Hanoi group

The Oxford Clinical Research Unit, Hanoi (OUCRU Hanoi) was established in 2006 and is hosted by the National Hospital of Tropical Diseases (NHTD). NHTD is a tertiary level teaching hospital, receiving infection related referrals from northern Vietnam and has close ties to the Ministry of Health (MoH).

Through its partnership with NHTD, OUCRU Hanoi also works with other hospitals and institutes in the region, including the National Institute for Hygiene and Epidemiology, the National Paediatric Hospital, the National Lung Hospital, National Center for Veterinary Diagnosis, and regional hospitals and health stations. The research programme at OUCRU Hanoi focuses on clinical and epidemiological aspects of respiratory infections (both bacterial and viral), antimicrobial resistance, zoonosis (including Streptococcus suis) and dengue. Furthermore, OUCRU Hanoi is studying zoonotic infections in collaboration with Hanoi Medical University as part of the VIZIONS project. Through NHTD OUCRU Hanoi has also been involved in consultations with MoH on antibiotic treatment guidelines, management of avian influenza and Streptococcus suis, and other public health issues.

The importance of OUCRU Hanoi in Viet Nam.

OUCRU Hanoi is close to all the key national institutes in Vietnam (see partners/collaborators) and the Ministry of Health. These relations ensure that OUCRU research findings also find their way into policies. Our research in the area of antibiotic resistance supported the development of a National Action Plan on Antibiotic Resistance that was signed by the Minister of Health mid 2013.

Our research locations

OUCRU Hanoi is based at the National Hospital of Tropical Diseases and. We also have research offices and laboratory capacity at National Institute of Hygiene and Epidemiology (NIHE), National Hospital of Paediatrics and Hanoi Medical University (HMU). With NIHE we now conduct influenza household transmission studies for over 7 years in Ha Nam. With HMU we conduct community based studies in Ba Vi and Dong Da.

Our OUCRU Hanoi researchers

FACULTY

  • Heiman Wertheim, Clinical Microbiologist. Heiman is the Unit Director and focuses on respiratory infections and antibiotic resistance.
  • Behzad Nadjm, Clinician. Baz heads the Clinical Trials Unit and works on respiratory infections.
  • Marc Choisy, Modeller, works on influenza and dengue at the National Institute of Hygiene and Epidemiology.

PHD STUDENTS

  • Huong Vu Thi Lan, Public Health Masters. Huong works on the burden of Streptococcus suis infections in Vietnam and risky food behaviour.
  • Do Thuy Nga, Pharmacist. Nga works on strategies to reduce antibiotic use in Vietnam.
  • Vu Dinh Phu, Doctor and head of ICU NHTD. Dr Phu works on hospital acquired infections on ICUs in Vietnam
  • Tran Thi Sinh, Microbiologist at NHP. Sinh works on improving laboratory diagnosis of pediatric tuberculosis.
  • Hoang Thi Thanh Thuy, Doctor and Coordinator national MDR TB program. Dr Thuy works on improving screening for MDR TB in Vietnam.
  • Le Nguyen Minh Hoa, PhD student. Hoa works on influenza immunology.
  • Diep, Veterinarian at National Center for Veterinary Diagnosis. Diep works on poultry antibody landscapes of avian influenza.

Our collaborations/partnerships

  • National Hospital of Tropical Diseases
  • National Institute of Hygiene and Epidemiology
  • Hanoi Medical University
  • National Hospital of Pediatrics
  • National Center for Veterinary Diagnosis
  • National Lung hospital

Key milestones

We recently completed a national program (VINARES) to assess hospital acquired infections, antibiotic use and antibiotic resistance in 16 hospitals across Vietnam. We had a closing meeting in October 2013 with 120 international participants in Hanoi.

We are running one of the longest influenza household cohorts worldwide in Ha Nam, Vietnam. This cohort has been ongoing for over 7 years leading to new knowledge in the area of influenza transmission and immunology.

Publications

Please see the Google Scholar page of OUCRU Hanoi for their publications. Some key publications are listed below:

Hoa LN, Bryant JE, Choisy M, Nguyet LA, Bao NT, Trang NH, Chuc NT, Toan TK, Saito T, Takemae N, Horby P, Wertheim H, Fox A. Population susceptibility to a variant swine-origin influenza virus A(H3N2) in Vietnam, 2011-2012. Epidemiol Infect. 2015 Mar 12:1-6. [Epub ahead of print] PubMed PMID: 25761949.

Tran HH, Ehsani S, Shibayama K, Matsui M, Suzuki S, Nguyen MB, Tran DN, Tran VP, Tran DL, Nguyen HT, Dang DA, Trinh HS, Nguyen TH, Wertheim HF. Common isolation of New Delhi metallo-beta-lactamase 1-producing Enterobacteriaceae in a large surgical hospital in Vietnam. Eur J Clin Microbiol Infect Dis. 2015 Mar 3. [Epub ahead of print] PubMed PMID: 25732142..

Pham DK, Chu J, Do NT, Brose F, Degand G, Delahaut P, De Pauw E, Douny C, Van Nguyen K, Vu TD, Scippo ML, Wertheim HF. Monitoring Antibiotic Use and Residue in Freshwater Aquaculture for Domestic Use in Vietnam. Ecohealth. 2015 Jan 6. [Epub ahead of print] PubMed PMID: 25561382.

Fonville JM, Wilks SH, James SL, Fox A, Ventresca M, Aban M, Xue L, Jones TC, Le NM, Pham QT, Tran ND, Wong Y, Mosterin A, Katzelnick LC, Labonte D, Le TT, van der Net G, Skepner E, Russell CA, Kaplan TD, Rimmelzwaan GF, Masurel N, de Jong JC, Palache A, Beyer WE, Le QM, Nguyen TH, Wertheim HF, Hurt AC, Osterhaus AD, Barr IG, Fouchier RA, Horby PW, Smith DJ. Antibody landscapes after influenza virus infection or vaccination. Science. 2014 Nov 21;346(6212):996-1000. doi: 10.1126/science.1256427. PubMed PMID: 25414313; PubMed Central PMCID: PMC4246172.

Huong VT, Hoa NT, Horby P, Bryant JE, Van Kinh N, Toan TK, Wertheim HF. Raw pig blood consumption and potential risk for Streptococcus suis infection, Vietnam. Emerg Infect Dis. 2014 Nov;20(11):1895-8. doi: 10.3201/eid2011.140915. PubMed PMID: 25340391; PubMed Central PMCID: PMC4214319.

Fox A, Mai le Q, Thanh le T, Wolbers M, Le Khanh Hang N, Thai PQ, Thi Thu Yen N, Minh Hoa le N, Bryant JE, Duong TN, Thoang DD, Barr IG, Wertheim H, Farrar J, Hien NT, Horby P. Hemagglutination inhibiting antibodies and protection against seasonal and pandemic influenza infection. J Infect. 2015 Feb;70(2):187-96. doi: 10.1016/j.jinf.2014.09.003. Epub 2014 Sep 16. PubMed PMID: 25224643; PubMed Central PMCID: PMC4309889.

Van Nguyen K, Zhang T, Thi Vu BN, Dao TT, Tran TK, Thi Nguyen DN, Thi Tran HK, Thi Nguyen CK, Fox A, Horby P, Wertheim H. Staphylococcus aureus nasopharyngeal carriage in rural and urban northern Vietnam. Trans R Soc Trop Med Hyg. 2014 Dec;108(12):783-90. doi: 10.1093/trstmh/tru132. Epub 2014 Sep 3. PubMed PMID: 25187670; PubMed Central PMCID: PMC4235569.

Thanh TH, Ngoc SD, Viet NN, Van HN, Horby P, Cobelens FG, Wertheim HF. A household survey on screening practices of household contacts of smear positive tuberculosis patients in Vietnam. BMC Public Health. 2014 Jul 11;14:713. doi: 10.1186/1471-2458-14-713. PubMed PMID: 25015682; PubMed Central PMCID: PMC4226947.

Huong VT, Ha N, Huy NT, Horby P, Nghia HD, Thiem VD, Zhu X, Hoa NT, Hien TT, Zamora J, Schultsz C, Wertheim HF, Hirayama K. Epidemiology, clinical manifestations, and outcomes of Streptococcus suis infection in humans. Emerg Infect Dis. 2014 Jul;20(7):1105-14. doi: 10.3201/eid2007.131594. PubMed PMID: 24959701; PubMed Central PMCID: PMC4073838.

Peto L, Nadjm B, Horby P, Ngan TT, van Doorn R, Van Kinh N, Wertheim HF. The bacterial aetiology of adult community-acquired pneumonia in Asia: a systematic review. Trans R Soc Trop Med Hyg. 2014 Jun;108(6):326-37. doi: 10.1093/trstmh/tru058. Epub 2014 Apr 29. Review. PubMed PMID: 24781376; PubMed Central PMCID: PMC4023908.

Thai PQ, Mai LQ, Welkers MR, Hang NL, Thanh LT, Dung VT, Yen NT, Duong TN, Hoa LN, Thoang DD, Trang HT, de Jong MD, Wertheim H, Hien NT, Horby P, Fox A. Pandemic H1N1 virus transmission and shedding dynamics in index case households of a prospective Vietnamese cohort. J Infect. 2014 Feb 1. pii: S0163-4453(14)00028-0. doi: 10.1016/j.jinf.2014.01.008. [Epub ahead of print] PubMed PMID: 24491598.

Nguyen KV, Thi Do NT, Chandna A, Nguyen TV, Pham CV, Doan PM, Nguyen AQ, Thi Nguyen CK, Larsson M, Escalante S, Olowokure B, Laxminarayan R, Gelband H, Horby P, Thi Ngo HB, Hoang MT, Farrar J, Hien TT, Wertheim HF. Antibiotic use and resistance in emerging economies: a situation analysis for Viet Nam. BMC Public Health. 2013 Dec 10;13:1158. doi: 10.1186/1471-2458-13-1158. PubMed PMID: 24325208.

Laxminarayan R, Duse A, Wattal C, Zaidi AK, Wertheim HF, Sumpradit N, Vlieghe E, Hara GL, Gould IM, Goossens H, Greko C, So AD, Bigdeli M, Tomson G, Woodhouse W, Ombaka E, Peralta AQ, Qamar FN, Mir F, Kariuki S, Bhutta ZA, Coates A, Bergstrom R, Wright GD, Brown ED, Cars O. Antibiotic resistance-the need for global solutions. Lancet Infect Dis. 2013 Dec;13(12):1057-98. doi:10.1016/S1473-3099(13)70318-9. Epub 2013 Nov 17. Erratum in: Lancet Infect Dis. 2014 Jan;14(1):11. PubMed PMID: 24252483.

Le MQ, Horby P, Fox A, Nguyen HT, Le Nguyen HK, Hoang PM, Nguyen KC, de Jong MD, Jeeninga RE, Rogier van Doorn H, Farrar J, Wertheim HF. Subclinical avian influenza A(H5N1) virus infection in human, Vietnam. Emerg Infect Dis. 2013 Oct;19(10):1674-7. doi: 10.3201/eid1910.130730. PubMed PMID: 24047510; PubMed Central PMCID: PMC3810763.

Hoang TH, Wertheim H, Minh NB, Duong TN, Anh DD, Phuong TT, Son TH, Izumiya H, Ohnishi M, Shibayama K, Hien NT. Carbapenem-resistant Escherichia coli and Klebsiella pneumoniae strains containing New Delhi metallo-beta-lactamase isolated from two patients in Vietnam. J Clin Microbiol. 2013 Jan;51(1):373-4. doi: 10.1128/JCM.02322-12. Epub 2012 Oct 24. PubMed PMID: 23100353; PubMed Central PMCID: PMC3536186.

Tran ST, Renschler JP, Le HT, Dang HT, Dao TM, Pham AN, Nguyen LT, Van Nguyen H, Thi Thu Nguyen T, Ngoc Le S, Fox A, Caws M, Thi Quynh N, Horby P, Wertheim H. Diagnostic accuracy of microscopic Observation Drug Susceptibility (MODS) assay for pediatric tuberculosis in Hanoi, Vietnam. PLoS One. 2013 Sep 4;8(9):e72100. doi: 10.1371/journal.pone.0072100. eCollection 2013. PubMed PMID: 24023726; PubMed Central PMCID: PMC3762843.

Wertheim HF, Chandna A, Vu PD, Pham CV, Nguyen PD, Lam YM, Nguyen CV, Larsson M, Rydell U, Nilsson LE, Farrar J, Nguyen KV, Hanberger H. Providing impetus, tools, and guidance to strengthen national capacity for antimicrobial stewardship in Viet Nam. PLoS Med. 2013;10(5):e1001429. doi: 10.1371/journal.pmed.1001429. Epub 2013 May 7. PubMed PMID: 23667342; PubMed Central PMCID: PMC3646721.

Taylor WR, Nguyen K, Nguyen D, Nguyen H, Horby P, Nguyen HL, Lien T, Tran G, Tran N, Nguyen HM, Nguyen T, Nguyen HH, Nguyen T, Tran G, Farrar J, de Jong M, Schultsz C, Tran H, Nguyen D, Vu B, Le H, Dao T, Nguyen T, Wertheim H. The spectrum of central nervous system infections in an adult referral hospital in Hanoi, Vietnam. PLoS One. 2012;7(8):e42099. doi: 0.1371/journal.pone.0042099. Epub 2012 Aug 30. PubMed PMID: 22952590; PubMed Central PMCID: PMC3431395.

Horby P, Nguyen NY, Dunstan SJ, Baillie JK. The role of host genetics in susceptibility to influenza: a systematic review. PLoS One. 2012;7(3):e33180. doi: 0.1371/journal.pone.0033180. Epub 2012 Mar 15. Review. PubMed PMID: 22438897; PubMed Central PMCID: PMC3305291.

Horby P, Mai le Q, Fox A, Thai PQ, Thi Thu Yen N, Thanh le T, Le Khanh Hang N, Duong TN, Thoang DD, Farrar J, Wolbers M, Hien NT. The epidemiology of interpandemic and pandemic influenza in Vietnam, 2007-2010: the Ha Nam household cohort study I. Am J Epidemiol. 2012 May 15;175(10):1062-74. doi: 10.1093/aje/kws121. Epub 2012 Mar 12. PubMed PMID: 22411862; PubMed Central PMCID: PMC3353138.

Fox A, Le NM, Simmons CP, Wolbers M, Wertheim HF, Pham TK, Tran TH, Trinh TM, Nguyen TL, Nguyen VT, Nguyen DH, Farrar J, Horby P, Taylor WR, Nguyen VK. Immunological and viral determinants of dengue severity in hospitalized adults in Ha Noi, Viet Nam. PLoS Negl Trop Dis. 2011 Mar 1;5(3):e967. doi: 10.1371/journal.pntd.0000967. PubMed PMID: 21390156; PubMed Central PMCID: PMC3046970

Horby P, Pham QT, Hens N, Nguyen TT, Le QM, Dang DT, Nguyen ML, Nguyen TH, Alexander N, Edmunds WJ, Tran ND, Fox A, Nguyen TH. Social contact patterns in Vietnam and implications for the control of infectious diseases. PLoS One. 2011 Feb 14;6(2):e16965. doi: 10.1371/ journal.pone.0016965. PubMed PMID: 21347264; PubMed Central PMCID: PMC3038933.

Horby P, Wertheim H, Ha NH, Trung NV, Trinh DT, Taylor W, Ha NM, Lien TT, Farrar J, Van Kinh N. Stimulating the development of national Streptococcus suis guidelines in Viet Nam through a strategic research partnership. Bull World Health Organ. 2010 Jun;88(6):458-61. doi: 10.2471/BLT.09.067959. Epub 2010 Jan 26. PubMed PMID: 20539860; PubMed Central PMCID: PMC2878145.

Wertheim HF, Nguyen HN, Taylor W, Lien TT, Ngo HT, Nguyen TQ, Nguyen BN, Nguyen HH, Nguyen HM, Nguyen CT, Dao TT, Nguyen TV, Fox A, Farrar J, Schultsz C, Nguyen HD, Nguyen KV, Horby P. Streptococcus suis, an important cause of adult bacterial meningitis in northern Vietnam. PLoS One. 2009 Jun 22;4(6):e5973. doi: 10.1371/journal.pone.0005973. PubMed PMID: 19543404; PubMed Central PMCID:PMC2696092.

Wertheim HF, Nguyen TQ, Nguyen KA, de Jong MD, Taylor WR, Le TV, Nguyen HH, Nguyen HT, Farrar J, Horby P, Nguyen HD. Furious rabies after an atypical exposure. PLoS Med. 2009 Mar 17;6(3):e44. doi: 10.1371/journal.pmed.1000044. PubMed PMID: 19296718; PubMed Central PMCID: PMC2656546.