causing bacteria are tolerant to the drugs and continue to survive when the rest of the bacteria are killed. These tolerant TB bacteria may delay the cure of TB and may also lead to the reappearance of TB when treatment is stopped.

The number of tolerant bacteria and the factors leading to tolerance are poorly defined. It is important to understand tolerance better as it may lead to new drugs that overcome tolerance and thereby shorten the treatment of TB.

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OUCRU Investigators

Publications

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The 2021 WHO catalogue of Mycobacterium tuberculosis complex mutations associated with drug resistance: A genotypic analysis
Timothy M Walker, Paolo Miotto, Claudio U Koser, Philip W Fowler, Jeff Knaggs, Zamin Iqbal, Martin Hunt, Leonid Chindelevitch, Maha Farhat, Daniela Maria Cirillo, Inaki Comas, James Posey, Shaheed V Omar, Timothy EA Peto, Anita Suresh, Swapna Uplekar, Sacha Laurent, Rebecca E Colman, Carl-Michael Nathanson, Matteo Zignol, Ann Sarah Walker, The CRyPTIC Consortium, The Seq&Treat Consortium, Derrick W Crook, Nazir Ismail and Timothy C Rodwell
Lancet Microbe
March 8, 2022
DOI: 10.1016/S2666-5247(21)00301-3
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