Enhancing the Utility of SARS-CoV-2 Antibody Rapid Diagnostic Tests (RDTs) for Disease Surveillance

This project aims investigate if the integration of symptomatic, demographical and diet-related comorbidities data with antibody rapid diagnostic tests (RDTs) improves their potential to assess infection rates in addition to exposure, thereby broadening their utility for surveillance.


RDT-IgM/IgG-positive tests were associated with infection (OR 10.8, 95% CI 4.43 to 26.4, p<0.001) with an area under the curve (AUC) of 0.708% and 50% sensitivity, 91.5% specificity, 30.8% positive predictive value (PPV) and 96.1% negative predictive value (NPV).

RDT results combined with age, gender, contact history, symptoms and comorbidities increased the AUC to 0.787 and yielded 62.5% sensitivity, 87.0% specificity, 26.6% PPV and 96.9% NPV.

SARS-CoV-2 RDT-IgM/IgG results integrated with other predictors increased test sensitivity by 25% indicating the approach may be an affordable tool for epidemiological surveillance for population-based Covid-19 exposure and current infection, especially in groups with outbreaks or high transmission.

This may provide an affordable option for surveillance as RT-PCR is sensitive but costly, and antigen-based RDTs are cheap but of low sensitivity, and both detect current infection but not exposure, but SARS-CoV-2 IgM/IgG RDTs detect exposure but with poor sensitivity for current infection.


Dự Án Có Sự Tham Gia Của

Bài báo Nghiên cứu

Rina Agustina, Ari Fahrial Syam, Fadila Wirawan, Indah S Widyahening, Ahmad Jabir Rahyussalim, Yusra Yusra, Davrina Rianda, Erlina Burhan, Ngabila Salama, Rebekka Daulay, Ahmad Rhyza Vertando Halim, Anuraj H Shankar
BMJ Open
August 10, 2021
DOI: 10.1136/bmjopen-2020-047763

Liên quan

Rina Agustina

TS. Rina Agustina

Jakarta Health Office

Văn phòng Y tế Jakarta


Viện nghiên cứu và phát triển y tế quốc gia Indonesia

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