Funder
UKAid, Foreign & Commonwealth Development Office
Principal Investigators
Professor A.M. Dondorp
Dr Erni Juwita Nelwan
Locations
Bangladesh
Cambodia
Jayapura City, Indonesia
Duration
June 2021 – March 2023
Loss of efficacy of first-line Artemisinin combination therapies (ACTs) jeopardises current malaria control and elimination efforts and will accelerate the spread of drug resistance. New antimalarial drugs are not expected to come to the market within the next five years.
There is an urgent need to evaluate alternative treatments using combinations of existing drugs which will not fall rapidly to resistance and can be deployed immediately. The deployment of Triple Artemisinin Combination Treatments (TACT) could be part of such a strategy.
This project aims to compare the efficacy, safety and tolerability of the TACTs artemether-lumefantrine+amodiaquine and artesunate-mefloquine+piperaquine and the standard ACTs artemether-lumefantrine+placebo, and artesunate-mefloquine+placebo.
In Indonesia, recruitment has not started yet. The trial documents are currently under submission to the Indonesian FDA and have been approved by The Ethics Committee of the Faculty of Medicine, University of Indonesia – Cipto Mangunkusumo Hospital on August 12th, 2022.
We anticipate fully enrolling this site with 235 P. falciparum patient subjects commencing in December 2022 before May 2023.
Analyse Tam’s choices. Step inside the story as an interactive spectator to break the chain of medical mishaps before it’s too late.
When was your last Tetanus shot? Check your records today — a simple booster is the ultimate protection against unexpected accidents.
Analyse Tam’s choices. Step inside the story as an interactive spectator to break the chain of medical mishaps before it’s too late.
What if Tam had an ultimate shield against tetanus—protecting him from rusty tools before the trip even started?
Analyse Tam’s choices. Step inside the story as an interactive spectator to break the chain of medical mishaps before it’s too late.
Good call! Healthcare providers depend on the full context. Clearly stating that an injury involved rusted metal alerts the nurse to assess Tetanus exposure immediately.
What if Tam had an ultimate shield against tetanus—protecting him from rusty tools before the trip even started?
Analyse Tam’s choices. Step inside the story as an interactive spectator to break the chain of medical mishaps before it’s too late.
What if Tam had an ultimate shield against tetanus—protecting him from rusty tools before the trip even started?
Analyse Tam’s choices. Step inside the story as an interactive spectator to break the chain of medical mishaps before it’s too late.
What if Tam had an ultimate shield against tetanus—protecting him from rusty tools before the trip even started?
Analyse Tam’s choices. Step inside the story as an interactive spectator to break the chain of medical mishaps before it’s too late.
What if Tam had an ultimate shield against tetanus—protecting him from rusty tools before the trip even started?
