This observational prospective cohort study investigates the emergence and transmission of carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-Kp), a growing public health threat combining antibiotic resistance and high virulence. Stool and throat swabs will be collected from hospitalized patients with K. pneumoniae and their close contacts during and after hospitalization. Through statistical, genomic, and spatiotemporal analyses, the study aims to uncover the epidemiological pathways and determinants driving CR-HvKp evolution and spread, particularly in Asian hospital settings with high carbapenem use and suboptimal infection control.