Sophie Yacoub

Associate Professor Sophie Yacoub

Head of Dengue Group

Assoc. Prof. Sophie Yacoub, BM, MRCP, PhD, MSc, DTM&H is currently leading a large translational programme of dengue research, focusing on pathogenesis studies, precision medicine clinical trials and innovative technology centred on wearable devices, physiological monitoring and utilizing AI for medical imaging and clinical decision support systems.

In addition, Sophie is a Wellcome Clinical Career Development Fellow and a Physician in Infectious Diseases and General Medicine and holds an honorary consultant appointment at London North West University Healthcare NHS Trust in the UK.

She is a member of the Royal College of Physicians in London. Her work has been supported by grants from Wellcome, NMRC Singapore, WHO, the British Heart Foundation and the Royal Society of Tropical Medicine.

Under hear leadership, dengue group is also investigating the impact of climate change and global heating on dengue and other climate-sensitive diseases in Southeast Asia through the integration of novel digital technologies, remote patient monitors, mHealth initiatives and AI methodologies. The overall aim of the group is to improve dengue clinical outcomes in Viet Nam and globally.

Timeline

PhD

Imperial College London, UK

MSc.

London School of Hygiene and Tropical Medicine, UK

Publications

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The influence of fluid resuscitation strategy on outcomes from dengue shock syndrome: a review of the management of 691 children in 7 Southeast Asian hospitals
Huynh Trung Trieu, Nguyen Lam Vuong, Nguyen Thanh Hung, Tuan Nguyen Minh, Vinh Chau Nguyen Van, Tu Qui Phan, Truong An Nguyen, Su Nguyen Thi Minh, An Nguyen Thi Truong, Em Jun Min, Heng Kai Voon, Shirley Chan Huey Ling, Hue Yuen Ling, Lim Eng Seng, Lucy Lum Chai See, Sharifah Faridah Syed Omar, Amnasewary Ramakrishnan, Aiu Jer Ling, Alia Zubaidah Bahtar, Nachal Nachiappan, Kyaw Zin Wai, Kyi San Thi, Yee Mon Lwin, Nick Ward, Anushka Ward, Sophie Yacoub, Hung Trinh, Phung Khanh Lam, Bridget Wills
BMJ Glob Health
March 11, 2025
DOI: 10.1136/bmjgh-2024-017538
Anakinra for dengue patients with hyperinflammation: protocol for a randomized double-blind placebo-controlled trial
Tran Bang Huyen; Huynh Trung Trieu; Nguyen Lam Vuong; Nguyen Minh Nguyet; Dong Thi Hoai Tam; Angela McBride; Nguyen Thi My Linh; Dang Trong Thuan; Nguyen Thanh Phong; Truong Ngoc Trung; Nguyen Thi Cam Huong; Tran Thi Dong Vien; Huynh Thi Le Duyen; Vo Thi My Hoa; James Watson; Ronald Geskus; Phan Vinh Tho; Evelyne Kestelyn; Phan Tu Qui; Sophie Yacoub.
Wellcome Open Res
November 23, 2024
DOI: https://doi.org/10.12688/wellcomeopenres.21017.1
A new lineage nomenclature to aid genomic surveillance of dengue virus
Hill V, Cleemput S, Pereira JS, Gifford RJ, Fonseca V, Tegally H, Brito AF, Ribeiro G, de Souza VC, Brcko IC, Ribeiro IS, De Lima ITT, Slavov SN, Sampaio SC, Elias MC, Tran VT, Kien DTH, Huynh T, Yacoub S, Dieng I, Salvato R, Wallau GL, Gregianini TS, Godinho FMS, Vogels CBF, Breban MI, Leguia M, Jagtap S, Roy R, Hapuarachchi C, Mwanyika G, Giovanetti M, Alcantara LCJ, Faria NR, Carrington CVF, Hanley KA, Holmes EC, Dumon W, Lima ARJ, Oliveira T, Grubaugh ND
PLoS Biol
September 16, 2024
DOI: 10.1371/journal.pbio.3002834
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