Clinical Epidemiology of Paediatric Covid-19 Delta Variant Cases from North Sumatra, Indonesia

Principal Investigators
Dr Anuraj Shankar
Dr Tryna Tania, Murni Teguh Memorial Hospital, Medan, North Sumatra, Indonesia
Dr Ariel Pradipta, GSI Laboratory, Jakarta, Indonesia

This study aims to examine the emergence and clinical impact and epidemiology of the Delta variant in paediatric COVID-19 patients from North Sumatra, Indonesia.


The impact of SARS-CoV-2 and it variants remains poorly understood. Moreover, few studies had reported on the presence, or the clinical relevance, of the Delta variant in children from a low- and middle-income country (LMIC).


We tracked the Delta variant among paediatric cases in North Sumatra, Indonesia, from June – July 2021.

Whole-genome sequences (WGS) from 18 new COVID-19 paediatric patients showed that 6 were B.1.459 and 6 were B.1.466.2, known variants in Indonesia in Clade 20A. Six were the Delta variant B.1.617.2 of Clade 21A, with 5 on one branch, and one on a distant branch consistent with that patient’s geographic separation, suggesting at least two introductions to the region. Variants tended to be spatially clustered, and four children with Delta variant had an adult infected household member, all of whom had lower real-time polymerase chain reaction (RT-PCR) cycle threshold (Ct) values compared to the child. No temporal trends were observed for Ct. These data support a paradigm shift with children being highly susceptible to the Delta variant and a priority for vaccination.


Dự Án Có Sự Tham Gia Của

Bài báo Nghiên cứu

Kusumawati RL, Lubis IND, Kumaheri, Pradipta A, Faksri K, Mutiara, Shankar AH, Tania T
Frontiers in Pediatrics
April 1, 2022
DOI: 10.3389/fped.2022.810404

Liên quan


Inke Nadia Diniyanti Lubis


R. Lia Kusumawati

Meutia A Kumaher

TS. Meutia A Kumaheri

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