Principal Investigators
Associate Professor Le Van Tan
Associate Professor Rogier van Doorn

Ho Chi Minh City and Hanoi, Viet Nam

Our aim is to better understand the natural history of the infection. This is important to inform the development of intervention strategies and is highly relevant for the current global response to the ongoing COVID-19 pandemic.


Most clinical research to date has been focusing on COVID-19 patients with moderately severe to severe disease because these are groups of patients that are admitted to hospitals for management worldwide. As a consequence, little is known about the natural history and transmission potential of completely asymptomatic and very mild infection with SARS-CoV-2.

We are in a unique position to study the natural history of SARS-CoV-2 infection due to the strict isolation, quarantine and contract tracing protocols enacted in Viet Nam. We are able, therefore, to recruit patients into our studies at all stages of infection, including pre- and asymptomatic carriers.

We also aim to evaluate the utility potential of wearable devices in monitoring COVID-19 patients remotely, thereby reducing the risk of transmission for healthcare workers.


  1. To describe the clinical, laboratory and virological characteristics of SARS-CoV-2 infection;
  2. To study the immune responses in SARS-CoV-2 infected patients;
  3. To identify potential protein markers that can predict severe disease;
  4. To unravel the evolutionary history of SARS-CoV-2 at both within the human host and population-level;
  5. to evaluate the utility potential of rapid antigen tests for the diagnostics and management of COVID-19 patients;
  6. To develop and sustain a research platform at key institutes and hospitals in Viet Nam to enable the country to rapidly respond to emerging infection outbreaks in the future.


Ton That Thanh, Nguyen Thi Thanh Nhan, Nguyen To Anh, Le Thanh Chung, Pham Thi Thuy Duyen, Le Thi Kim Chi, Nguyen Thi Hoai Thu, Pham Thi Hieu, Dinh Van Phuc, Pham Viet Son, Dang Quang Anh, Pham Thi Nam, Nguyen Tri Thuc, Nguyen Thi Hanh, Le Thi Thuy, Le Ly Thuy Tram, Le Kim Thanh, Nguyen Thi Han Ny, Le Nguyen Truc Nhu, Nguyen Van Vinh Chau, Guy Thwaites, Tran Tan Thanh, Le Van Tan.
J Infect
January 13, 2022
DOI: 10.1016/j.jinf.2022.01.010
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