Zoonoses

Zoonoses are diseases that are transmitted between animals and humans. Approximately 60-70% of emerging infectious disease pathogens are originated from animals. Zoonotic pathogens can infect humans via direct or indirect exposure to animals, including wild and domesticated animals.

Zoonoses are diseases that are transmitted between animals and humans. Approximately 60-70% of emerging infectious disease pathogens are originated from animals. Zoonotic pathogens can infect humans via direct or indirect exposure to animals, including wild and domesticated animals.

The over usage of antimicrobials in food animal production, which is accounted for two-thirds of global antimicrobial use (AMU), and for human healthcare, which is the driver for antimicrobial resistance (AMR) in microorganisms, could lead to the zoonotic transmission of AMR pathogens. This will impact AMR, the global health threat on the AMR emergence. Vietnam is among the top 5 countries with the greatest projected percentage increases in antimicrobial consumption by 2030.

Current research themes:

Using a multidisciplinary approach, including social science, microbiology, molecular biology and whole genome sequence analysis and One-Health networks in the field of human and animal health, our group aims to understand:

  • The mechanisms of zoonotic transmission of Streptococcus suis, non-typhoidal Salmonella, and Escherichia coli,
  • How the AMU in food animal farm settings could influence the development of AMR in the abovementioned bacteria and their zoonotic transmission to communities.

We also study the driver of AMR bacteria in the community, with a particular focus on E. coli and S. pneumonia.

RESEARCHERS

People Investigating This Issue

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Publications

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The emergence and diversification of a zoonotic pathogen from within the microbiota of intensively farmed pigs
Gemma G R Murray, A S Md Mukarram Hossain, Eric L Miller, Sebastian Bruchmann, Andrew J Balmer, Marta Matuszewska, Josephine Herbert, Nazreen F Hadjirin, Robert Mugabi, Ganwu Li, Maria Laura Ferrando, Isabela Maria Fernandes de Oliveira, Thanh Nguyen, Phung L K Yen, Ho D Phuc, Aung Zaw Moe, Thiri Su Wai, Marcelo Gottschalk, Virginia Aragon, Peter Valentin-Weigand, Peter M H Heegaard, Manouk Vrieling, Min Thein Maw, Hnin Thidar Myint, Ye Tun Win, Ngo Thi Hoa, Stephen D Bentley, Maria J Clavijo, Jerry M Wells, Alexander W Tucker, Lucy A Weinert.
Proc Natl Acad Sci USA
November 21, 2023
DOI: 10.1073/pnas.2307773120
Prevalence and Associated Factors of optrA-Positive- Enterococcus faecalis in Different Reservoirs around Farms in Vietnam
Hoang Thi An Ha, Phuong Thi Lan Nguyen, Tran Thi Mai Hung, Le Anh Tuan, Bui Thanh Thuy, Tran Hoang My Lien, Pham Duy Thai, Nguyen Ha Thanh, Vu Thi Ngoc Bich, Tran Hai Anh, Ngo Thi Hong Hanh, Nguyen Thi Minh, Duy Pham Thanh, Si-Nguyen T Mai, Hao Chung The, Nguyen Vu Trung, Nguyen Hoai Thu, Tran Nhu Duong, Dang Duc Anh, Pham Thi Ngoc, Anne-Laure Banuls, Marc Choisy, H Rogier van Doorn, Masato Suzuki, Tran Huy Hoang
Antibiotics (Basel)
May 24, 2023
DOI: 10.3390/antibiotics12060954
Using unique ORFan genes as strain-specific identifiers for Escherichia coli
Marta Ferrandis-Vila, Sumeet K. Tiwari, Boas van der Putten, Nguyen V. Trung, Rik Oldenkamp, Martin Bootsma, Sebastien Matamoros, Hoa T. Ngo, Julio Alvarez, Jennifer M. Ritchie, Amanda Fivian-Hughes, Angelika Fruth, Joy Leng, Roberto M. La Ragione, Maria Ugarte-Ruiz, Astrid Bethe, Stefan Schwarz, Torsten Semmler, Constance Schultsz, Christian Menge & Christian Berens
BMC Microbiol
May 18, 2022
DOI: 10.1186/s12866-022-02508-y
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Projects
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Streptococcus pneumoniae

Identification Of Potential Virulence Genes-Associated With Streptococcus Suis Infection In Humans Using Whole-Genome Sequencing Data

Streptococcus suis is an important bacterial pathogen in pigs and also an agent of emerging severe diseases in humans. The project aims to construct a virulence gene database for S. suis which could be applied to screen for the prevalence of those potential virulence genes in the genome of S. suis strains and suggest potential virulence genes involved in the pathogenicity in humans.
May 8, 2023
Technician prepares for a viral whole-genome sequencing experiment at the Cancer Genomics Research Laboratory.

Identification Of Potential Virulence Genes-Associated With Streptococcus Suis Infection In Humans Using Whole-Genome Sequencing Data

Streptococcus suis is an important bacterial pathogen in pigs and also an agent of emerging severe diseases in humans. The project aims to construct a virulence gene database for S. suis which could be applied to screen for the prevalence of those potential virulence genes in the genome of S. suis strains and suggest potential virulence genes involved in the pathogenicity in humans.
May 8, 2023
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