Prof. Guy Thwaites

Name

Prof Guy Thwaites, MA (Cantab) MBBS MRCP FRCPath PhD.

Positions

Director of the Oxford University Clinical Research Unit and Wellcome Trust Major Overseas Programme in Viet Nam
Professor of Infectious Diseases, University of Oxford
Honorary Consultant in Infectious Diseases and Clinical Microbiology at Guy’s and St. Thomas’ NHS Foundation Trust.

 

About

Guy qualified from Cambridge University and the United Medical and Dental schools of Guy’s and St Thomas’ and trained in Infectious Diseases and Microbiology in Brighton, the Oxford University Clinical Research Unit (OUCRU) in Vietnam, Imperial College London, and the Hospital for Tropical Diseases in London. His research interests focus on the management of severe bacterial infections, especially those involving the central nervous system. He has held Wellcome Trust Training (2001-2004) and Intermediate (2006-2011) Fellowships, and was recently awarded a Wellcome Trust Investigator Award (2016-2023) to further his research on tuberculosis in Vietnam.

In 2013 he was appointed Director of the Oxford University Clinical Research Unit and Wellcome Trust Major Overseas Programme in Viet Nam. He is responsible for the scientific strategy and day-to-day management of the entire programme, which includes research units in Viet Nam, Nepal and Indonesia.

 

Email

gthwaites@oucru.org

 

Webpages

http://www.ndm.ox.ac.uk/principal-investigators/researcher/guy-thwaites

http://www.oucru.org/

Publications

Prof. Thwaites has published more than 160 articles in international journals and has an H index of 41 (Scopus).

 

Key recent research articles:

Chung The H, Rabaa MA, Pham Thanh D, De Lappe N, Cormican M, Valcanis M, Howden BP, Wangchuk S, Bodhidatta L, Mason CJ, Nguyen Thi Nguyen T, Vu Thuy D, Thompson CN, Phu Huong Lan N, Voong Vinh P, Ha Thanh T, Turner P, Sar P, Thwaites GE, Thomson NR, Holt KE, Baker S. South Asia as a Reservoir for the Global Spread of Ciprofloxacin-Resistant Shigella sonnei: A Cross-Sectional Study. PLoS Med. 2016 Aug 2;13(8):e1002055

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Pham Thanh D, Karkey A, Dongol S, Ho Thi N, Thompson CN, Rabaa MA, Arjyal A, Holt KE, Wong V, Tran Vu Thieu N, Voong Vinh P, Ha Thanh T, Pradhan A, Shrestha SK, Gajurel D, Pickard D, Parry CM, Dougan G, Wolbers M, Dolecek C, Thwaites GE, Basnyat B, Baker S. A novel ciprofloxacin-resistant subclade of H58 Salmonella Typhi is associated with fluoroquinolone treatment failure. Elife. 2016 Mar 11;5:e14003

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Heemskerk AD, Bang ND, Mai NT, Chau TT, Phu NH, Loc PP, Chau NV, Hien TT, Dung NH, Lan NT, Lan NH, Lan NN, Phong le T, Vien NN, Hien NQ, Yen NT, Ha DT, Day JN, Caws M, Merson L, Thinh TT, Wolbers M, Thwaites GE, Farrar JJ. Intensified Antituberculosis Therapy in Adults with Tuberculous Meningitis. The New England Journal of Medicine. 2016;374(2):124-34
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Arjyal A, Basnyat B, Nhan HT, Koirala S, Giri A, Joshi N, Shakya M, Pathak KR, Mahat SP, Prajapati SP, Adhikari N, Thapa R, Merson L, Gajurel D, Lamsal K, Lamsal D, Yadav BK, Shah G, Shrestha P, Dongol S, Karkey A, Thompson CN, Thieu NT, Thanh DP, Baker S, Thwaites GE, Wolbers M, Dolecek C. Gatifloxacin versus ceftriaxone for uncomplicated enteric fever in Nepal: an open-label, two-centre, randomised controlled trial. The Lancet Infectious Diseases. 2016.4835582

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Key review articles/books chapters.

Thwaites GE and Day NP. Approach to fever in the returning traveler. NEJM. 2017 Feb 9;376(6):548-560

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Marais BJ, Heemskerk AD, Marais SS, van Crevel R, Rohlwink U, Caws M, Meintjes G, Misra UK, Mai NT, Ruslami R, Seddon JA, Solomons R, Toorn RV, Figaji A, McIlleron H, Aarnoutse R, Schoeman JF, Wilkinson RJ, Thwaites GE; Tuberculous Meningitis International Research Consortium. Standardized Methods for Enhanced Quality and Comparability of Tuberculous Meningitis Studies. Clin Infect Dis. 2017 Feb 15;64(4):501-509.

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Nhung NT, Cuong NV, Thwaites G, Carrique-Mas J. Antimicrobial Usage and Antimicrobial Resistance in Animal Production in Southeast Asia: A Review. Antibiotics (Basel). 2016 Nov 2;5(4). pii: E37.

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Thuong NT, Thwaites GE. Treatment associated inflammatory deterioration in tuberculous meningitis: unpicking the paradox. J Infect Dis. 2016 Dec 8. pii: jiw565.

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Thwaites GE, van Toorn R, Schoeman J. Tuberculous meningitis: more questions, still too few answers. Lancet Neurol. 2013 Oct;12(10):999-1010. doi: 10.1016/S1474-4422(13)70168-6. Epub 2013 Aug 23. PMID: 23972913