Typhoid fever, caused by Salmonella enterica serovar Typhi (S.Typhi) is a major cause of febrile illness. Annually, an estimated 12 million infections and over 128,000 deaths are attributed to the disease globally. It is a public health problem in Nepal. In 2022 a new Typhoid Conjugate Vaccine (TCV) was launched in Nepal, after a clinical trial involving 20,000 children aged between the ages of 9 months and 16 indicated it was effective in preventing illness and death. Public Engagement was central to the trial. Find out how.